Title:Sun Yuanxia
Tel:022-84861961
E-mail:sun_yx@tib.cas.cn
Our group focuses on effective utilization of bioresources and production of bioactive substances, such as rare sugar, polyol, polysaccharide, microbial Protein, and sugar-protein complex. We are using enzyme and bio-catalysis engineering technology to develop these functional sugars and bioactive compounds as food additives. We have also contributed structural and functional support to a project of glycated proteins aimed at characterizing important sugar-protein complexes. The mission of the lab is to establish a bio-catalysis technical platform for transforming the bioresources into the novel active substance, and to construct innovative low-carbon and green biological manufacturing technology routes for healthy sugars.
1981-1985 Biological Department, Harbin Normal University, China
1993-1996 Department of Animal Science, Northeast Agricultural University, China
1999-2002 Utilization of Bioresources, Ehime University, Japan
2002-2008 Rare Sugar Research Center, Kagawa University, Japan
Kagawa Industry Support Foundation, Japan
Postdoctoral Fellow, Visiting Scientist, Researcher
2008- Tianjin Institute of Industrial Biotechnology, CAS, Professor
Received 5 awards including the Tianjin Science and Technology Progress Award, the Outstanding Contribution Award for Industry, University, and Research Innovation and Development.
1) Yang J., et al. De novo artificial synthesis of hexoses from carbon dioxide. Science Bulletin, 2023, 68(20), 2370-2381.
2) Tian C., et al. Engineering substrate specificity of HAD phosphatases and multienzyme systems development for the thermodynamic-driven manufacturing sugars. Nature Communication, 2022, 13, 3582
3) Zhang T., et al. Protein engineering of glucosylglycerol phosphorylase facilitating efficient and highly regio- and stereoselective glycosylation of polyols in a synthetic system ACS Catalysis 2022, 12, 24
4) Li J., et al. Glycosyltransferase engineering and multi-glycosylation routes development facilitating synthesis of high-intensity sweetener mogrosides iScience, 2022, 25(10), 105222
5) Li J., et al. Efficient O-glycosylation of triterpenes enabled by protein engineering of plant glycosytransferase UGT7AC1ACS Catalysis. 2020, 10(6): 3624-3639.
6) Cai T., et al. Cell-free chemoenzymatic starch synthesis from carbon dioxide. Science, 2021, 373: 1523-1527.
7) Tian C., et al. Artificially designed routes for the conversion of starch to value-added mannosyl compounds through coupling in vitro and in vivo metabolic engineering strategies. Metabolic Engineering, 2020, 61: 215-224.
8) Yang J., et al. Multi-enzyme systems and recombinant cells for synthesis of valuable saccharides: Advances and perspectives. Biotechnology Advances, 2019, 37: 107406.
We have undertaken more than 20 projects, including the National Natural Science Foundation of China, National Key R&D Program of China, and major scientific and technological research projects in Tianjin.
Copyright ©, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China
Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
