Researchers established the pilot process of L-ergothioneine biosynthesis

L-Ergothioneine ( EGT , ERGO ) is a natural chiral amino-acid antioxidant biosynthesized in certain bacteria and fungi .However , we expect EGT production by submerged fermentation of mushrooms would show great advantages over chemical synthesis , natural bio-extraction and solid fermentation .This research was supported by grants from the Key Projects in the Tianjin Science & Technology Pillar Program ( 10ZCKFSY06300 ) and Tianjin Municipal Natural Science Foundation for Youths ( 13JCQNJC10100 ) .

Multi-strategy prediction method for enzyme knockouts was developed to improve the conversion ratio of microbial strains

The conversion ratio from substrates to target products is one of the important objectives for industrial strains and is also a main cost control in the fermentation process .Based on cell metabolic networks , multi-strategy prediction method , named ReacKnock , for enzyme knockouts was developed by the computational biologists from the Laboratory led by Professor SUN Jibin at Tianjin Institute of Industrial Biotechnology .

Measles contributes to rheumatoid arthritis

Growing evidence from epidemiological studies indicates the association between rheumatoid arthritis ( RA ) and measles .Protein-protein interaction network and previous results from pathway analysis of RA and other autoimmune diseases GWAS . They confirmed four pathways including Cytokine-cytokine receptor interaction , Jak-STAT signaling .Interaction network between proteins encoded by RA susceptibility genes ( Image by CHEN Zugen ' s group ).

Reseaechers analyzed the genome sequence of Alicyclobacillys hesperidum Strain URH17-3-68

Alicyclobacillus hesperidum strain URH17-3-68 was initially isolated from hot spring sludge in Tengchong , Yunnan province , China . It is a thermoacidophilic , aerobic , Gram-positive bacterium , and it grows optimally at 50 to 55 ° C and pH 3.5 to.And Glimmer3.0 . Analysis of gene function was carried out by BLAST . Many important industrial enzyme genes were identified , such as alpha-amylase , alpha-glucosidase , protease , and phospholipase D . Based on 16S rRNA and protein similarity .

A novel pectate lyase gene was cloned and characterized

Pectate lyase ( Pel , EC 4.2.2.2 ) is capable of cleaving α - 1 , 4 linkages in pectate polymers by β - elimination mechanism , producing 4 , 5 - unsaturated oligogalacturonates .A Pel gene ( pelN ) was cloned using degenerate PCR and inverse PCR from the chromosomal DNA of Paenibacillus sp . 0602 by the Laboratory of Structural Bioinformatics and Integrative System Biology led by Professor SONG Jiangning at Tianjin Institute of Industrial Biotechnology .

Cell factories were constructed for microbial production of β-carotene

Laboratory of microbial metabolic engineering led by Professor ZHANG Xueli constructed cell factories for microbial production of β-carotene.

Cell factories were constructed for microbial production of isobutanol

Enhanced Oil Recovery by Bioemulsifier and Biosurfactants

Researchers found a novel L-arabinose isomerase from a food-grade microorganism

Prof. SUN Yuanxia's group found a novel L-arabinose isomerase from from a food-grade microorganism, Pediococcus pentosaceus PC-5, to produce D-tagatose, a functional rare sugar.

New advances in prediction of caspase and granzyme cleavage targets