Vice President and Investigator, TIB, Tianjin, China
1989-1993Shandong University, Department of Microbiology, Jinan, China, Bachelor
1993-1996Shandong University, Department of Microbiology, Jinan, China, Master
2001-2004German Research Center for Biotechnology (GBF), Braunschweig, Germany, Biotechnology, PhD
2004-2008Helmoholz Center for Infection Research (former GBF), Braunschweig, Germany, Lab of Systems Biotechnology, Post-doctoral
1996-2000 National Key Lab of Microbial Technology, Shandong University, Jinan, China, Lecturer
Since 2008Tianjin Institute of Industrial Biotechnology, Chinese Academy ofSciences (TIB/CAS), Tianjin, China, Professor
Since 2011Deputy Director of the Key Laboratory of Systems Microbial Biotechnology, CAS
Since 2012 Deputy Director of TIB/CAS
Excellent doctoral thesis award of GBF foundation, Germany (2005)
We focus on systems biology of industrial microorganisms. The diverse microorganisms from industrial practices are invaluable to understand the biological basis for efficient industrial processes and essential for designing next-generation cell factories for the coming era of bioindustry. We are devoted to developing and improving systems and synthetic biology toolboxes to understand the hyper-production mechanisms and metabolic and regulatory bottlenecks of industrial strains, to reconfiguring the industrial bugs or creating new cell factories by computational design and genome-scale metabolic engineering to gain better production performance for amino acid, organic acid and related chemicals.
Fig: Research focus, positioning and strategy
1.Zixiang Xu, Xiao Sun, Jibin Sun. Construction and Analysis of the Model of EnergyMetabolism in E. coli. PLOS ONE2013,8(1):e55137
2.Feng Geng , Zhen Chen, Ping Zheng , Jibin Sun ,An-Ping Zeng. Exploring the allosteric mechanism of dihydrodipicolinatesynthase by reverse engineering of the allosteric inhibitorbinding sites and its application for lysine production. Appl Microbiol Biotechnol 2013, 97:1963-1971.
3.Yan Zhu, Jiangning Song, Zixiang Xu, Jibin Sun,Yanping Zhang,Yin Li,Yanhe Ma. Development of Thermodynamic OptimumSearching (TOS) to Improve the PredictionAccuracy of Flux Balance Analysis. Biotechnol Bioeng 2013,110(3):914-923
4.Lilu Zhang, Jiuzhou Chen, Ning Chen1, Jibin Sun, Ping Zheng, Yanhe Ma. Cloning of two 5-Aminolevulinic Acid Synthase Isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characters for 5-aminolevulinic acid production. Biotechnology Letters 2013, 35:763–768.
5.Lin Chen, Zhen Chen, Ping Zheng, Jibin Sun, An-Ping Zeng. Study and reengineering of the binding sites and allostericregulation of biosynthetic threonine deaminase by isoleucineand valine in Escherichia coli. Appl Microbiol Biotechnol 2013, 97:2939-49.
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