Name: Wang Huiying
Title: Associate Professor
Tel: 0086-22-84861945
E-mail: wanghuiying@tib.cas.cn
Engaged in the creation and industrial application research of core industrial microbial strains, including developing efficient genome editing tools, elucidating the mechanism underlying high vitamin B12 production in Sinorhizobium meliloti, metabolically engineering strains for high vitamin B12 productivity, and constructing high-throughput screening platforms for vitamin B12.
Education
2013.9 to 2019.6，PhD, School of Life Sciences and Biotechnology, Nankai University，China
2009.9 to 2013.6, B.S., School of Life Sciences and Biotechnology, Nankai University，China
Professional Experience
2025.10 to present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Associate Researcher
2024.12 to 2025.9, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Research Assistant
2019.6 to 2024.12, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, postdoc
Representative Articles from the Past Five Years:
1. Liu X1, Dong H1, Wang H1, Ren X, Yang X, Li T, Fu G, Xia M, Fang H, Du G, Jin Z, Zhang D. Recent Advances in Genetic Engineering Strategies of Sinorhizobium meliloti. ACS Synth Biol. 2024 Nov 15;13(11):3497-3506.
2. Yang X1, Wang H1, Ding D, Fang H, Dong H, Zhang D. A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis. Synth Syst Biotechnol. 2024 Apr 13;9(3):513-521.
3. Liu G1, Wang H1, Tong B1, Cui Y, Vonesch SC, Dong H, Zhang D. An Efficient CRISPR/Cas12e System for Genome Editing in Sinorhizobium meliloti. ACS Synth Biol. 2023 Mar 17;12(3):898-903.
4. Dong H1, Wang H1, Fu S, Zhang D. CRISPR/Cas tools for enhancing the biopreservation ability of lactic acid bacteria in aquatic products. Front Bioeng Biotechnol. 2022 Dec 23;10:1114588.
5. Liu L, Ding D, Wang H, Ren X, Lee SY, Zhang D. Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories. Adv Sci (Weinh). 2025 Oct;12(40):e10649.
6. Cui Y1, Dong H1, Tong B, Wang H, Chen X, Liu G, Zhang D. A versatile Cas12k-based genetic engineering toolkit (C12KGET) for metabolic engineering in genetic manipulation-deprived strains. Nucleic Acids Res. 2022 Aug 26;50(15):8961-8973.
Patents Granted:
1. Zhang Dawei; Wang Huiying; Dong Huina; Liu Xuan; Ding Dongqin; A Synthetic Promoter PH and Its Application in Vitamin B12-Producing Strains, 2025-02-06, China, CN Patent ZL202510132997.4.
2. Zhang Dawei; Wang Huiying; Dong Huina; Liu Xuan; Ding Dongqin; A Synthetic Promoter Pw and Its Application in Vitamin B12-Producing Strains, 2025-02-06, China, CN Patent ZL202510132996.X.
3. Zhang Dawei; Wang Huiying; Knockout Strains of Sinorhizobium meliloti with Knocked-Out Transcription Factor, Method for Construction, and Application, 2025-01-24, China, CN Patent ZL202510117135.4.
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Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
