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  Location: Home >> TIB PI
WANG Guokun
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WANG Guokun, Ph.D. 

Associate Investigator, TIB, Tianjin, China

Tel.: 0086-22-24828740

E-mail: wanggk@tib.cas.cn

  

 

 

Professional Experience

2021.06 – present Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Associate Investigator

2018.06 – 2021.05 Co-supervisor of four PhD students, three Master students and one bachelor student, Technical University of Denmark

2018.03 – 2021.05 Postdoctoral research associate, Technical University of Denmark

2016.01- 2018.01 Postdoctoral research associate, Chalmers University of Technology

Education

2012.09 – 2015.12 Doctor of Science (D. Sc) in Biochemical Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2014.07 – 2015.05 Visiting student at Department of Biological System Engineering, Washington State University

2009.09 – 2012.07 Master of Science (M.S.) in Botany, Shandong Agricultural University

2005.09 – 2009.07 Bachelor of Science (BS) in Biological Science, Shandong Agricultural University

Research Interests

Synthetic biology-driven customization of functional nutritional resources

Our team aims to leverage the magic power of synthetic biology and metabolic engineering to customize cell factories to

i) stably supply high-quality protein resources to the rapidly growing global population;

ii) efficiently produce active plant natural products to ensure the health of human and economic animals.

To achieve this goal, we develop advanced technologies to genome edit and high-throughput screen strains and identify the genotype and phenotype relationship. We decompose and reprogram the complex biological machinery, iteratively generating superior yeast cell factories that efficiently convert renewable feedstock to functional nutritional resources.

Selected publications

Wang G, Tavares A, Schmitz S, Franca L, Almeida H, Cavalheiro J, Carolas A, Ozmerih S, Blank LM, Ferreira BS*, Borodina I*. (2022) An integrated yeast-based process for cis,cis-muconic acid production. Biotechnology Bioengineering. 119, 376-387

Wang G*, Olofsson-Dolk M, Hansson FG, Donati S, Li X, Chang H, Cheng J, Dahlin J, Borodina I*. (2021) Engineering yeast Yarrowia lipolytica for methanol assimilation. ACS Synthetic Biology. 10, 3537-3550

Wang G*, Kell DB, Borodina I*. (2021) Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites. Essays in Biochemistry. 65, 277-291

Wang G, Hansen IM, Babaei M, D'ambrosio V, Christensen HB, Darbani B, Jensen MK, Borodina I*. (2021) Transportome-wide engineering of Saccharomyces cerevisiae. Metabolic Engineering. 64:52-63

Sáez-Sáez J, Wang G*, Marella ER, Sudarsan S, Pastor MC, Borodina I*. (2020) Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production. Metabolic Engineering, 62:51-61

Wang G, Ozmerih S, Guerreiro R, Meireles AC, Milne N, Jensen MK, Ferreira BS, Borodina I*. (2020) Improvement of cis,cis-muconic acid production in Saccharomyces cerevisiae through biosensor-aided engineering, ACS Synthetic Biology, 9 (3): 634-646

Wang G, Bjork S, Huang M, Liu Q, Campbell K, Nielsen J, Jonsson H*, Petranovic D*. (2019) RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae, Proceedings of the National Academy of Sciences, 116(19), 9324-9332.

Wang G, Jia W, Chen N, Zhang K, Wang L, Lv P, He R, Wang M, Zhang D*. (2018) A GFP-fusion coupling FACS platform for advancing the metabolic engineering of filamentous fungi, Biotechnology for Biofuels; 11:232

Wang G#, Huang M#, Nielsen J*. (2017) Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production, Current Opinion in Biotechnology; 48:77-84

Wang G, Xiong X, Ghogare R, Wang P, Meng Y, Chen S*. (2016) Exploring fatty alcohol-producing capability of Yarrowia lipolytica. Biotechnology for Biofuels; 9:107.

Wang G, Lv P, He R, Wang H, Wang L, Zhang D*, Chen S*. (2015) Protein disulfide isomerase homolog TrPDI2 contributing to cellobiohydrolase production in Trichoderma reesei. Enzyme and Microbial Technology; 77:21-28.

Wang G, Wang H, Xiong X, Chen S, Zhang D*. (2015) Mitochondria thioredoxin's backup role in oxidative stress resistance in Trichoderma reesei. Microbiological Research; 171:32-38.

Wang G, Zhang D, Chen S*. (2014) Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30. World Journal of Microbiology & Biotechnology; 30:2587-2595.

Wang G, Zhang M, Gong J, Guo Q, Feng Y, Wang W*. (2012) Increased gibberellin contents contribute to accelerated growth and development of transgenic tobacco overexpressing a wheat ubiquitin gene. Plant Cell Rep 31 (12):2215-2227.

 

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