2011- Professor, Institute of Industrial Biotechnology, Chinese Academy of Sciences
The research of our group is focused on natural product biosynthesis. It includes: the elucidation of complex multi-step biosynthetic pathways, carried out by plants or bacteria, with particular emphasis on enzyme mechanisms; efficient production of highly valuable chemicals in simple micro-organism by metabolic engineering; generation of unnatural natural products through combinatorial biosynthesis; discovery and identification ofnovel bioactive natural products.
3.Tao Liu, Yong Huang and Ben Shen* (2009) Bifunctional acyltransferase/decarboxylase LnmK as the missing link for β-alkylation in polyketide biosynthesis. J. Am. Chem. Soc. 131(20), 6900-6901.
4.Tao Liu, Madan K. Kharel, Lili Zhu, Samuel A. Bright, Cynthia Mattingly, Val R. Adams,and Jürgen Rohr (2009) Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity. Chembiochem, 10 (2): 278-286.
5.Madan K. Kharel, Lili Zhu, Tao Liu, and Jürgen Rohr (2007) Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses. J. Am. Chem. Soc. 129(13):3780-1.
6.Tao Liu, Madan Kharel, Carsten Fischer, Andrew McCormick, and Jürgen Rohr (2006). Inactivation of gilGT encoding a C-Glycosyltransferse and gilOIII encoding a P450-enzyme, allows to delineate details of the biosynthetic pathway of gilvocarcin V. Chembiochem. 7:1070-1077.
7.Tao Liu, Carsten Fischer, Claus Beninga, and Jürgen Rohr (2004). Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.J. Am. Chem. Soc. 126(39):12262-3.
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