President's mail  |   Contact  |   CAS  |   中文  |   Sitemap     
  Location: Home >> TIB PI
Liu Tao

LIU Tao, Ph.D.

Investigator, TIB, Tianjin, China

Tel: 022-24828718

Fax: 022-84861996



1992-1996    Shandong Normal University, B.Sc, in Biological Science

1996-1999    Shandong Normal University, M.S., in Botany

2001-2002    East Tennessee State University ,  Graduate Student in Biological Science

2002-2006    University of Kentucky, Ph.D in Pharmaceutical Science

2006-2009    Postdoctoral Research Associate, University of Wisconsin, Madison

Professional Experience

1999-2001    Research Associate, Shandong Agricultural Industry and Commerce Group Corp

2009-2010    Manager/Staff Scientist, SelectX Pharmaceuticals Inc

2011-            Professor, Institute of Industrial Biotechnology, Chinese Academy of Sciences

Research Interest

The research of our group is focused on natural product biosynthesis. It includes: the elucidation of complex multi-step biosynthetic pathways, carried out by plants or bacteria, with particular emphasis on enzyme mechanisms; efficient production of highly valuable chemicals in simple micro-organism by metabolic engineering; generation of unnatural natural products through combinatorial biosynthesis; discovery and identification of  novel bioactive natural products.

Selected Publications

1.        Huiping Bi, Yanfen Bai, Tao Cai, Yibin Zhuang, Xiaomei Liang, Xueli Zhang, Tao Liu*, Yanhe Ma. (2013) Engineered short branched-chain acyl-CoA synthesis in E. coli and acylation of chloramphenicol to branched-chain derivatives.  Appl. Microbiol. Biotechnol.  DOI 10.1007/s00253-013-5262-6

2.        Micah. D. Shepherd, Tao Liu, Carmen Méndez, Jose A Salas, Jurgen Rohr*. (2011) Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties. Appl. Environ. Microbiol. 77(2):435-41.

3.        Tao Liu, Yong Huang and Ben Shen* (2009) Bifunctional acyltransferase/decarboxylase LnmK as the missing link for β-alkylation in polyketide biosynthesis. J. Am. Chem. Soc. 131(20), 6900-6901.

4.        Tao Liu, Madan K. Kharel, Lili Zhu, Samuel A. Bright, Cynthia Mattingly, Val R. Adams, and Jürgen Rohr (2009) Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity. Chembiochem, 10 (2): 278-286.

5.        Madan K. Kharel, Lili Zhu, Tao Liu, and Jürgen Rohr (2007) Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses. J. Am. Chem. Soc. 129(13):3780-1.

6.        Tao Liu, Madan Kharel, Carsten Fischer, Andrew McCormick, and Jürgen Rohr (2006). Inactivation of gilGT encoding a C-Glycosyltransferse and gilOIII encoding a P450-enzyme, allows to delineate details of the biosynthetic pathway of gilvocarcin V. Chembiochem. 7:1070-1077.

7.        Tao Liu, Carsten Fischer, Claus Beninga, and Jürgen Rohr (2004). Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.  J. Am. Chem. Soc. 126(39):12262-3.


32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China
Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh(AT)
Copyright @2013, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences