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  Location: Home >> TIB PI
ZHU Zhiguang


ZHU Zhiguang, Ph.D. 

Investigator, TIB, Tianjin, China 

Tel: 86-22-24828797 




2009-2013     Ph.D. Department of Biological Systems Engineering, Virginia Tech, USA

2007-2009     M.S. Department of Biological Systems Engineering, Virginia Tech, USA

2003-2007     B.S. Department of Biotechnology, Huazhong University of Science & Technology, China

Professional Experience  

2016-Present   Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

2013-2016     Chief Technology Officer, Cell-Free Bioinnovations Inc., USA

Research Interests 

We are focusing on the field of biochemical engineering, biocatalysis, and bioelectrocatalytic systems. We use the tools and principles of synthetic biology, bioelectrochemistry, and bionanotechnology to investigate fundamental sciences behind biocatalysis and electron transfer, and construct biofuel cells, bioelectrosynthesis cells, and biosensors for real applications. 

Academic Awards

2013    Virginia Tech Biological Systems Engineering, Outstanding Doctoral Student Award

2012    Chinese Government Award for Outstanding Student Abroad

Selected Publications 

·  Wu RR, Ma CL, Zhu ZG*. 2019. Enzymatic electrosynthesis as an emerging electrochemical synthesis platform. Current Opinion in Electrochemistry (doi: 10.1016/j.coelec.2019.08.004)

·  Ma CL, Wu RR, Huang R, Jiang WX, You C, Zhu LL, Zhu ZG*. 2019. Directed evolution of a 6-phosphogluconate dehydrogenase for operating an enzymatic fuel cell at lowered anodic pHs. Journal of Electroanalytical Chemistry 851:113444-1113451

·  Song HY, Ma CL, Liu P, You C, Lin JP, Zhu ZG*. 2019. A hybrid CO2 electroreduction system mediated by enzyme-cofactor conjugates coupled with Cu nanoparticle-catalyzed cofactor regeneration. Journal of CO2 Utilization 34:568-575

·  Xiao XX1, Xia HQ1, Wu RR1, Bai L, Yan L, Magner E, Cosnier S, Lojou E*, Zhu ZG*, Liu AH*. 2019. Tackling the challenges of enzymatic (bio)fuel cells. Chemical Reviews 119:9509-9558 (1 co-first authors)

·  Wu RR, Ma CL, Yong Y-C, Zhang Y-HP, Zhu ZG*. 2019. Composition and distribution of internal resistance in an enzymatic fuel cell and its dependence on cell design and operating conditions. RSC Advances 9:7292-7300

·  Kang ZP, Zhang Y-HP, Zhu ZG*. 2019. A shriveled rectangular carbon tube with the concave surface for high-performance enzymatic glucose/O2 biofuel cells. Biosensors and Bioelectronics 132:76-83

·  Song HY, Ma CL, Zhou W, You C, Zhang Y-HP, Zhu ZG*. 2018. Construction of enzyme-cofactor/mediator conjugates for enhanced in vitro bioelectricity generation. Bioconjugate Chemistry 29:3993-3998

·  Wu RR, Zhu ZG*2018. Self-Powered Enzymatic Electrosynthesis of L-3,4-Dihydroxyphenylalanine in a Hybrid Bioelectrochemical System. ACS Sustainable Chemistry Engineering 6:12593-12597

·  Zhou W, Huang R, Zhu ZG*, Zhang Y-HP*. 2018. Coevolution of both Thermostability and Activity of Polyphosphate Glucokinase from Thermobifida fusca YX. Applied & Environmental Microbiology 84:e01224-18

·  Meng DD, Wei XL, Zhang Y-HP, Zhu ZG, You C*, Ma YH. 2018. Stoichiometric Conversion of Cellulosic Biomass by in Vitro Synthetic Enzymatic Biosystems for Biomanufacturing. ACS Catalysis 8:9550-9559

·  Wu RR, Ma CL, Zhang Y-HP, Zhu ZG*2018. Complete oxidation of xylose for bioelectricity generation by reconstructing a bacterial xylose utilization pathway in vitro. ChemCatChem 10:2030-2035

·  Zhu ZG*, You C, Ma YH, Zhang Y-HP. 2018. In vitro synthetic enzymatic biosystems at the interface of the food-energy-water nexus: A conceptual framework and recent advances. Process Biochemistry 74:43-49

·  Zhu ZG*, Ma CL, Zhang Y-HP. 2018. Co-utilization of mixed sugars in an enzymatic fuel cell based on an in vitro enzymatic pathway. Electrochimica Acta 263:184-191

·  You C*, Huang R, Wei XL, Zhu ZG, Zhang Y-HP. 2017. Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes, with applications in synthetic biology. Synthetic and Systems Biotechnology2:208-218

·  Zhu ZG, Zhang Y-HP*. 2017. In vitro metabolic engineering of bioelectricity generation by the complete oxidation of glucose. Metabolic Engineering 39:110-116


Before TIB

·  Chen H#, Zhu ZG#, Huang R, Zhang Y-HP. 2016. Coenzyme engineering of a hyperthermophilic 6-phosphogluconate dehydrogenase from NADP+ to NAD+ with its application to biobatteries. Scientific Reports 6:36311 (#co-first author)

·  Zhu ZG, Zhang Y-HP. 2015. Use of nonimmobilized enzymes and mediators achieved high power densities in closed biobatteries. Energy Science & Engineering 3:490-497

·  Zhu ZG, Tam TK, Sun FF, You C, Zhang Y-HP. 2014. A high-energy-density sugar biobattery based on a synthetic enzymatic pathway. Nature Communications 5:3026

·  Zhu ZG, Tam TK, Zhang Y-HP. 2013. Cell-free biosystems in the production of electricity and bioenergy. Advances in Biochemical Engineering/Biotechnology 137:125-152

·  Zhu ZG, Sun FF, Zhang XZ, Zhang Y-HP. 2012. Deep oxidation of glucose in enzymatic fuel cells through a non-natural synthetic enzymatic pathway containing a cascade of two thermostable dehydrogenases. Biosensors and Bioelectronics 36: 110-115

·  Zhu ZG, Wang YR, Minteer SD, Zhang Y-HP. 2011. Maltodextrin-powered enzymatic fuel cell through a non-natural enzymatic pathway. Journal of Power Sources 196:7505-7509

·  Zhu ZG, Sathitsuksanoh N, Vinzant T, Schell DJ, McMillan JD, Zhang Y-HP. 2009. Comparative study of corn stover pretreated by dilute acid and cellulose solvent-based lignocellulose fractionation: Enzymatic hydrolysis, supramolecular structure, and substrate accessibility. Biotechnology and Bioengineering 103: 715-724

·  Zhu ZG, Sathitsuksanoh N, Zhang Y-HP. 2009. Direct quantitative determination of adsorbed cellulase on lignocellulosic biomass with its application to study cellulase desorption for potential recycling. Analyst 134:2267-2272


Zhang Y-H.Percival, Zhu Zhiguang. A high-power and high-energy-density sugar biobattery through an in vitro synthetic enzymatic pathway. U.S. Patent PCT/US14/41103

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