Genetic tool development; Genome editing systems; High-throughput gene screening; Directed evolution; Mutant library construction; Synthetic biology; Chassis cell engineering; Functional gene mining
Education
Ph.D. in Microbiology, Northeast Agricultural University, 2015.09 –2019.06
B.Sc. in Biological Sciences (Science Experimental Class), Northeast Agricultural University, 2011.09 – 2015.06
Professional Experience
Associate Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 2025.09 – Present
Postdoctoral Research Fellow, Institute of Microbiology, Chinese Academy of Sciences, 2019.07 – 2025.06
(1) Xu, Tong; Li, Hao; Zhang, Shengjie; Wang, Jinhong; Hewage, Richard; Guo, Feng; Han, Yiran; Kondrasheva, Kseniya; Han. Jing*; Xiang, Hua*;论文Development of an endogenous Type I-E CRISPR-Cas-based gene editing tool for Halomonas nigrificans X339: Applications in enhancing poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production; Chemical Engineering Journal; 2025; 520:166147.
(2) Xu, Tong; Mitra, Ruchira; Tan, Dan; Li, Zhengjun; Zhou, Cheng; Chen, Tao; Xie, Zhengwei; Han, Jing; Utilization of gene manipulation system for advancing the biotechnological potential of halophiles: A review, Biotechnology Advances, 2024, 70: 108302
(3) Xu, Tong; Li, Hao; Zhang, Shengjie; Xue, Qiong; Hewage, Richard; Wang, Jinhong; Guo, Feng; Zhao, Dahe; Ai, Guomin; Kahramon, Davranov; Xiang, Hua; Han, Jing; Production of polyhydroxybutyrate from wheat straw hydrolysate using a low-salt requiring and alkaliphilic Halomonas nigrificans X339 under non-sterile open condition, Bioresource Technology, 2025, 132276
(4) Xu, Tong; Chen, Junyu; Mitra, Ruchira; Lin, Lin; Xie, Zhengwei; Chen, Guo-Qiang; Xiang, Hua; Han, Jing; Deficiency of exopolysaccharides and O-antigen makes Halomonas bluephagenesis self-flocculating and amenable to electrotransformation, Communications biology, 2022, 5(1): 623
(5) Xu, Tong; Chen, Huiwen; Li, Jincheng; Hong, Shan; Shao, Li; Zheng, Xiutao; Zou, Qiao; Wang, Yuting; Guo, Sijia; Jiang, Juquan; Implications for Cation Selectivity and Evolution by a Novel Cation Diffusion Facilitator Family Member From the Moderate Halophile Planococcus dechangensis, Frontiers in Microbiology, 2019, 10: 607
(6) Shao, Li; Xu, Tong; Zheng, Xiutao; Shao, Dandan; Zhang, Haitao; Chen, Huiwen; Zhang, Zhenglai; Yan, Mingxue; Abdel-Motaal, Heba; Jiang, Juquan; A novel three-TMH Na+/H+ antiporter and the functional role of its oligomerization, Journal of Molecular Biology, 2021, 433(2): 166730
(7) Mitra, Ruchira; Xu, Tong; Xiang, Hua; Han, Jing; Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory, Microbial Cell Factories, 2020, 19(1): 86
(8) Mitra, Ruchira; Xu, Tong; Chen, Guo-Qiang; Xiang, Hua; Han, Jing; An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis, Microbial Biotechnology, 2021, 15(5): 1446-1470.
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