Research in our group are mainly focused on: (1) microbial natural products drug discovery and production; (2) biosynthesis and resistance mechanisms of natural products; and (3) preparation of ‘unnatural’ natural products; to help tackle the antimicrobial resistance problems. We’re an interdisplinary research team with folks from synthetic biology, biochemistry, chemical biology, bioinformatics, natural product chemistry and medicinal chemistry working together to develop new antibiotics and new antimicrobial therapeutics.
2006.09-2010.07 School of Bioengineering, East China University of Science and Technology, Bachelor
2010.09-2017.03 School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Ph.D
2017.07-2023.01 Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Postdoc
2023.02-to date Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Professor
1. Koteva, K.#, Min, X.#, Wenliang, W., Fiebig, A., Cook, M., Coombes, B.K. & Wright, G.D. Synthetic Biology Facilitates Semi-Synthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin Resistant Enterococcus. J. Med. Chem. 2023; 66(13):9006-9022.
2. Anwei, H.*, Bei, L., Zixin, D., Min, X.* & Dickschat, J.S.* Cladosporin, A Highly Potent Antimalaria Drug? ChembioChem. 2023; 24(12):e202300154.
3. Min, X., Wenliang, W., Waglechner, N., Culp, E.J., Guitor, A.K. & Wright, G.D. Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics. ACS Cent. Sci. 2022; 8(5), 615-626.
4. Alder A., Struck N.S., Min, X., Johnson J.W., Wenliang, W., Pallant, D., Cook, M.A., Rambow, J., Lemcke, S., Gilberger, T.W. & Wright, G.D. A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. Cell Chem. Biol. 2022; 29(5):840-853.
5. Min, X., Wenliang, W. & Wright, G.D. Glycopeptide antibiotic discovery in the genomic era. Methods Enzymol. 2022; 665:325-346.
6. Min, X., Wenliang, W., Waglechner, N., Culp, E.J., Guitor, A.K. & Wright, G.D. GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery. Nat. Commun. 2020; 11, 5232.
7. Min, X.#, Fei, Z.#, Zhuo, C., Bashiri, G., Jing, W., Jiali, H., Yemin, W., Lijun, X., Xuefei, C., Shengxiong, H., Shuangjun, L., Zixin, D. & Meifeng, T. Functional Genome Mining Reveals a Class V Lanthipeptide Containing a d‐Amino Acid Introduced by an F420H2‐Dependent Reductase. Angew. Chem. Int. Ed. 2020; 59, 18029– 18035.
8. Min, X. & Wright, G. D. Heterologous expression-facilitated natural products’ discovery in actinomycetes. J. Ind. Microbiol. Biotechnol. 2019; 46, 415–431.
9. Xuefei, C., Min, X., Jin, L., Jianguo, X., Yemin, W., Shuangjun, L., Zixin, D. & Meifeng, T. Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring. Appl. Environ. Microbiol. 2018; 84(12), e00349-18.
10. Xiangyang, L., Dongxu, L., Min, X., Meifeng, T., Linquan, B., Zixin, D., Pfeifer, B.A. & Ming, J. Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074. J. Nat. Prod. 2018; 81(1), 72-77.
11. Guixi, G., Xiangyang, L., Min, X., Yemin, W., Fei, Z., Lijun, X., Jin, L., Qingshan, L., Qianjin, K., Hongyu, O., Ying, W., Rohr, J., Zixin, D., Ming, J., Shuangjun, L. & Meifeng, T. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement. Cell Chem. Biol. 2017; 24(7), 881–891.
12. Xiaoqing, Z., Qiuxiang, C., Fen, Y., Xiaozheng, W., Lingxin, K., Bo, C., Min, X., Shuangjun, L., Zixin, D., Chooi, Y.H. & Delin, Y. Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. PNAS. 2017; 114(16), 4135–4140.
13. Zhilong, Z., Ting, S., Min, X., Brock, N.L., Yilei, Z., Yemin, W., Zixin, D., Xiuhua, P. & Meifeng, T. Hybrubins: bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes. Org. Lett. 2016; 18, 572-575.
14. Min, X., Yemin, W., Zhilong, Z., Guixi, G., Shengxiong, H., Qianjin, K., Xinyi, H., Shuangjun, L., Xiuhua, P., Zixin, D. & Meifeng T. Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole Genome Bacterial Artificial Chromosome Library in Streptomyces spp. Appl. Environ. Microbiol. 2016; 82(19), 5795-5805.
15. Li, C., Yemin, W., Hang, G., Min, X., Zixin, D. & Meifeng T. High-Throughput Screening for Streptomyces Antibiotic Biosynthesis Activators. Appl. Environ. Microbiol. 2012; 78(12), 4526–4528.
Major Project of the Haihe Laboratory of Synthetic Biology, 2022.08-2025.06
Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project, 2023.05-2026.05
National Key R&D Program of China, 2023.12-2028.11
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