TIAN Chaoguang----Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences

TIAN Chaoguang, Ph.D.

Investigator, TIB, Tianjin, China

Tel: 0086-22- 84861947

Fax: 0086-22- 84861948

E-mail: tian_cg@tib.cas.cn

Education

2005 PhD, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

2005-2009 Postdoc, University of California at Berkeley

Professional Experience

2010- PI, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Research Interest

The primary focus of the lab is fungal biotechnology for industrial enzymes and biobased chemicals production. Current projects in our lab makes use of synthetic biology, functional genomics, genetics and metabolic engineering to address fundamental issues in this field:

1) the mechanism of the protein secretion in filamentous fungi, and developing the fungal system for industrial enzymes production and the heterologous protein expression;

2)the mechanism of biorefinery, and constructing the fungal cell factory for biobased chemicals production .

Selected Publications

1. Li J, Lin L, Sun T, Xu J, Ji J, Liu Q, Tian C*. Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila. Metabolic Engineering, 2019, 10.1016/j.ymben.2019.05.007

2. Liu Q, Li J, Gao R, Li J, Ma G, Tian C*. CLR-4, a novel conserved transcription factor for cellulase gene expression in ascomycete fungi. Mol Microbiol, 2019, 111: 2, 373-394

3. Gu S, Li J, Chen B, Sun T, Liu Q, Xiao D, Tian C*. Metabolic engineering of the thermophilic lamentous fungus Myceliophthora thermophila to produce fumaric acid. Biotechnol Biofuels, 2018, 11: 323

4. Lin L, Sun Z, Li J, Chen Y, Liu Q, Sun W, Tian C*. Disruption of gul-1 decreased the culture viscosity and improved protein secretion in the filamentous fungus Neurospora crassa. Microb Cell Fact, 2018, 17 (1): 96

5. Xu G, Li J, Liu Q, Sun W, Jiang M, Tian C*. Transcriptional analysis of Myceliophthora thermophila on soluble starch and role of regulator AmyR on polysaccharide degradation. Bioresour Technol, 2018, 265: 558-562

6. Wang B, Li J, Gao J, Cai P, Han X, Tian C*. Identification and Characterization of the Glucose Dual-Affinity Transport System in Neurospora crassa: Pleiotropic Roles in Nutrient Transport, Signaling, and Carbon Catabolite Repression. Biotechnol Biofuels, 2017, 10: 17

7. Liu Q, Gao R, Li J, Lin L, Zhao J, Sun W, Tian C*. Development of a genome-editing CRISPR/Cas9 system in thermophilic fungal Myceliophthora species and its application to hyper-cellulase production strain engineering. Biotechnol Biofuels, 2017, 10: 1

8. Fan F, Ma G, Li J, Liu Q, Benz JP, Tian C*, Ma Y. Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa. Biotechnol Biofuels. 2015, 8: 66

9. Li J, Xu J, Cai P, Wang B, Ma Y, Benz JP*, Tian C*. The functional analysis of two related L-arabinose transporters from filamentous fungi reveals promising characteristics for improved pentose utilization in yeast. Appl Environ Microbiol, 2015, 81 (12): 4062- 4070

10. Wang B, Cai P, Sun W, Li J, Tian C*, Ma Y. A transcriptomic analysis of Neurospora crassa using five major crop residues and the novel role of the sporulation regulator rca- 1 in lignocellulase production. Biotechnol Biofuels, 2015, 8: 21

11. 10. Xu J, Li J, Lin L, Liu Q, Sun W, Huang B, Tian C*. Development of genetic tools for Myceliophthora thermophila. BMC Biotechnol, 2015, 15: 35

12. Pei X, Fan F, Lin L, Chen Y, Sun W, Zhang S*, Tian C*. Involvement of the adaptor protein 3 complex in lignocellulase secretion in Neurospora crassa revealed by comparative genomic screening. Biotechnol Biofuels, 2015, 8: 124

13. Cai P, Wang B, Ji J, Jiang Y, Wan L, Tian C*, Ma Y. The Putative Cellodextrin Transporter-like Protein CLP1 Is Involved in Cellulase Induction in Neurospora crassa. J Biol Chem, 2015, 290: 788-796