Vitamin Biosynthesis, Microbial Cell Factory, Microbial metabolic Engineering, Synthetic Biotechnology, Protein Synthesis and Efficient Expression Systems, Biochemistry
2004-2007 Beijing University of Chemical Technology. Ph.D.
2007-2008 University of Wisconsin Milwaukee. Postdoc.
2008-2012 California Institute of Technology. Postdoc.
2012-present Tianjin Institute of Industrial Biotechnology, CAS. Professor.
National Science Fund for Distinguished Young Scholars in 2023
"the First Class" of Tianjin Science and Technology Progress Award in 2020 (Rank first)
"the Second Class" of Science and Technology Progress Award by China national light industry council in 2020 (Rank first)
"Innovation Award" of China Industry-University-Research Institute Collaboration Association in 2018 (Individual Award)
Tianjin Science and Technology Innovation Leading Talent in 2018
Tianjin Science Fund for Distinguished Young Scholars in 2017
1. Linxia Liu#, Jinlong Li#, Yuanming Gai#, Zhizhong Tian, Yanyan Wang, Tenghe Wang, Pi Liu, Qianqian Yuan, Hongwu Ma, Sang Yup Lee*, Dawei Zhang*. Protein engineering and iterative multimodule optimization for vitamin B6 production in Escherichia coli, Nature Communications. 2023 Aug 31;14(1):5304.
2. Qian Kang, Huan Fang, Mengjie Xiang, Kaixing Xiao, Pingtao Jiang, Chun You, Sang Yup Lee*, Dawei Zhang*. A synthetic cell-free 36-enzyme reaction system for vitamin B(12) production, Nature Communications. 2023 Aug 24;14(1):5177.
3. Jinlong Li#, Sijia Wang#, Cui Liu, Yixin Li, Yu Wei, Gang Fu, Pi Liu, Hongwu Ma, Dawei Huang, Jianping Lin,* and Dawei Zhang*, Going Beyond the Local Catalytic Activity Space of Chitinase Using a Simulation-Based Iterative Saturation Mutagenesis Strategy, ACS Catalysis, 2022, 12, 16, 10235−10244.
4. Yali Cui#, Huina Dong#, Baisong Tong, Huiying Wang, Xipeng Chen, Guangqing Liu, Dawei Zhang*, A versatile Cas12k-based genetic engineering toolkit (C12KGET) for metabolic engineering in genetic manipulation-deprived strains, Nucleic Acids Research. 2022 Aug 26;50(15):8961-8973. doi: 10.1093/nar/gkac655.
5. Gang Fu, Jie Yue, Dandan Li, Yixin Li, Sang Yup Lee*, Dawei Zhang*，An operator-based expression toolkit for Bacillus subtilis enables fine-tuning of gene expression and biosynthetic pathway regulation, Proc Natl Acad Sci U S A. 2022 Mar 15, 119(11):e2119980119.
6. Dongqin Ding#, Jinlong Li#, Danyang Bai, Huan Fang, Jianping Lin*, Dawei Zhang*, Biosensor-based monitoring of the central metabolic pathway metabolites, Biosensors and Bioelectronics. 2020 Nov 1;167: 112456.
7. Huan Fang, Dong Li, Jie Kang, Pingtao Jiang, Jibin Sun, Dawei Zhang*. Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12. Nature Communications. 2018 Nov 21;9(1):4917.
National Science Fund for Distinguished Young Scholars
National Key R&D Program of China
National Natural Science Foundation of China
Tianjin Science Fund for Distinguished Young Scholars
Science and Technology Service Network (STS) initiative of Chinese Academy of Sciences (CAS)
Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project
Enterprise horizontal project
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