SONG Hui, Ph.D.
Investigator, TIB, Tianjin, China
Tel: 022-84861934
Fax: 022-84861933
E-mail: song_h(AT)tib.cas.cn
Education
1979-1983 B.Sc. in Microbiology, NankaiUniversity, PR China
1995-1997 M.Sc. in Molecular Biology, Vrije Universiteit Brussel, Belgium
1997-2000 Ph.D. in Molecular Biology, Vrije Universiteit Brussel, Belgium
Professional Experience
2001-2004 Postdoctoral Research Associate, Drexel University, University of Notre Dame. Indiana University Purdue University at Indianapolis, USA
2004-2006 Research Associate, University of Toronto St. Michael Hospital, Canada
2006-2007 Research Scientist, Indiana University Purdue University at Indianapolis, USA
2007- Professor (Principal Investigator),Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences.
Research Interest
According to the status of Industrial enzyme preparations and market demand in our country, we mainly focus on the discovery of new genes of industrial enzymes. We exhume and study the new genes with specific functions based on metagenomic sequencing technology which avoid the process of isolating and culturing of microorganisms, expand the use space of microbial resources. We will use bioinformatics to analyze the data from metagenomic sequencing and other database, and try to looking for the gene sequence characteristics of some particular family of enzymes. Combing the methods of genomic information and experimental validation to study new genes of enzyme and metabolic pathways, providing the information for new genes design and reform.
Selected Publications
1. Liu G, Jiang Y, Wang P, Feng R, Jiang N, Chen X, Song H, Chen Z: Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies. J Neurochem 120:190-198, 2012.
2. Ping Wang, Lele Hu, Guiyou Liu, Nan Jiang, Xiaoyun Chen, JianyongXu, Wen Zheng, Li Li, Ming Tan, Zugen Chen, Hui Song, Yu-Dong Cai, Kuo-Chen Chou. Prediction of Antimicrobial Peptides Based on Sequence Alignment and Feature Selection Methods. PLoS ONE 2011，6(4): 1847. doi:10.1371/journal.pone.0018476
3. Shaojing Sun, Fuping Lu，Hui Song, Jianyong Xu, Nan Jiang, Yueling Zhang,Li Li, Tan Ming, Wen Zheng Cloning, expression and characterization of a thermostable pullulanase from newly isolated thermophilic Geobacillus sp. LM14-3，CISP-BMEI 2011
4. Yuanxia Sun, Yin Li, Hui Song and Yang Zhu. Microbial Fermentation for Food Preservation，Natural Antimicrobials in Food Safety and Quality，2011
5. Li LX，Yuan RH，Song H，Naples M，Ye FL，Shofi S，Adeli L，Ng DS. LCAT deficient mice develop improved hepatic insulin sensitivity through altered Regulation of transcription factors and suppressors of cytokine signaling. Am J PhysiolEndocrinolMetab. 2007 Aug；293(2)：E587-94.
6. Heinrich JE，Rollard M，Walter WA，Liang Z，Song H，Rosen ED，Suckow MA. Vaccination against prostate cancer using a live tissue factor deficient cell line in Lobund-Wistarrats. Cancer Immunol Immunother. 2007；56：725-730
7. Song H，Zhu L，Picardo CM，Maguire G ，Leung V，Connelly PW，Ng DS. Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT null mice is associated with altered PUFA metabolism. Am J PhysiolEndocrinolMetab. 2006 Jan；290(1)：E17-E25.
