XU Zhenghong----Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences

XU Zhenghong, Ph.D.

Investigator, TIB, Tianjin, China

E-mail: xu_zh(AT)tib.cas.cn

Education

2001.3-2005.4 Ph.D. School of Biothnology, Jiangnan University, China

1993.9-1996.6 M.S. School of Life Science, Shangdong University, China

1989.9-1993.6 B.S. Department of Fermentation engineering, Wuxi Institute of light industry, China

Professional Experience

2013- Present, Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

2012.11- Present, Professor, School of Pharmaceutical Science, Jiangnan University, Wuxi, China

2007.6-2012.10, Professor, School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, China

2001.3-2007.6, Lecturer, Associate Professor, Professor, School of Biotechnology, Jiangnan University, Wuxi, China

1996.7-2001.2, Teaching assistant, Lecturer School of Biotechnology, Wuxi University of Light Industry, Wuxi, China

1999.10-2000.9, Visiting scholar, Osaka University, Japan

Research Interest

1. Microbial metabolic engineering and biocatalysis engineering

2. Research and utilization of edible and medicinal fungi

3. Functional analysis and optimization of microbial community in the traditional fermented food processing by utilizing modern biological technology

Research Projects

2011-2015, The bioconversion technology of steroidal compounds, the National High-Tech R&D Program（863） (No. 2011AA02A211)

2013-2016, Construction of Flavour-forming Pathway During Zhenjiang Venigar Fermentation Process Based on Metagenomic Analysis，National Natural Science Foundation of China (No. 31271922)

2011-2013, Functional profiling and Optimization of Microbial Communities of National Cellars Fermentation Process Based on Metagenomic Analysis, National Engineering Research Center of Solid-State Brewing (No. 2011B2211)

2012-2013, Metabolic Engineering of L-serine producing bacteria and Study on its pilot fermentation, Research Project of the Ministry of Education supported by Guangdong Province（2012B091000083）

2013-2016, R&D and industrialization demonstration of low value of shellfish resources processed into high value health food, Scientific research project of public welfare murine industry supported by State Oceanic Administration People’s Republic of China (201305007)

Other university-business cooperation projects, mainly in biocatalysis products, edible and medicinial mushrooms, and probiotics etc.

Selected Publications

1. GENG Yan, HE Zhe, LU Zhen-Ming, XU Hong-Yu, XU Guo-Hua, SHI Jin-Song, XU Zhenghong*. Antrodia camphorata ATCC 200183 sporulates asexually in submerged culture[J]. Appl Microbiol Biotechnol, 2013, 97:2851– 2858.

2. GENG Yan, LU Zhen-Ming, HUANG Wei, XU Hong-Yu, SHI Jin-Song, XU Zhenghong*. Bioassay-Guided Isolation of DPP-4 Inhibitory Fractions from Extracts of Submerged Cultured of Inonotus obliquus[J]. Molecules, 2013, 18:1150-1161.

3. GONG Jin-Song, LI Heng, ZHU Xiao-Yan, LU Zhen-Ming, WU Yan, SHI Jing-Song, XU Zhenghong*. Fungal His-tagged nitrilase from Gibberella intermedia: Gene cloning, heterologous expression and biochemical properties[J]. PLoS ONE, 2012, 7(11): e50622.

4. YU Yong-Jian, LU Zhen-Ming, YU Ning-Hua, XU Wei, LI Guo-Quan, SHI Jing-Song, XU Zhenghong*. HS-SPME/GC-MS and chemometrics for volatile composition of Chinese traditional aromatic vinegar in the Zhenjiang region[J]. J. Inst. Brew., 2012, 118(1): 133–141.

5. GONG Jin-Song, LU Zhen-Ming, LI Heng, SHI Jin-Song, ZHOU Zhe-Min, XU Zhenghong*. Nitrilases in nitrile biocatalysis: Recent progress and forthcoming research[J]. Microbial Cell Factories, 2012, 11:142.

6. XU Meijuan, RAO Zhiming*, DOU Wenfang, YANG Juan, JIN Jian, XU Zhenghong*. Site-directed mutagenesis and feedback-resistant N-acetyl-L-glutamate kinase (NAGK) increase Corynebacterium crenatum L-arginine production[J]. Amino Acids, 2012, 43(1): 255-266.

7. XU Meijuan, Rao Zhiming*, YANG Juan, XIA Haifeng, Dou Wenfang, JIN Jian, XU Zhenghong*. Heterologous and homologous expression of the arginine biosynthetic argC similar to H cluster from Corynebacterium crenatum for improvement of l-arginine production[J]. Journal of Industrial Microbiology & Biotechnology, 2012, 39(3): 495-502.

8. XU Meijuan, Rao Zhiming*, Dou Wenfang, JIN Jian, XU Zhenghong*. Site-Directed Mutagenesis Studies on the l-Arginine-Binding Sites of Feedback Inhibition in N-Acetyl-l-glutamate Kinase (NAGK) from Corynebacterium glutamicum[J]. Current Microbiology, 2012, 64(2): 164-172.

9. LU Zhen-Ming, TAO Wen-Yi*, XU Hong-Yu, LIM Joanne, ZHANG Xiao-Mei, WANG Li-Ping, CHEN Jing-Hua, XU Zhenghong*. Analysis of volatile compounds of Antrodia camphorata in submerged culture using headspace solid-phase microextraction[J]. Food Chemistry, 2011, 127(2): 662-668.

10. LU Zhen-Ming, LEI Jian-Yong, XU Hong-Yu, SHI Jing-Song, Xu Zhenghong*. Optimization of fermentation medium for triterpenoid production from Antrodia camphorata ATCC 200183 using artificial intelligence-based techniques[J]. Applied Microbiology and Biotechnology, 2011, 92(2): 371-379.

11. GONG Jin-Song, LU Zhen-Ming, SHI Jin-Song, DOU Wen-Fang, XU Hong-Yu, ZHOU Zhe-Min, XU Zhenghong*. Isolation, Identification, and Culture Optimization of a Novel Glycinonitrile-Hydrolyzing Fungus—Fusarium oxysporum H3[J]. Appl Biochem Biotechnol, 2011, 165(3-4): 963-977.

12. DOU Wen-Fang, XU Meijuan, CAI Dongmei, ZHANG Xiaomei, RAO Zhiming, XU Zhenghong*. Improvement of l-Arginine Production by Overexpression of a Bifunctional Ornithine Acetyltransferase in Corynebacterium crenatum[J]. Applied Biochemistry and Biotechnology, 2011,165(3-4): 845-855.

13. XU Meijuan, Rao Zhiming*, XU Hong, LAN Chunyan, DOU Wen-Fang, ZHANG Xiaomei, XU Hongyu, Jian JIN, XU Zhenghong*. Enhanced Production of l-Arginine by Expression of Vitreoscilla Hemoglobin Using a Novel Expression System in Corynebacterium crenatum[J]. Applied Biochemistry and Biotechnology, 2011, 163(6):707-719.

14. LU Zhen-Ming, XU Zhenghong*. Antcin A Contributs to anti-inflammatory effect of Niuchangchih (Antrodia camphorate) [J]. Acta Pharmacologica Sinica, 2011, 32(8):981-982.

15. XU Wei, HUANG Zhiyong, ZHANG Xiaojun, LI Qi, LU Zhen-Ming, SHI Jin-Song, XU Zhenghong*, MA Yanhe. Monitoring The Microbial Community During Solid-State Acetic Acid Fermentation Of Zhenjiang Aromatic Vinegar[J]. Food Microbiology, 2011, 28(6): 1175-1181.

16. XU Wei, XU Qingping, CHEN Jinghua, LU Zhen-Ming, XIA Rong, LI Guo-Quan, XU ZhengHong*, MA YanHe. Ligustrazine formation in Zhenjiang aromatic vinegar: changes during fermentation and storing process[J]. Journal of the Science of Food and Agriculture, 2011, 91(9): 1612–1617.

17. LU Zhen-Ming, XU Wei, YU Ning-Hua, ZHOU Tu, LI Guo-Quan, SHI Jin-Song, XU Zhenghong*. Recovery of aroma compounds from Zhenjiang aromatic vinegar by supercritical fluid extraction[J]. International Journal of Food Science and Technology, 2011, 46(7): 1508-1514.

18. LIU Yongfeng, ZHANG Shuling, YONG Yangchun, JI Zhixia, MA Xin, XU Zhenghong*, Shouwen CHEN*, Efficient production of acetoin by the newly isolated Bacillus licheniformis strain MEL09[J]. Process Biochemistry, 2011, 46:390-394.

19. LU Zhen-Ming, TAO Wen-Yi, XU Hong-Yu, AO Zong-Hua, ZHANG Xiao-Mei, XU Zhenghong*. Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats[J]. Natural Product Research, 2011, 25(7): 684-695.

20. XU Hong-Yu, KONG Xiao-Ming, AO Zong-Hua, LU Zhen-Ming, XU Zhenghong*. Inhibitory effect of dry matter of culture broth of Antrodia camphorata in submerged culture on mice Hepatoma 22[J]. Natural Product Research, 2010, 22: 411-415.

21. XU Xin, PANG Chong, YANG Chengjian, ZHENG Yitong, XU Hongyu, LU Zhenming, XU Zhenghong*. Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice[J]. International Journal of Medicinal Mushoom, 2010, 12: 235-244.