Artificial intelligence/computer-aided industrial protein science and biocatalytic engineering:
By combining artificial intelligence/computer-aided technology and biocatalysis and conversion technology, we aim to explore, analyze, and apply the enzyme elements in the direction of biomass sugar to obtain key enzymes with clear catalytic mechanisms, clear speed limiting steps, and significantly improved enzymatic properties, serving the national strategy of sustainable development and "carbon peaking and carbon neutrality". Published original research papers as the sole first author in academic journals such as Nat Commun, J Am Chem Soc, P Natl Acad Sci, Green Chem, etc., with a total of 23 related articles and authorized patents.
2023.05-to date Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences，Professor，Doctoral supervisor
2018.09-2023.03 Nankai University/University of Copenhagen, Denmark，Postdoctoral
2015.09-2018.06 Nankai University/Washington State University in the United States，Ph.D.
2018 Tang Aoqing Chemistry Scholarship
2017 National Scholarship Council for Studying Abroad in the United States
1. Zhiyou Zong, Xinzhuo Liu, Zhuo Ye, Dingbin Liu* A double-switch pHLIP system enables selective enrichment and identification of circulating tumor-derived extracellular vesicles. P Natl Acad Sci, 2023, 120, e2214912120. (IF: 12.779，Q1)
2. Zhiyou Zong, Scott Mazurkewich, Caroline S. Pereira, Haohao Fu, Wensheng Cai, Xueguang Shao, Munir S. Skaf, Johan Larsbrink, Leila Lo Leggio* Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion. Nat Commun, 2022, 13(1): 1-10. (IF: 17.694，Q1)
3. Zhiyou Zong, Qiyu Li, Zhangyong Hong, Haohao Fu, Wensheng Cai*, Christophe Chipot, Huifeng Jiang, Dongyuan Zhang, Shulin Chen and Xueguang Shao*. Lysine mutation of the claw-arm-like loop accelerates catalysis by cellobiohydrolases. J Am Chem Soc, 2019, 141, 14451-14459. (IF: 16.383，Q1)
4. Zhiyou Zong, Ronglin He, Haohao Fu, Tanfeng Zhao, Shulin Chen, Xueguang Shao and Wensheng Cai* Pretreating cellulases with hydrophobins for improving bioconversion of cellulose: an experimental and computational study. Green Chem, 2016, 18: 6666-6674. (IF: 11.034, Q1)
5. Zhiyou Zong, Le Gao, Wensheng Cai, Liang Yu, Chao Cui, Shulin Chen and Dongyuan Zhang* Computer-assisted rational modifications to improve the thermostability of β-glucosidase from Penicillium piceum H16. BioEnerg Res, 2015, 8: 1384-1390. (IF: 3.852, Q2)
6. Zhiyou Zong, Lijuan Ma, Liang Yu, Dongyuan Zhang, Zhenhua Yang, Shulin Chen* Characterization of the interactions between polyethylene glycol and cellulase during the hydrolysis of lignocellulose. BioEnerg Res, 2015, 8: 270-278. (IF: 3.852, Q2)
7. Xuehui Liu, Zhiyou Zong, Xinzhuo Liu, Qiang Li, Ang Li, Chen Xu,* and Dingbin Liu* Stimuli-Mediated Specific Isolation of Exosomes from Blood Plasma for High-Throughput Profling of Cancer Biomarkers. Small Methods 2022, 6, 2101234. (IF: 15.367，Q1)
8. Xinzhuo Liu, Zhiyou Zong, Mindan Xing, Xuehui Liu, Jia Li, Dingbin Liu* pH-Mediated Clustering of Exosomes: Breaking Through the Size Limit of Exosome Analysis in Conventional Flow Cytometry. Nano Lett, 2021, 21, 8817？8823. (IF: 12.262，Q1)
9. Zhiyou Zong, Qiyu Li, Zhangyong Hong, Wensheng Cai* and Xueguang Shao*. Insight into the exo-exo synergy of Cel7A with Cel6A: an experimental and computational study. Research Square (preprint), https://doi.org/10.21203/rs.3.rs-298025/v1
10. Le Gao, Ronglin He, Zhiyou Zong, Dongyuan Zhang A β-glucosidase Hyperproducing Strain, Pencillium piceum: Novel Characterization of Lignocellulolytic Enzyme Systems and Its Application in Biomass Bioconversion: Microbial Production and Application. 2018, Fungal Cellulolytic Enzymes, DOI: 10.1007/978-981-13-0749-2_5.（学术专著）
As the person in charge, I have undertaken the Tianjin Synthetic Biotechnology Innovation Ability Enhancement Action Innovation Talent Project, National Key Research and Development Sub project, Leading Project Backbone of the Chinese Academy of Sciences, National Natural Science Foundation Youth Project, China Postdoctoral Science Foundation Project, and Central University Basic Research Project. As the main participant, I have participated in general projects of the National Natural Science Foundation.
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