Dr. Yao’s research interest includes the design, mechanism and application of novel biocatalytic reactions. He has developed lots of novel, efficient and green chemoenzymatic methods for the precise construction of chiral centers of important and complex molecules, which have been successfully applied to synthesize key intermediates of pharmaceuticals and materials, promoting the green upgrading of the production technologies of related drugs and materials.
Dr Yao has published over 30 peer-reviewed papers as the first or corresponding author in Nat. Chem.、Angew. Chem. Int. Ed.、ACS Catal.、Green Chem.、Chem Catal.、Sci. China Chem.、Chem. Sci., Org. Lett. etc., and filed over 10 patents.
2022.6 to present, Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2018.9 to 2019.8, visiting scholar, the University of Manchester, UK,
2016.10 to 2022.6, Associate Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2012.11 to 2016.10, Assistant Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2012.9 to 2012.11, Senior Scientist, WuXi AppTec (Tianjin), China
2010.7 to 2012.8, R&D Director, Yantai Tongtai Drug Research Co., LTD, China
2009.5 to 2010.4，visiting scholar, GlaxoSmithKline, US
2007.9 to 2010.6, PhD, School of Pharmaceutical Science and Technology, Tianjin University, China
2004.9 to 2007.3, MSc, School of Pharmaceutical Science and Technology, Tianjin University, China
2000.9 to 2004.6, BSc, College of Chemistry, Nankai University, China
2021, Royal Society of Chemistry (RSC) Horizon Prize：Rita and John Cornforth Award.
1. Z. Xu, J. Feng, P. Yao*, Q. Wu*, D. Zhu*, Green Chem. 2023, 25, 4667-4673, DOI: 10.1039/d3gc00047h.
2. Y. Li#, P. Yao#, S. Zhang, J. Feng, H. Su, X. Liu, X. Sheng, Q. Wu, D. Zhu, Y. Ma*, Chem Catal. 2023, 3, 100467, DOI: 10.1016/j.checat.2022.11.006.
3. T. Liu#, Z. Xu#, J. Feng, S. Yu, M. Wang, P. Yao*, Q. Wu*, D. Zhu*, Org. Lett. 2023, 25, 2438-2443, DOI: 10.1021/acs.orglett.3c00603.
4. Y. Li#, N. Hu#, Z. Xu, Y. Cui, J. Feng, P. Yao*, Q. Wu*, D. Zhu*, Y. Ma. Angew. Chem. Int. Ed. 2022, 61, e202116344, DOI: 10.1002/anie.202116344.
5. L. Yang#, J. Li#, Z. Xu, P. Yao*, Q. Wu, D. Zhu*, Y. Ma*, Org. Lett. 2022, 24, 6531-6536, DOI: 10.1021/acs.orglett.2c02466.
6. Z. Zhan, Z. Xu, S. Yu, J. Feng, F. Liu, P. Yao*, Q. Wu*, D. Zhu*, Adv. Synth. Catal. 2022, 364, 2380-2386, DOI: 10.1002/adsc.202200361.
7. M. Li, Y. Cui, Z. Xu, X. Chen, J. Feng, M. Wang, P. Yao*, Q. Wu*, D. Zhu*. Adv. Synth. Catal. 2022, 364, 372-379, DOI: 10.1002/adsc.202100953.
8. J. R. Marshall#, P. Yao#, S. L. Montgomery, J. D. Finnigan, T. W. Thorpe, R. B. Palmer, J. Mangas-Sanchez, R. A. M. Duncan, R. S. Heath, K. M. Graham, D. J. Cook, S. J. Charnock, N. J. Turner*. Nat. Chem. 2021, 13, 140-148, DOI: 10.1038/s41557-020-00606-w.
9. P. Yao#, J. R. Marshall#, Z. Xu, J. Lim, S. J. Charnock, D. Zhu*, N. J. Turner*. Angew. Chem. Int. Ed. 2021, 60, 8717-8721, DOI: 10.1002/anie.202016589.
10. S. Yu#, J. Li#, P. Yao#, J. Feng, Y. Cui, J. Li, X. Liu, Q. Wu*, J. Lin*, D. Zhu*. Angew. Chem. Int. Ed. 2021, 60, 3679-3684, DOI: 10.1002/anie.202012243.
11. Y. Wang, J. Feng, W. Dong, X. Chen, P. Yao*, Q. Wu*, D. Zhu. ChemCatChem 2021, 13, 3396-3400, DOI: 10.1002/cctc.202100503.
12. Z. Xu#, P. Yao#, X. Sheng, J. Li, J. Li, S. Yu, J. Feng, Q. Wu*, D. Zhu*. ACS Catal. 2020, 10, 8780-8787, DOI: 10.1021/acscatal.0c02400.
13. S. Yu#, P. Yao#, J. Li, J. Feng, Q. Wu*, D. Zhu*. Catal. Sci. Technol. 2019, 9, 1504-1510, DOI: 10.1039/C8CY02455C.
14. P. Yao#, Z. Xu#, S. Yu, Q. Wu*, D. Zhu*. Adv. Synth. Catal. 2019, 361, 556-561, DOI: 10.1002/adsc.201801326.
15. P. Yao#, P. Cong#, R. Gong+, J. Li, G. Li, J. Ren, J. Feng, J. Lin, P. C. K. Lau*, Q. Wu*, D. Zhu*. ACS Catal. 2018, 1648-1652, DOI: 10.1021/acscatal.7b03552.
16. Y. Zhang, P. Yao*, Y. Cui, Q. Wu*, D. Zhu. Adv. Synth. Catal. 2018, 360, 4191-4196, DOI: 10.1002/adsc.201800455.
17. R. Gong, P. Yao*, X. Chen, J. Feng, Q. Wu*, P. C. K. Lau*, D. Zhu, ChemCatChem 2018, 10, 387-390, DOI: 10.1002/cctc.201701229.
18. G. Li#, P. Yao#, R. Gong#, J. Li, P. Liu, R. Lonsdale, Q. Wu, J. Lin*, D. Zhu*, M. T. Reetz*. Chem. Sci. 2017, 8, 4093-4099, DOI: 10.1039/c6sc05381e.
19. P. Yao#, Y. Cui#, S. Yu, Y. Du, J. Feng, Q. Wu*, D. Zhu*, Adv. Synth. Catal. 2016, 358, 2923-2928, DOI: 10.1002/adsc.201600468.
20. P. Yao#, L. Wang#, J. Yuan, L. Cheng, R. Jia, M. Xie, J. Feng, M. Wang, Q. Wu*, D. Zhu*, ChemCatChem 2015, 7, 1438-1444, DOI: 10.1002/cctc.201500061.
21. P. Yao#, J. Li#, J. Yuan, C. Han, X. Liu, J. Feng, Q. Wu*, D. Zhu*, ChemCatChem 2015, 7, 271-275, DOI: 10.1002/cctc.201402877.
22. Y. Duan#, P. Yao#, J. Ren, C. Han, Q. Li, J. Yuan, J. Feng, Q. Wu*, D. Zhu*, Sci. China Chem. 2014, 57, 1164-1171, DOI: 10.1007/s11426-014-5139-2.
1. National Natural Science Foundation of China, Stereoselective control mechanism of imine reductases on amino β-position and precise construction of β-chiral amines, 2022.01-2025.12.
2. National Key R&D Program of China, Ministry of Science and Technology of China, Green biomanufacturing and demonstration of chiral chemicals, 2021.07-2025.06.
3. Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project, Green biosynthesis and demonstration of chemical APIs, 2021.03-2024.03.
4. National Key R&D Program of China, Ministry of Science and Technology of China, Biochemical reaction design and biosynthesis of new molecules, 2020.01-2024.12.
5. Youth Innovation Promotion Association of the Chinese Academy of Sciences, 2016.01-2019.12.
6. Key Project of Tianjin Municipal Science and Technology Support Program, Biomanufacture of ethyl (R)-3-hydroxyglutarate, a key intermediate of lipid-lowering drugs, 2015.04-2017.03.
7. National Natural Science Foundation of China, Catalytic mechanism and rational design of cyclohexylamine oxidase (CHAO), 2014.01-2016.12.
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