Professor
Wu Qiaqing

Title:Wu Qiaqing

Tel:022-84861963

E-mail:Wu_qq@tib.cas.cn

Research Interest

Biocatalysis and green chemicals

Education & Professional Experience

2009.6 – present  Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

1992.07-2009.05  Chengdu Institute of Biology, Chinese Academy of Sciences / Chengdu Di-AoPharmaceutical Group Co., Ltd, Chengdu, China, Assistant Professor(1993), AssociateProfessor(1998), Professor(2006)

2001.09-2004.07 PhD West China Hospital, Sichuan University)

1989.09-1992.06 MSc, Department of Biology, Sichuan University, China

1986.07-1989.08 Librarian, Huaibei Coal Normal University, Anhui, China

1982.09-1986.06 BSc, Department of Biology, Sichuan University, China

Honors and Awards

1. First-class Scientific and Technological Progress Award of Zhejiang Province
 (2022, Ranked fourth)

Selected Publications

1. Liu Y, Zhu L, Li X, Cui Y, Roosta A, Feng J*, Chen X,Yao P, Wu Q*, Zhu D*(2023)Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetroc C-C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols.

JACS Au, https://doi.org/10.1021/jacsau.3c00366.

2. Xu Z, Feng J, Yao P, * Wu Q * and Zhu D*(2023)Chemo-enzymatic Synthesis of Chiral 3-substituted Tetrahydroquinolines by a Sequential Biocatalytic Cascade and Buchwald–Hartwig Cyclization. Green Chem., 25: 4667-4673

3. Zhou C, Chen X,* Lv T, Han X, Feng J, Liu W, Wu Q,* Zhu D* (2023) Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4‑Aryl-2-oxazolidinones from Readily Available Epoxides.  ACS Catal., 13: 4768-77 doi.org/10.1021/acscatal.2c06417

4. Feng J, Wu Q, Zhu D*, Ma Y (2022) Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals. ChemSusChem, e202102399 doi:10.1002/cssc.202102399

5. Wang Y, Zhang R, Feng J, Wu Q*, Zhu D*, Ma Y (2022) A New 3-Ketosteroid-Delta(1)-Dehydrogenase with High Activity and Broad Substrate Scope for Efficient Transformation of Hydrocortisone at High Substrate Concentration. Microorganisms 10(3) doi:10.3390/microorganisms10030508

6. Li Y, Hu N, Xu Z, Cui Y, Feng J, Yao P*, Wu Q*, Zhu D*, Ma Y (2022) Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.  Angew. Chem. Int. Ed. 61(17):e202116344 doi:10.1002/anie.202116344

7. Liu N, Wu L, Feng J, Sheng X, Li J, Chen X, Li J, Liu W, Zhou J*, Wu Q*, Zhu D* (2021) Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew. Chem. Int. Ed. 60: 10203-10210 doi:10.1002/anie.202017225

8. Yu S, Li J, Yao P, Feng J, Cui Y, Li J, Liu X, Wu Q*, Lin J*, Zhu D* (2021) Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy. Angew. Chem. Int. Ed., 60(7): 3679-3684 doi:10.1002/anie.202012243

9. Xu Z, Yao P, Sheng X, Li J, Li J, Yu S, Feng J, Wu Q*, Zhu D* (2020) Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination. ACS Catal. 10(15): 8780-8787 doi:10.1021/acscatal.0c02400

10. Chen X, Zhang H, Maria-Solano MA, Liu W, Li J, Feng J, Liu X, Osuna S*, Guo R-T, Wu Q*, Zhu D*, Ma Y (2019) Efficient Reductive Desymmetrization of Bulky 1,3-cyclodiketones Enabled by Structure-guided Directed Evolution of a Carbonyl Reductase. Nat. Catal. 2(10): 931-941 doi:10.1038/s41929-019-0347-y5

11. Liu N, Feng J, Zhang R, Chen X, Li X, Yao P, Wu Q*, Ma Y, Zhu D* (2019) Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains. Green Chem. 21(15): 4076-4083 doi:10.1039/c9gc01267b

Project

1. Subject Leader, National Key R&D Program of China
 (No.2019YFA0905300)

2. Project Leader, Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (2019,TSBICIP-KJGG-001),

3. Subject Leader, National Key R&D Program of China
(No.2021YFC2102000)