Title:Wang Qinhong
Fax:022-84861950
E-mail:wang_qh@tib.cas.cn
My research group is interested in engineering microbial cell factories by novel editing/evolution strategies to improve the production of bio-based products based on constructing and optimizing metabolic pathways, and then characterizing the novel microbial cell factories by a variety of biochemical and biophysical methods (e.g. functional omics tools) to elucidate the underlying molecular mechanism, which will contribute to finding the useful targets for next-round engineering microbial cell factories for further improving their performance, such as titer, yield and productivity..
2009.6-present Principal Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2005.7-2009.4 Postdoctoral Scholar, California Institute of Technology, Pasadena, California, USA
2004.1-2005.6 Postdoctoral Research Associate, University of Oklahoma, Norma, Oklahoma, USA
1999.9-2003.3 Ph.D. in Biochemistry and Molecular Biology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
1996.9-1999.4 Master in Engineering, Henan University of Technology, Zhengzhou, China
1992.9-1996.6 Bachelor in Engineering, Henan University of Technology, Zhengzhou, China
1. Tianjin Teaching Achievement Award, 2022.
2. The editorial board member of the year for Chinese Journal of Biotechnology, 2022, 2021, and 2019.
3. Special government allowance of The State Council, 2018.
4. Tianjin May 1st Labor Medal, 2016.
1. Wang Z, Lin Y, Dai Z, Wang Q*. Modulating DNA Repair Pathways to Diversify genomic alterations in Saccharomyces cerevisiae. Microbiology Spectrum 2022, 10(2):e0232621.
2. Yuan H, Zhou Y, Lin Y, Tu R, Guo Y, Zhang Y, Wang Q*. Microfluidic screening and genomic mutation identification for enhancing cellulase production in Pichia pastoris. Biotechnology for Biofuels and Bioproducts 2022, 15(1):50.
3. Yuan H, Tu R, Tong X, Lin Y, Zhang Y, Wang Q*. Ultrahigh-throughput screening of industrial enzyme-producing strains by droplet-based microfluidics system. Journal of Industrial Microbiology & Biotechnology 2022, 49(3):kuac007.
4. Gan Y, Qi X, Lin Y*, Guo Y, Zhang Y, Wang Q*. A hierarchical transcriptional regulatory network required for long-term thermal stress tolerance in an industrial Saccharomyces cerevisiae Strain. Frontiers in Bioengineering and Biotechnology. 2022, 9:826238.
5. Yang J, Tu R, Yuan H, Wang Q*, Zhu L*. Recent advances in droplet microfluidics for enzyme and cell factory engineering. Critical Reviews in Biotechnology 2021, 41(7):1023-1045.
6. Liu Y, Lin Y*, Guo Y, Wu F, Zhang Y, Qi X, Wang Z, Wang Q*. Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae. Biotechnology for Biofuels 2021, 14(1):155.
7. Wu F, Chen W, Peng Y, Tu R, Lin Y, Xing J, Wang Q*. Design and reconstruction of regulatory parts for fast-frowing Vibrio natriegens Synthetic Biology. Acs Synthetic Biology 2020, 9(9):2399-2409.
8. Cheng J, Hu G, Xu Y, Torrens-Spence MP, Zhou X, Wang D*, Weng JK*, Wang Q*. Production of nonnatural straight-chain amino acid 6-aminocaproate via an artificial iterative carbon-chain-extension cycle. Metabolic Engineering 2019, 55:23-32.
9. Wang Z, Qi Q, Lin Y, Guo Y, Liu Y*, Wang Q*. QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast. Biotechnology for Biofuels 2019, 12:59.
10. Li L, Tu R*, Song G, Cheng J, Chen W, Li L, Wang L, Wang Q*. Development of a synthetic 3-dehydroshikimate biosensor in Escherichia coli for metabolite monitoring and genetic screening. ACS Synthetic Biology 2019, 8(2):297-306.
11. Xiao W, Duan X, Lin Y, Cao Q, Li S, Guo Y, Gan Y, Qi X, Zhou Y, Guo L, Qin P, Wang Q*, Shui W*. Distinct proteome remodeling of industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock. Journal of Proteome Research 2018, 17(5):1812-1825.
12. Xiong Y, Guo Y, Xiao W, Cao Q, Li S, Qi X, Zhang Z, Wang Q*, Shui W*. An NGS-independent strategy for proteome-wide identification of single amino acid polymorphisms by mass spectrometry. Analytical Chemistry 2016, 88(5):2784-2791.
13. Zhang G, Lin Y, Qi X, Li L, Wang Q*, Ma Y. TALENs-assisted multiplex editing for accelerated genome evolution to improve yeast phenotypes. ACS Synthetic Biology 2015, 4(10):1101-11.
14. Zhang G, Lin Y, Qi X, Wang L, He P, Wang Q*, Ma Y. Genome shuffling of the nonconventional yeast Pichia anomala for improved sugar alcohol production. Microbial Cell Factories 2015, 14:112.
1. National Key Research and Development Program of China, Development and application of high-throughput breeding technologies and equipment for industrial strains, 2021.12-2024.11
2. National Basic Research Program of China (973 Program), Construction and optimization of synthetic cell factory for the production of adipic acid, 2011.01-2015.08
3. National Major Scientific and Technological Special Project for “Significant New Drugs Development”, Synthetic biology of protocatechuic acid, salidroside, and breviscapine, 2018.01-2020.12
4. National Natural Science Foundation of China (General Program), Towards a science of multiple stress tolerance improvement in Saccharomyces cerevisiae by multiplex genome editing, 2015.01-2018.12
5. National Natural Science Foundation of China(General Program), Toward a science of glucose repression and metabolic regulation in xylose fermenting candida maltose, 2013.01-2016.12
6. The Science and Technology Service Network (STS) Initiative of the Chinese Academy of Sciences (CAS), Research and development of bio-manufacturing technology for transformative chemicals, 2019.01-2020.12
7. The Key Research Program of the Chinese Academy of Sciences, Development and application of key technologies for green bioprocessing, 2013.01-2015.12
8. The Instrument Developing Project of the Chinese Academy of Sciences, Development of droplet microfluidic-based high-throughput screening systems with multiple detections for microorganisms, 2018.01-2019.12
9. Industrial Biotechnology Program of Tianjin Municipal Science and Technology Commission, Development of droplet-based microfluidic system for the high-throughput screening of industrial microorganisms, 2014.10-2017.09
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Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
