Prof Weidong Liu has been working on protein engineering for decades, using structure biology technique to solve the three-dimensional structure and illustrate the structure and function relationship of Industrial important enzymes.

Study experience:

2001.09-2005.06, Bachelor in Biological Sciences, School of Life Sciences, Nanjing Agricultural University

2005.09-2010.06, PhD in Microbiology, School of Life Sciences, Nanjing Agricultural University

Work experience:

2010.07-2014.03, Assistant Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2014.04-2020.07, Associate Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2020.02-2021.01, Visiting Scholar, Greifswald University, Germany

2020.08 - now, Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Tianjin Natural Science Foundation, Second prize 4/8

Youth Innovation Promotion Association of the Chinese Academy of Sciences

(1) Pfaff, L.; Gao, J.; Li, Z.; Jäckering, A.; Weber, G.; Mican, J.; Chen, Y.; Dong, W.; Han, X.; Feiler, C. G.; Ao, Y.-F.; Badenhorst, C. P. S.; Bednar, D.; Palm, G. J.; Lammers, M.; Damborsky, J.; Strodel, B.; Liu, W.*; Bornscheuer, U. T.*; Wei, R.*, Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase. ACS Catal 2022, 12 (15), 9790-9800.

(2) Wu, L.; An, J.; Jing, X.; Chen, C.-C.; Dai, L.; Xu, Y.; Liu, W.*; Guo, R.-T.*; Nie, Y.*, Molecular Insights into the Regioselectivity of the Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Catalyzed C–H Hydroxylation of Amino Acids. ACS Catal 2022, 11586-11596.

(3) Li, J.; Yang, J.; Mu, S.; Shang, N.; Liu, C.; Zhu, Y.; Cai, Y.; Liu, P.; Lin, J.; Liu, W.*; Sun, Y.;* Ma, Y.* Efficient O-glycosylation of triterpenes enabled by protein engineering of plant glycosyltransferase UGT74AC1. ACS Catal. 2020, 10, 3629-3639.

(4) Chen, C.C.; Hu, X.; Tang, X.; Yang, Y; Ko, T. P.; Gao, J.; Zheng, Y.; Huang, J. W.; Yu, Z.; Li, L.; Han, S.; Cai, N.; Zhang, Y.; Liu, W.*; Guo, R. T.* The Crystal Structure of a class of cyclases that catalyze the cope rearrangement. Angew. Chem. Int. Ed. 2018, 57, 15060-15064.

(5) Han, X.;# Liu, W.#; Huang, J.-W.#; Ma, J.; Zheng, Y.; Ko, T.-P.; Xu, L.; Cheng, Y.-S., Chen, C.-C., Guo, R.-T. Structural insight into catalytic mechanism of PET hydrolase. Nat. Commun. 2017, 8, 2106.

1. Sub project of National Key Research and Development, Crystal Structure Analysis of Refractory Toxic Pollutant Degrading Enzyme, 2019.01-2024.12

2. National Key Research and Development Program Project, Structural Remodeling and Functional Expansion of Receptor Proteins and Nucleases, 2021.12-2026.11

3. Tianjin Synthetic Biotechnology Innovation Capability Improvement Action, Industrial Protein Research and Service Platform, 2021.10-2023.12

4. National Natural Science Foundation of China, Research on the Catalytic Mechanism of Polyurethane Plastic Depolymerase, 2024.01-2027.12

5. National Natural Science Foundation of China, Functional Research of Mycobacterium Tuberculosis Ten Isoprene Pyrophosphate Synthase and Development of Anti Tuberculosis Drugs, 2016.01-2019.12

6. National Natural Science Foundation of China, Youth Science Foundation Project, Chiral Selectivity Modification and Mechanism Research of L-Amino Acid Dehydrogenase, 2012.01-2014.12