Research Divisions----Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences

Introduction

National Engineering Laboratory for Industrial Enzymes was jointly established by Institute of Microbiology, Tianjin Institute of Industrial Biotechnology, Shanghai Institutes for Biological Sciences, Jiangnan University, Jilin University, Biotechnology Research Institute CAAS, Tsinghua University and Tianjin University of Science and Technology. The laboratory focuses on the fundamental and applied research on industrial enzymes with a mission of promoting the advances in the technologies for the discovery, production and applications of industrial enzymes, and facilitating the sustainable development of various industries such as chemical, pharmaceutical, textile, paper, food, animal feeds and energy in China. The laboratory has established the technical platforms for the high-throughput discovery and evaluation, protein engineering, production process development and applications of industrial enzymes. The research groups are working closely with companies in various industries to facilitate their development of new products and processes with the aim to realize their transformation to the sustainable industries. The laboratory also offers graduate education and technical training programs to provide talents for these industries.

Research Areas

1. Industrial Protein Science, including: Discovery and Evaluation of Industrial Enzymes, Protein Structure-Function Relationship，Structural Bioinformatics, Rational Design and Evolution of Industrial Enzymes, Process Development for Efficient Enzyme Production, Application Technologies for Industrial Enzymes.

2. Biotransformation and Process Engineering, including: Discovery and Evolution of Biocatalysts, Mechanistic Studies on Biocatalytic Reactions, Chemical Modification and Immobilization of Biocatalysts, Non-Aqueous Bioprocess Engineering, Chemoenzymatic Synthesis of Complex Molecules.

3. Glycoengineering, Including: Biocatalytic Technology for Rare Sugar/Polyol and Its Utilization; Glycating and Strengthening the Function of Bioactive Substances.

Research Groups and Their Research Interest

Group Leader	Research Interest
Yanhe Ma	Understanding and Application of Extremozymes
Yong Tao	Whole-cell Biocatalyst Development; High-throughput, systematic platform of recombinant protein expression
Shuangyan Tang	Protein engineering & Microbial enzyme applications
Fu Gao/Haixia Xiao	Development of New Therapeutic and Prophylactic Vaccines
Reyting Guo	Crystal Structure Analysis, Design and Evolution of Industrial Enzymes
Hui Song	Screening and Evaluation of Industrial Enzymes
Jiangning Song	Structural Bioinformatics and Systems Biology
Yuanxia Sun	Biocatalysis technology of rare sugar/polyol and its utilization; Glycating and strengthening the function of bioactive substance;
Chaoguang Tian	The molecular mechanism of cellulases expression and secretion in filamentous fungi; and developing the fungal system for cellulases production and heterologous protein expression; Identification and characterization of fungal major facilitator superfamily (MFS) transporters; and constructing the fungal cell factory for bio-based chemicals production.
Qinhong Wang	Evolution of Enzymes and Pathway Architecture
Qiaqing Wu	Discovery and Evolution of Biocatalysts
Huaming Wang	Classic mutagenesis and molecular breeding technology development for Aspergillus niger strain improvement; High efficient extracellular protein expression improvement in Aspergillus niger; New enzymes discovery for feed, food and industrial application;
Dawei Zhang	Bacillus expression system
Dunming Zhu	Mechanistic Studies on Biocatalytic Reactions and Their Application in Organic Synthesis
Peijian Zou	Expression, Purification and Structure-Function Relationship of Industrial Enzymes
Guocheng Du	Biosystem and Bioprocess Engineering
Yan Feng	Structure-Function Relationship and Evolution of Enzymes
Zhengqiang Li	Enzymology and Encapsoulation of Enzymes
Min Lin /Wei Lu	Discovery and Exploitation of Microbial Genetic Resources with Novel Functions
Zhanglin Lin	Design and Application of Enzymatic and Cellular Parts Based on Synthetic Biology
Fuping Lu	Industrial Biocatalysis
Sheng Yang /Rongsheng Tao	Recombinant E.coli based enzyme engineering platform

Drector: Ma Yanhe

Deputy Directors: Zhu Dunming, Lin Zhanglin, Feng Yan

Secretary: Bu Dandan

Tel: 022-8486-1996.