TU Ran, Ph.D.
Associate Investigator, TIB, Tianjin, China
Tel: 0086-22-24828705
Fax: 0086-22-84861950
Email: tu_r(AT)tib.cas.cn
Education
09/1996-06/2000 B.S. of Engineering, South China University of Technology (SCUT), China
Project: Asymmetric synthesis of mandelonitrile by (R)-Oxynitrilase catalysis in non-aqueous phase
10/2000-04/2001 Guest research, Department of Biology, Peking University (PKU), China
Lab of Protein Engineering
Project: Purification of human proinsulin and its mutants to study the function of disulfide bond in insulin
09/2001-06/2006 Ph.D. of Microbiology, Department of Microbiology, China Agricultural University (CAU), China
Lab of Regulation of Biological Nitrogen Fixation
Project: Mechanism of nitrogen fixation regulatory protein NifA in Azospirillum brasilense Sp7
08/2006-03/2007 Postdoctoral Research, Department of Chemical Engineering, Tsinghua University (THU), China
Lab of Plant cell culture
Project: Biosynthesis mechanism of crocin in Crocus sativus L
04/2007-08/2010 Ph.D. fellow, School of Engineering and Science, Jacobs University Bremen (JUB), Germany
In Prof. Schwaneberg’s group
Project: Flow cytometry based high throughput screening system for screening and improving industrially important enzymes
Professional Experience
Since 09/2010 Associate research (co-PI), Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (TIB, CAS)
Research Interest
Since 2010, Dr. Ran Tu has joined in Prof. Wang’s group, worked as an associate professor in Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. She has research experience on asymmetric synthesis, microbial fermentation, protein engineering, and metabolic regulation. Her current research interest focuses on development of ultra-high throughput screening systems for screening and improving industrially important enzymes.
Selected Publications
1. Sun L, Zhang H, Yuan H, Tu R*, Wang Q, Ma Y. A double-enzyme-coupled assay for high-throughput screening of succinic acid-producing strains. J Appl Microbiol. 2013 114:1696-1701.
2. Martinez R, Jakob F, Tu R, Siegert P, Maurer KH, Schwaneberg U. Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution. Biotechnol Bioeng. 2013 110:711-720.
3. Tu R, Martinez R, Prodanovic R, Klein M, Schwaneberg U. A flow cytometry-based screening system for directed evolution of proteases. Journal of Biomolecular Screening. 2011 16:285-294.
4. Qi X, Zhang Y, Tu R, Lin Y, Li X, Wang Q. High-throughput screening and characterization of xylose-utilizing, ethanol-tolerant thermophilic bacteria for bioethanol production. Journal of Applied Microbiology. 2011 110:1584-1591.
5. Cui Y, Tu R, Wu L, Hong Y, Chen S. A hybrid two-component system protein from Azospirillum brasilense Sp7 was involved in chemotaxis. Microbiology Research. 2011 166:458-467.
6. Tu R, Prodanovic R, Blanusa M, Ostafe R, Niehaus F, Eck J, Schwaneberg U. Flow cytometry based high throughput screening system for screening and improving industrially important enzymes. New Biotechnology. 2009 25:S144.
7. Tu R, Cui YH, Chen SF, Li JL. PAS domain of the deduced Org35 protein mediates the interaction with NifA. Chinese Science Bulletin. 2006 51:1141-1144.
8. Cui Y, Tu R, Guan Y, Ma L, Chen S. Cloning, sequencing, and characterization of the Azospirillum brasilense fhuE gene. Current Microbiology. 2006 52:169-177.
