Our team aims to leverage the magic power of synthetic biology and metabolic engineering to customize cell factories to
i) stably supply high-quality protein resources to the rapidly growing global population;
ii) efficiently produce active plant natural products to ensure the health of humans and economic animals.
To achieve this goal, we develop advanced technologies to genetically edit and high-throughput screen strains and identify the genotype-to-phenotype relationship. We decompose and reprogram the complex biological machinery, iteratively generating superior yeast cell factories that efficiently convert renewable feedstock to functional nutritional resources.
Selected publications
Wang G*, Wu X*, Yin Y*. (2022) Synthetic biology-driven customization of functional feed resources. Trends in Biotechnololy. 40 (7): 777-780.
Wang G, Tavares A, Schmitz S, Franca L, Almeida H, Cavalheiro J, Carolas A, Ozmerih S, Blank LM, Ferreira BS*, Borodina I*. (2022) An integrated yeast-based process for cis,cis-muconic acid production. Biotechnology Bioengineering. 119, 376-387
Wang G*, Olofsson-Dolk M, Hansson FG, Donati S, Li X, Chang H, Cheng J, Dahlin J, Borodina I*. (2021) Engineering yeast Yarrowia lipolytica for methanol assimilation. ACS Synthetic Biology. 10, 3537-3550
Wang G*, Kell DB, Borodina I*. (2021) Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites. Essays in Biochemistry. 65, 277-291
Wang G, Hansen IM, Babaei M, D'ambrosio V, Christensen HB, Darbani B, Jensen MK, Borodina I*. (2021) Transportome-wide engineering of Saccharomyces cerevisiae. Metabolic Engineering. 64:52-63
Sáez-Sáez J, Wang G*, Marella ER, Sudarsan S, Pastor MC, Borodina I*. (2020) Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production. Metabolic Engineering, 62:51-61
Wang G, Ozmerih S, Guerreiro R, Meireles AC, Milne N, Jensen MK, Ferreira BS, Borodina I*. (2020) Improvement of cis,cis-muconic acid production in Saccharomyces cerevisiae through biosensor-aided engineering, ACS Synthetic Biology, 9 (3): 634-646
Wang G, Bjork S, Huang M, Liu Q, Campbell K, Nielsen J, Jonsson H*, Petranovic D*. (2019) RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae, Proceedings of the National Academy of Sciences, 116(19), 9324-9332.
Wang G, Jia W, Chen N, Zhang K, Wang L, Lv P, He R, Wang M, Zhang D*. (2018) A GFP-fusion coupling FACS platform for advancing the metabolic engineering of filamentous fungi, Biotechnology for Biofuels; 11:232
Wang G#, Huang M#, Nielsen J*. (2017) Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production, Current Opinion in Biotechnology; 48:77-84
Wang G, Xiong X, Ghogare R, Wang P, Meng Y, Chen S*. (2016) Exploring fatty alcohol-producing capability of Yarrowia lipolytica. Biotechnology for Biofuels; 9:107.
Wang G, Lv P, He R, Wang H, Wang L, Zhang D*, Chen S*. (2015) Protein disulfide isomerase homolog TrPDI2 contributing to cellobiohydrolase production in Trichoderma reesei. Enzyme and Microbial Technology; 77:21-28.
Wang G, Wang H, Xiong X, Chen S, Zhang D*. (2015) Mitochondria thioredoxin's backup role in oxidative stress resistance in Trichoderma reesei. Microbiological Research; 171:32-38.
Wang G, Zhang D, Chen S*. (2014) Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30. World Journal of Microbiology & Biotechnology; 30:2587-2595.
Wang G, Zhang M, Gong J, Guo Q, Feng Y, Wang W*. (2012) Increased gibberellin contents contribute to accelerated growth and development of transgenic tobacco overexpressing a wheat ubiquitin gene. Plant Cell Rep 31 (12):2215-2227.