Our research focuses on the interdisciplinary frontiers of synthetic biology and metabolic engineering. Major research interests include elucidating the biosynthetic mechanisms of natural products, engineering subcellular compartmentalization strategies for synthetic metabolic engineering, establishing an Artificial Herbal Science System for the design and biosynthesis of multi-target natural product-based therapeutics, and developing advanced in vivo drug delivery systems for therapeutic applications.
2007.09–2010.07, Ph.D., Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences.
2010.07–Present, Assistant Professor, Associate Professor, and currently Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (TIB, CAS).
2023.08-Present, Secretary-General, Molecular Pharmacognosy Committee, Chinese Association of Integrative Medicine (CAIM).
2020.10-Present, Vice Chair, Fermented Traditional Chinese Medicine Committee, China Association of Traditional Chinese Medicine.
1. First Prize, Science and Technology Award, Chinese Pharmaceutical Association (Tanshinone Biosynthesis Project)
2. First Prize, Science and Technology Award, Chinese Association of Integrative Medicine (Ginseng Yeast Project)
3. China Government Publishing Award for contribution to the textbook Molecular Pharmacognosy
4. Selected for the Science and Technology Innovation China Leading Technology List for the KH617 Biosynthesis Project
1. Rongsheng Li, Shuang Guo, Dong Wang, Tingting Yang, Wenhao Li, Jie Wang, Luqi Huang，Xueli Zhang* and Zhubo Dai*, Elucidation of the plant progesterone biosynthetic pathway and its application in a yeast cell factory. Metabolic Engineering, 2025. 90:197-208.
2. Rongsheng Li, Jie Wang, Yuanyuan Han and Zhubo Dai*, Compound Danshen Yeast 1.0, STCM, 2024,2(4):303-311.
3. Liping Xu, Dong Wang, Jing chen, Bo Li, Qingyan Li, Pingping Liu, Ying Qin, Changhao Bi, Zhubo Dai*, Feiyu Fan*, Xueli Zhang*, Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production, Metabolic Engineering, 2022, 70：115–128
4. Yusong Shi, Dong Wang, Rongsheng Li, Luqi Huang, Zhubo Dai* and Xueli Zhang*, Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides, Metabolic Engineering, 2021, 67: 104-111.
5. Dong Wang, Jinhe Wang, Yusong Shi, Rongsheng Li, Feiyu Fan, Yin Huang, Weixian Li, Ning Chen, Luqi Huang, Zhubo Dai* and Xueli Zhang*, Elucidation of the complete biosynthetic pathway of the main triterpene glycosylation products of Panax notoginseng using a synthetic biology platform, Metabolic Engineering, 2020, 61:131-140.
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