December 25, 2005: The Institute of Microbiology of the Chinese Academy of Sciences established the Tianjin Industrial Biotechnology R&D Base of the Institute of Microbiology.

2007: CAS decided to rename the Tianjin Industrial Biotechnology R&D Base of the Institute of Microbiology as the Tianjin Institute of Industrial Biotechnology Research and Development Center (in preparation).

2008: CAS decided to rename the center as the Tianjin Institute of Industrial Biotechnology, CAS (in preparation), becoming a research institution directly under CAS.

March 11, 2009：The agreement on joint construction of the Tianjin Institute of Industrial Biotechnology, CAS was signed by the Tianjin Municipal Government and CAS.

February 2012: The Office of the State Commission for Public Sector Reform formally approved the establishment of the Tianjin Institute of Industrial Biotechnology, CAS.

November 29, 2012: The Tianjin Institute of Industrial Biotechnology, CAS was formally established.