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ZHU Yueming
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ZHU Yueming, Ph.D.  

Associate Investigator, TIB, Tianjin, China  

Tel: 0086-22-84861961  

Fax: 0086-22-84861961

E-mail: zhu_ymATtib.cas.cn 

Education

2004-2009   Ph.D. Microbiology, College of Life Sciences, Nankai University, China

2000-2004   B.S. Biotechnology, College of Life Sciences, Nankai University, China 

Professional Experience

2014-Present   Associate professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

2009-2014       Assistant professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

Research Interest

Research interest focus on the conversion of functional rare sugar using novel enzymes. The main research directions include:

(1) Screening and identification of novel microbial and enzymes for rare sugars conversion

(2) Structure analysis and directed evolution of enzymes

(3) Construction and optimization of engineering strains for producing enzymes or rare sugars

(4) Exploration the conversion processes of rare sugars

(5) Biotransformation of deoxy rare sugars

Academic Awards

2011   Science and Technology Progress Award  " The key technology of preparation of novel food seasonings composite using biocatalytic method"

2012  Visiting scholar, Kagawa University, Japan

Research Projects

Project Name

Project Source

Execution Time

Construction of lactic acid bacteria cell model to increase the conversion efficient of D-tagatose by the differential selectivity of the cell membrane

National Natural Science Foundation of China

2012.1-2014.12

Research on the key technology for efficient utilization of sugar resources

863 Project

2013.1-2017.12

Key technology for screening and optimization of enzymes for rare sugar conversion

Key Programs of the Chinese Academy of Sciences

2013.1-2015.12

Technology for monosaccharides conversion and preparation of rare sugars

863 Project

2012.1-2015.12

Study on construction of multi-enzyme coupling cell model for rare sugar conversion and whole cell transformation method

National Natural Science Foundation of China

2014.1-2014.12

Biological preparation technology of recombinant collagen and its active peptides

Tianjin Municipal Science and technology innovation fund

2013.4-2016.9

Biological conversion of functional rare sugars

Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences

2010.1-2013.12

Selected Publications

[1] ZHU Yueming, Wei Dongsheng, ZHANG Jun, WANG Yufan, XU Hengyi, XING Laijun, LI Mingchun. Overexpression and characterization of a thermostable trehalose synthase from Meiothermus ruber[J]. Extremophiles, 2010, 14(1):1-8.

[2] LI Yanjun, ZHU Yueming, LIU Anjun, SUN Yuanxia. Identification and characterization of a novel L-arabinose isomerase from Anoxybacillus flavithermus useful in D-tagatose production[J]. Extremophiles, 2011, 15(3):441-450.

[3] CHAN Hsiu-Chien, ZHU Yueming, HU Yumei, KO Tzu-Ping, HUANG Chun-Hsiang, REN Feifei, CHEN Chun-Chi, MA Yanhe, GUO Rey-Ting, SUN Yuanxia. Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars[J]. Protein Cell, 2012, 3(2):123-131.

[4] ZHU Yueming, MEN Yan, BAI Wei, LI Xiaobo, ZHANG Lili, SUN Yuanxia, MA Yanhe. Overexpression of D-psicose 3-epimerase from Ruminococcus sp. in Escherichia coli and its potential application in D-psicose production[J]. Biotechnol Lett, 2012, 34(10):1901-1906.

[5] LI Xiaobo, ZHU Yueming, ZENG Yan, ZHANG Tongcun, SUN Yuanxia. Overexpression of D-psicose 3-epimerase from Clostridium cellulolyticum H10 in Bacillus subtilis and its Prospect for D-psicose Production[J]. Advance Journal of Food Science and Technology, 2013, 5(3): 264-269.

[6] HAN Wenjia, ZHU Yueming, MEN Yan, YANG Jiangang, LIU Can, SUN Yuanxia. Production of allitol from D-psicose by a novel isolated strain of Klebsiella oxytoca G4A4[J]. J Basic Microbiol, 2014, [Epub ahead of print].

[7] MEN Yan, ZHU Yueming, ZHANG Lili, KANG Zhenkui, IZUMORI Ken, SUN Yuanxia, MA Yanhe. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5[J]. Microbiol Res, 2014, 169(2-3):171-178.

[8] BAI Wei, ZHU Yueming, MEN Yan, LI Xiaobo, IZUMORI Ken, SUN Yuanxia. Bioconversion of D-fructose to D-allose by novel isomerases[J]. Chin J Biotech, 2012, 28(4): 457−465.

[9] MEN Yan, ZHU Yueming, GUAN Yuping, ZHANG Tongcun, IZUMORI Ken, SUN Yuanxia. Screening of food-grade microorganisms for biotransformation of D-tagatose and cloning and expression of L-arabinose isomerase[J]. Chin J Biotech, 2012, 28(5): 592−601.

[10] LI Xiaobo, ZHU Yueming, BAI Wei, ZHANG Tongcun, IZUMORI Ken, SUN Yuanxia. Immobilization of D-psicose 3-epimerase on chitosan for D-psicose conversion[J]. Science and Technology of Food Industry,  2012, 17(34).

[11] ZHANG Lili, ZHU Yueming, MEN Yan, KANG Zhenkui, SUN Yuanxia. Substrate-binding site analysis of the D-psicose 3-epimerase from Ruminococcus sp [J]. Microbiology, 2013-10-12.

[12] HAN Wenjia, ZHU Yueming, BAI Wei, IZUMORI Ken, ZHANG Tongcun, SUN Yuanxia. Production of sugar syrup containing rare sugar using dual-enzyme coupled reaction system[J]. Chin J Biotech, 2014, 30(1): 90–97.

Patents

[1] SUN Yuanxia, ZHU Yueming. The nucleotide sequence of D- tagatose 3- epimerase from Clostridium sp. and its application: China, 201010264400.5[P]. 2010-8-27

[2] SUN Yuanxia, ZHU Yueming. The nucleotide sequence of L-arabinose isomerase from Pediococcus pentosaceus and its application: China, 201110162714.9[P]. 2011-6-17

[3] SUN Yuanxia, ZHU Yueming. The nucleotide sequence of D- tagatose 3- epimerase from Ruminococcus sp. and its application: China, 201110378798.X[P]. 2011-11-25

[4] SUN Yuanxia, ZHU Yueming, HAN Wenjia, YANG Jiangang, MA Yanhe. A strain of Klebsiella oxytoca and its application in the production of allitol: China, 201310354386.1[P]. 2013-8-14

[5] ZHU Yueming, SUN Yuanxia, LI Hongyi, HAN Wenjia, MA Yanhe. The nucleotide sequence of ribitol dehydrogenase from Klebsiella oxytoca and its application: China, 2013103354387.6[P]. 2013-8-14

[6] SUN Yuanxia, YANG Jiangang, ZHU Yueming, LI Jitao, MA Yanhe. A strain of Corynebacterium glutamicum engineering strain, the construction method and its application in the biosynthesis of rare sugars: China, 201410055300.X[P]. 2014-2-19

[7] ZHU Yueming, LI Hongyi, ZENG Yan, MEN Yan, SUN Yuanxia. A strain of Escherichia coli engineering strain, the construction method and its application in the productionof allitol: China, 201410186502.8[P]. 2014-5-6

 

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