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  Location: Home >> TIB PI
ZHANG Wuyuan

ZHANG Wuyuan, Ph.D. 

Investigator, TIB, Tianjin, China 






2012.9-2016.7     Ph.D. in Biotechnology, Delft University of Technology, Delft, the Netherlands

2009.9-2012.7     Master in Applied Chemistry, Hainan University, Haikou, China

2005.9-2009.7     Bachelor in Applied Chemistry, Hainan University, Haikou, China

Professional Experience

2020.11-now       Principle Investigator, Full Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

2019.9-2019.10     Principle Investigator, Associate Professor, Xi’an Jiaotong Univeristy, Xi’an, China

2015.10-2019.7     Postdoctoral researcher, Delft University of Technology, Delft, the Netherlands

Research Interests

My group focuses on the research of photobiocatalysis, the research topic covers molecular biology and simulation, enzyme engineering, biocatalysis, organic chemistry, chemocatalysis, chemical engineering and material chemistry. The specific research directions are:

-Research on the discovery and mechanism of photoenzymes

-Design and development of new methods and pathways via photobiocatalysis

-Research on the synthesis of functional molecules via photobiocatalysis

-Valorisatin of bio-resources via biocatalysis

-Design and development of green chemistry technology based on biocatalysis

Publication Records

34. Wuyuan Zhang,* Huanhuan Li, Sabry HH Younes, Patricia Gómez de Santos, Florian Tieves, Gideon Grogan,  Martin Pabst, Miguel Alcalde, Adrian C Whitwood, Frank Hollmann*, Biocatalytic Aromaticity-Breaking Epoxidation of Naphthalene, 2020. Submitted.

33. Avinash Alagumalai*, Omid Mahian*, Frank Hollmann, Wuyuan Zhang*, Environmentally Benign Solid Catalysts for Sustainable Biodiesel Production: A Critical Review, Science of the Total Environment, 2020, DOI:

32. Richen Lin, Chen Deng,* Wuyuan Zhang,* Frank Hollmann , and Jerry D. Murphy* Production of Bio-alkanes from Biomass and CO2, Trends in Biotechnology, 2020, DOI: 10.1016/j.tibtech.2020.12.004

31.曾志刚, 桑贤轲, 袁波, 吴鸣虎*, 张武元* 卤过氧化物酶在绿色卤化反应中的研究进展,有机化学,2020 DOI: 10.6023/cjoc202009007.

30. Nuclear Waste and Biocatalysis: A Sustainable Liaison? Wuyuan Zhang*, Huanhuan Liu, Morten M. C. H. van Schie, Peter-Leon Hagedoorn, Miguel Alcalde, Antonia G. Denkova, Kristina Djanashvili, and Frank Hollmann*, ACS Catalysis 2020, 10, 23, 14195–14200.

29. Bo Yuan, Durga Mahor, Qiang Fei, Ron Wever, Miguel Alcalde, Wuyuan Zhang* and Frank Hollmann*, A Water-Soluble Anthraquinone Photocatalyst Enables Methanol Driven Enzymatic Halogenation and Hydroxylation Reactions. ACS Catalysis, 2020. 10, 8277-8284.

28. Wuyuan Zhang#, Jung-Hoo Lee#, Sabry H. H. Younes, Fabio Tonin, Peter-Leon Hagedoorn, Harald Pichler, Yoonjin Baeg, Jin-Byung Park*, Robert Kourist*, Frank Hollmann*, Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acidsNature Communications. 2020, 11, 2258.

27. Jaeho Yoon, Jinhyun Kim, Florian Tieves, Wuyuan Zhang, Miguel Alcalde, Frank Hollmann, Chan Beum Park. Piezobiocatalysis: Ultrasound-Driven Enzymatic Oxyfunctionalization of CH Bonds. ACS Catalysis. 2020. 10, 9, 5236–5242

26. Yunjian Ma, Yongru Li, Shahid Ali, Peilin Li, Wuyuan Zhang, Marine CR Rauch, Sébastien JP Willot, Doris Ribitsch, Young Hae Choi, Miguel Alcalde, Frank Hollmann, Yonghua Wang. Natural Deep Eutectic Solvents as Performance Additives for Peroxygenase Catalysis. ChemCatChem. 2020. 12, 989-994.

25. Yunjian Ma, Xizhen Zhang, Wuyuan Zhang,  Peilin Li,  Yongru Li,  Frank Hollmann*, Yonghua Wang*, Photoenzymatic Production of Next Generation Biofuels from Natural Triglycerides Combining a Hydrolase and a Photodecarboxylase. ChemPhotoChem. 2020. 4, 39-44.

24. Sebastian Bormann,  Morten M. C. H. van Schie,  Tiago Pedroso De Almeida,  Wuyuan Zhang,  Markus St?ckl,  Roland Ulber,  Frank Hollmann*,  HoltmannH2O2*, Production at Low Overpotentials for Electroenzymatic Halogenation Reactions. ChemSusChem. 2019. 12, 4759-4763.

23. Da Som Choi,Hojin Lee, Florian Tieves, Yang Woo Lee, Eun Jin Son, Wuyuan Zhang, Byungha Shin, Frank Hollmann, and Chan Beum Park* Bias-Free In Situ H2O2 Generation in a Photovoltaic-Photoelectrochemical Tandem Cell for Biocatalytic Oxyfunctionalization. ACS Catalysis. 2019. 9, 10562-10566

22. Morten Van Schie,Wuyuan Zhang; Florian Tieves; Da Som Choi;  Chan Beum Park; Bastien Oliver Burek;  Jonathan Bloh; Isabel WCE Arends;  Caroline Paul; Miguel Alcalde;  Cascading g-C3N4 and Peroxygenases for Selective Oxyfunctionalization Reactions. ACS Catalysis 2019. 9, 7409-7417.

21. Wuyuan Zhang, Ming Ma, Mieke M. E. Huijbers, Georgy A. Filonenko, Evgeny A. Pidko, Morten van Schie, Sabrina de Boer, Bastien O. Burek, Jonathan Z. Bloh, Willem J. H. van Berkel, Wilson A. Smith, and Frank Hollmann* Selective Photoenzymatic Synthesis of Light Hydrocarbon. Journal of the American Chemical Society, 2019. 141(7): 3116.

20. Jie Zhang, Fabio Tonin, Wuyuan Zhang, Peter-Leon Hagedoorn, Lloyd Mallee and Frank Hollmann, ‘Clean’ hydrolase reactions using commercial washing powder, RSC Adv., 2019, 9, 24039–24042.

19. Wuyuan Zhang, Elena Fernandez Fueyo  Frank Hollmann  Laura Leemans Martin  Milja Pesic  Rainer Wardenga  Matthias H?hne  Sandy Schmidt Combining Photo-organo redox- and enzyme catalysis facilitates asymmetric C-H bond functionalization. European Journal of Organic Chemistry 2019, 2019, 80-84.

18. Y. Ma, P. Li, S. J.-P. Willot, W. Zhang, D. Ribitsch, Y.Choi, T. Zhang, R. Verpoort, F.Hollmann, Y. Wang, Natural deep eutectic solvents as multifunctional media for the valorisation of agricultural wastes, ChemSusChem, 2019,

17. Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie, Jen? Gacs, Rokus Renirie, Ron Wever, Francesco G. Mutti, D?rte Rother, Miguel Alcalde, and Frank Hollmann*, Selective aerobic oxidation reactions via combination of photocatalytic water oxidation and enzymatic oxyfunctionalisations, Nature Catalysis, 2018, 1(1): 55.

16. M. Huijbers, W. Zhang, F. Tonin, F. Hollmann, Light-driven enzymatic decarboxylation of fatty acids. Angewandte Chemie International Edition, 2018, 57, 13648.

15. W. Zhang, F. Hollmann, Nonconventional regeneration of redox enzymes - a practical approach for organic synthesis? Chemical Communications, 2018, 54, 7281.

14. Dong J, Pasic M, Younes S, Zhang W, Fernandez-Fueyo E, Hollmann F, Caroline E. Paul, M. Pesic, S. Schmidt, Y. Wang, S. Younes, W. Zhang, Biocatalytic oxidation reactions-a Chemist's perspective, Angewandte Chemie International Edition, 2018. 57, 9238.

13. Wuyuan Zhang,  Bastien O. Burek,  Elena FernándezFueyo,  Miguel Alcalde,  Jonathan Z. Bloh*,  Frank Hollmann*, Selective activation of C-H bonds by cascading photochemistry with biocatalysis. Angewandte Chemie International Edition, 2017, 56(48): 15451. Selected as “HOT PAPER” in Angewandte Chemie.

12. Wuyuan Zhang*,Anna Bariotaki, Ioulia Smonou, Frank Hollmann*Visible-light-driven photooxidation of alcohols using surface-doped graphitic carbon nitride, Green Chemistry, 2017, 19: 2096. Selected by the Editorial Board of Synfacts for its important insights as “Synfact of the month” (09/2017).

11. Wuyuan Zhang,* Jen? Gacs, Isabel W. C. E. Arends, Frank Hollmann*, Selective photooxidation reactions using water soluble anthraquinone photocatalysts, ChemcatChem. 2017, 9, 3821.

10. W. Zhang, et al, Surface PEG grafting density determines magnetic relaxation properties of Gd-loaded porous nanoparticles for MR imaging applications, ACS Applied Materials & Interfaces, 2017, 9, 23458.

9. W. Zhang, et al, Nanoparticles of lanthanide oxysulfate/oxysulfide for improved oxygen storage/release,Dalton Transactions, 2016, 45, 14019.

8. J. Martinelli, A.G. Denkova, A. Arranja, B.E. Terpstra, W. Zhang, K. Djanashvili. Fate of organic functionalities conjugated to theranostic nanoparticles upon their activation, Bioconjugate Chemistry. 2016, 27, 446.

7. X. Cui, M.A. Green, P.J. Blower, D. Zhou, Y. Yan, W. Zhang, K. Djanashvili, D. Mathe, D.S. Veres, K. Szigeti. Al(OH)3 facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles. Chemical Communications 2015, 51, 9332-9335.

6. W. Zhang, et al, Prototropic exchange governs T1 and T2 Relaxivities of a potential MRI contrast agent nanozeolite Gd?LTL with a high pH responsiveness, Journal of Physical Chemistry C, 2015, 119, 5080.

5. F. Mayer, W. Zhang, T. Brichart, O. Tillement, C. S. Bonnet, é. Tóth, J. A. Peters and K. Djanashvili, Nanozeolite-LTL with GdIII deposited in the large and EuIII in the small cavities as a magnetic resonance optical imaging probe. Chemistry – A European Journal, 2014, 20, 3358.

4. W. Zhang, et al, Molecular architecture control in synthesis of spherical ln-containing nanoparticles, RSC advances, 2015, 5, 69861.

3. W. Zhang, et al, Double metal cyanide complexes synthesized by solvent-free grinding method for copolymerization of CO2 and propylene oxide, Journal of Applied Polymer Science, 2012, 123, 977.

2. Y. Cheng, L. Lu, W. Zhang, et al, Reinforced low density alginate-based aerogels: Preparation, hydrophobic modification and characterization, Carbohydrate Polymers, 2012, 88, 1093.

1. W. Zhang, et al, Clean and rapid synthesis of double metal cyanide complexes using mechanochemistry. Green Chemistry, 2011, 13, 2701.


1. W Zhang, F Hollmann, Synthesis of Vinyl Polymers via Enzymatic Oxidative Polymerisation, in Enzymatic Polymerization towards Green Polymer Chemistry, 2019, 343-356.


2. F. Hollmann, W. Zhang, F. Tieves, S. Younes, Synthesis of aromatic epoxide derived compounds, 2018, submitted.

1. L. Lu, W. Zhang, Q. Lin, Y. Cheng, B. Lin, L. Pan, N. Xu and Y. Wang, Preparation of double metal cyanide catalyst via ball milling, CN 201010593592.4.


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