Computational Biology; Low-Carbon Synthetic Biology; AI-Assisted Protein Engineering

2010.9 – 2014.7

B.E. in Biochemical Engineering, Beijing University of Chemical Technology, China

2014.9 – 2017.6

M.E. in Chemical Engineering and Technology, Beijing University of Chemical Technology, China

2017.9 – 2021.6

Ph.D. in Chemical Engineering and Technology, Beijing University of Chemical Technology, China

2019.12 – 2020.12

Visiting Student, Max Planck Institute for kohlenforschung, Germany

2022.1 – 2025.1

Assistant Researcher, School of Engineering, Westlake University, China

2025.5 – 2025.6

Visiting Scholar, School of Engineering, Westlake University, China

2025.9 – Present

Associate Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. China

1. Liu, J.^#, Zhang, H.^#, Xu, Y., Meng, H., & Zeng, A. P*. (2023). Turn air-captured CO2 with methanol into amino acid and pyruvate in an ATP/NAD (P) H-free chemoenzymatic system. Nature Communications, 2023, 14(1), 2772.

2. H Zhang, Y Li, J Nie, J Ren*, AP Zeng*. Structure-based dynamic analysis of the glycine cleavage system suggests key residues for control of a key reaction step[J]. Communications Biology, 2020, 3(1): 1-12.

3. Zheng, J., H Zhang., Xu, Q., Zeng, A., & Li, S.Z. MetaEnzyme: Meta Pan-Enzyme Learning for Task-Adaptive Redesign. 2024(1721–1730).Melbourne VIC, Australia.

4. L Cheng^#, H Zhang^#, Cui H, Cheng J, WY Wang; Wei B, Liu F,Liang H, XL Shen*, QP Yuan*. A novel α-L-rhamnosidase renders efficient and clean production of icaritin. Journal of Cleaner Production, 2022, 341, 130903.

5. L Cheng^#, H Zhang^#, H Cui, Mehdi D. Davari, WY Wang*, QP Yuan*. Efficient enzyme-catalyzed production of diosgenin: inspired by the biotransformation mechanisms of steroid saponins in Talaromyces stollii CLY-6[J]. Green Chemistry,2021,23, 5896-5910.

6. L Cheng, H Zhang, H Cui, WY Wang*, QP Yuan*. Efficient production of the anti-aging drug Cycloastragenol: insight from two Glycosidases by enzyme mining[J]. Applied Microbiology and Biotechnology, 2020, 104(23): 9991-10004.

7. L Cheng, H Zhang, H Liang, X Sun, X Shen, J Wang, WY Wang*, QP Yuan*. Enzymatic Bioconversion of Cycloastragenol-6-O-β-D-glucoside into Cycloastragenol by a Novel Recombinant β-Glucosidase from Phycicoccus sp. Soil748 [J]. Process Biochemistry, 2020, 90: 81-88.