ZHUDunming, Ph.D.  Investigator and Vice President, TIB, Tianjin, China  Tel: 0086-22-84861962  E-mail: zhu_dm(AT)tib.cas.cn

 

Education and Professional Experients

Ph.D. Vice Presi of State Engineering Laboratory for Industrial Enzymes. He got his BS from the University of Science & Technology of China and his Ph.D. from Shanghai Institute of Organic Chemistry, CAS. Before joining TIB, he held several positions in academia and industry in the United States. He has co-authored more than 70 peer-reviewed articles in core international journals including JACS, Organic Letters and Advanced Synthesis& Catalysis. He received a First Class Award in Natural Science bythe CAS in 1995, a Third Class Award in Natural Science by the Chinese National Committee of Science and Technology in 1997, and the Tetrahedron: Asymmetry Most Cited Paper 2004–2007 Award and 2005–2008 Award by Elsevier Ltd., Oxford, UK. He is an Editorial Board Member of Journal of Molecular Catalysis B: Enzymatic, and Chinese Journal of Biotechnology. 

Research Interest

His research interest ranges from discovery of novel industrial enzymes to understanding of biocatalyticreaction mechanisms, and the integration of biocatalysis intocomplex organic synthesis.

Selected Publications

1.  W. Liu, Z. Li, C.-H. Huang, R.-T.Guo, L. Zhao, D. Zhang, X. Chen, Q. Wu, D. Zhu, “Structural and Mutational Studies on the Unusual Substrate Specificity of meso-Diaminopimelate Dehydrogenase from Symbiobacteriumthermophilum”, ChemBioChem, 2014, in press.
2.  G. Li, J. Ren, H. Iwaki, D. Zhang, Y. Hasegawa, Q. Wu, J. Feng, P.C.K. Lau, D. Zhu, “Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines”, Applied Microbiology and Biotechnology, 2014, in press.
3.  X. Gao, F. Huang, J. Feng, X. Chen, H. Zhang, Z. Wang, Q. Wu, D. Zhu, “Engineering the meso-Diaminopimelate Dehydrogenase from Symbiobacteriumthermophilum by Site-Saturation Mutagenesis for D-Phenylalanine Synthesis”, Applied and Environmental Microbiology, 2013, 79, 5078-5081.
4.  X. Liu, Q. Zhao, J. Ren, W. Dong, Q. Wu, D. Zhu, “N-terminal truncation of a maleate cis-transisomerase from Rhodococcus sp. RHA1 results in a highly active enzyme for the biocatalytic production of fumaric acid”, Journal of Molecular Catalysis B. Enzymatic, 2013, 93, 44-50.
5.  X. Gao, X. Chen, W. Liu, J. Feng, Q. Wu, L. Hua, D. Zhu, “ANovel meso-DiaminopimelateDehydrogenase from Symbiobacteriumthermophilum. Overexpression, Characterizationand Potential for D-amino Acid Synthesis”, Applied and Environmental Microbiology, 2012, 78, 8595-8600.
6.  J.Ren, W. Dong,B. Yu, Q. Wu, D. Zhu, “Synthesis of Optically Active α-Bromohydrins via Reduction of α-Bromoacetophenone Analogues Catalyzed by an Isolated Carbonyl Reductase”, Tetrahedron: Asymmetry, 2012, 23, 497-500.
7.  H. Li, Y. Yang, D. Zhu, L. Hua and K. Kantardjieff, “Highly Enantioselective Mutant Carbonyl Reductases Created via Structure-Based Site-Saturation Mutagenesis”, Journal of Organic Chemistry, 2010, 75, 7559-7564.
8.  D. Zhu, J. Li, Q. Wu, “Stereoselective Synthesis Using Marine Enzymes”, in “Marine enzymes for biocatalysis. Sources, biocatalytic characteristics and bioprocesses of marine enzymes”, Edited by A.Trincone, 2013, Woodhead Publishing (Oxford), pp237-258.