Synthetic biology-driven customization of functional nutritional resources/Yeast directed genome evolution

Our team aims to leverage the magic power of synthetic biology and metabolic engineering to customize cell factories to

1. stably supply high-quality protein resources to the rapidly growing global population;
2. efficiently produce active plant natural products to ensure the health of humans and economic animals.

To achieve this goal, we develop advanced technologies to genetically edit and high-throughput screen strains and identify the genotype-to-phenotype relationship. We decompose and reprogram the complex biological machinery, iteratively generating superior yeast cell factories that efficiently convert renewable feedstock to functional nutritional resources.

2022.10 – present Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Investigator/Professor/Supervisor of Ph.D students

2021.06 – 2022.09 Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Associate Investigator/Supervisor of Ph.D students

2018.06 – 2021.05 Co-supervisor of Ph.D/Master/bachelor students, Technical University of Denmark

2018.03 – 2021.05 Postdoctoral research associate, Technical University of Denmark

2016.01- 2018.01 Postdoctoral research associate, Chalmers University of Technology

2012.09 – 2015.12 Doctor of Science (D. Sc) in Biochemical Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2014.07 – 2015.05 Visiting student at the Department of Biological System Engineering, Washington State University

2009.09 – 2012.07 Master of Science (M.S.) in Botany, Shandong Agricultural University

2005.09 – 2009.07 Bachelor of Science (BS) in Biological Science, Shandong Agricultural University

2021 Excellent Young Scholar from NSFC

2014, 2015 Merit Student of University of Chinese Academy of Sciences

2012 Excellent Master Thesis of Shandong Agricultural University

2011 Excellent Cadres of Graduate Student of Shandong Agricultural University

2011 Scholarship for Excellent Graduate Students of Shandong Agricultural University

2005-2008 Scholarship for Excellent Students of Shandong Agricultural University

Wang G*, Wu X*, Yin Y*. (2022) Synthetic biology-driven customization of functional feed resources. Trends in Biotechnololy. 40 (7): 777-780.

Wang G, Tavares A, Schmitz S, Franca L, Almeida H, Cavalheiro J, Carolas A, Ozmerih S, Blank LM, Ferreira BS*, Borodina I*. (2022) An integrated yeast-based process for cis,cis-muconic acid production. Biotechnology Bioengineering. 119, 376-387

Wang G*, Olofsson-Dolk M, Hansson FG, Donati S, Li X, Chang H, Cheng J, Dahlin J, Borodina I*. (2021) Engineering yeast Yarrowia lipolytica for methanol assimilation. ACS Synthetic Biology. 10, 3537-3550

Wang G*, Kell DB, Borodina I*. (2021) Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites. Essays in Biochemistry. 65, 277-291

Wang G,Hansen IM, Babaei M, D'ambrosio V, Christensen HB, Darbani B, Jensen MK, Borodina I*. (2021) Transportome-wide engineering of Saccharomyces cerevisiae. Metabolic Engineering. 64:52-63

Sáez-Sáez J, Wang G*, Marella ER, Sudarsan S, Pastor MC, Borodina I*. (2020) Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production. Metabolic Engineering, 62:51-61

Wang G, Ozmerih S, Guerreiro R, Meireles AC, Milne N, Jensen MK, Ferreira BS, Borodina I*. (2020) Improvement of cis,cis-muconic acid production in Saccharomyces cerevisiae through biosensor-aided engineering, ACS Synthetic Biology, 9 (3): 634-646

Wang G, Bjork S, Huang M, Liu Q, Campbell K, Nielsen J, Jonsson H*, Petranovic D*. (2019) RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae, Proceedings of the National Academy of Sciences, 116(19), 9324-9332.

Wang G, Jia W, Chen N, Zhang K, Wang L, Lv P, He R, Wang M, Zhang D*. (2018) A GFP-fusion coupling FACS platform for advancing the metabolic engineering of filamentous fungi, Biotechnology for Biofuels; 11:232

Wang G#, Huang M#, Nielsen J*. (2017) Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production, Current Opinion in Biotechnology; 48:77-84

Wang G,Xiong X, Ghogare R, Wang P, Meng Y, Chen S*. (2016) Exploring fatty alcohol-producing capability of Yarrowia lipolytica. Biotechnology for Biofuels; 9:107.

Wang G, Lv P, He R, Wang H, Wang L, Zhang D*, Chen S*. (2015) Protein disulfide isomerase homolog TrPDI2 contributing to cellobiohydrolase production in Trichoderma reesei. Enzyme and Microbial Technology; 77:21-28.

Wang G,Wang H, Xiong X, Chen S, Zhang D*. (2015) Mitochondria thioredoxin's backup role in oxidative stress resistance in Trichoderma reesei. Microbiological Research; 171:32-38.

Wang G, Zhang D, Chen S*. (2014) Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30. World Journal of Microbiology & Biotechnology; 30:2587-2595.

Wang G, Zhang M, Gong J, Guo Q, Feng Y, Wang W*. (2012) Increased gibberellin contents contribute to accelerated growth and development of transgenic tobacco overexpressing a wheat ubiquitin gene. Plant Cell Rep 31 (12):2215-2227.

Principal investigator of National Natural Science Fund for Excellent Young Scientists Fund Program (Overseas),

Principal investigator of National Natural Science Foundation of China (General Program),

Principal investigator of Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project,

Principal investigator of Talent Program, Chinese Academy of Sciences

Main participant of Strategy Priority Research Program (Category C) of Chinese Academy of Sciences