My group focuses on the research of photobiocatalysis, the research topic covers molecular biology and simulation, enzyme engineering, biocatalysis, organic chemistry, chemocatalysis, chemical engineering and material chemistry. The specific research directions are:
-Research on the discovery and mechanism of photoenzymes
-Design and development of new methods and pathways via photobiocatalysis
-Research on the synthesis of functional molecules via photobiocatalysis
-Valorisatin of bio-resources via biocatalysis
-Design and development of green chemistry technology based on biocatalysis
Education
2012.9-2016.7 Ph.D. in Biotechnology, Delft University of Technology, Delft, the Netherlands
2009.9-2012.7 Master in Applied Chemistry, Hainan University, Haikou, China
2005.9-2009.7 Bachelor in Applied Chemistry, Hainan University, Haikou, China
Professional Experience
2020.11-now Principle Investigator, Full Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2019.9-2019.10 Principle Investigator, Associate Professor, Xi’an Jiaotong Univeristy, Xi’an, China
2015.10-2019.7 Postdoctoral researcher, Delft University of Technology, Delft, the Netherlands
1. Shen,Q.;Yan,J.;Han,Y.;Zhang,Z.*;Li,H.;Kong,D.;Shi,J.;Cui,C.*;Zhang,W.*,Peroxygenase Enabled Reductive Kinetic Resolution for the Enantioenrichment of Organoperoxides. Angew. Chem. Int. Ed.2024, e202401590.
2. Li,H.;Duan,P.*;Huang,Y.;Cui,C.;Hollmann,F.*;Ma,Y.;Wang,Y.;Zhang,J.;Liu,W.;Zhang*,W.,Vanadium-Containing Chloroperoxidase-Catalyzed Versatile Valorization of Phenols and Phenolic Acids. ACS Catalysis2024,14 (3),1733-1740.
3. Han,X.#;Chen,F.#;Li,H.;Ge,R.;Shen,Q.;Duan,P.*;Sheng,X.*;Zhang,W.*,Reaction engineering blocks ether cleavage for synthesizing chiral cyclic hemiacetals catalyzed by unspecific peroxygenase. Nature Communications2024,15 (1),1235.
4. Zhang,Y.;Zhou,X.;Cui,J.;Huang,Y.;Liu,X.;Zhang,Y.;Chen,B.;Zhang,W.*,Peroxygenase-catalysed selective and scalable synthesis of 25-hydroxy-grundmann's ketone and its derivatives. Molecular Catalysis2023,547,113389.
5. Li,Z.;Ge,R.;Tan,L.;Zhang,W.*;Zhang,Y.*,Photodecarboxylase Displayed on Microbial Cell-Surface for Enhanced Biocatalytic Performance. ChemCatChem2023, e202300494.
6. Li,H.;Zhang,Y.;Huang,Y.;Duan,P.;Ge,R.;Han,X.;Zhang,W.,A Simple Access to gamma- and epsilon-Keto Arenes via Enzymatic Divergent C horizontal line H Bond Oxyfunctionalization. Advanced Science2023,10 (34),e2304605.
7. Li,F.;Xia,A.*;Guo,X.;Huang,Y.;Zhu,X.;Zhang,W.*;Chen,R.;Liao,Q.,Photo-driven enzymatic decarboxylation of fatty acids for bio-aviation fuels production in a continuous microfluidic reactor. Renewable and Sustainable Energy Reviews2023,183,113507.
8. Huang,Y.;Li,H.;Zhang,P.;Zhang,Y.;Duan,P.;Zhang,W.*,H2O2-driven enzymatic oxyfunctionalization of tertiary C–H bonds. Chemical Communications2023,59 (60),9219-9222.
9. Gomez de Santos,P.;González-Benjumea,A.;Fernandez-Garcia,A.;Aranda,C.;Wu,Y.;But,A.;Molina-Espeja,P.;Maté,D. M.;Gonzalez-Perez,D.;Zhang,W.;Kiebist,J.;Scheibner,K.;Hofrichter,M.;Świderek,K.;Moliner,V.;Sanz-Aparicio,J.;Hollmann,F.;Gutiérrez,A.;Alcalde,M.,Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids. Angew. Chem. Int. Ed.2023,62 (9),e202217372.
10 Li,H.;Younes,S. H. H.;Chen,S.;Duan,P.*;Cui,C.;Wever,R.;Zhang,W.*;Hollmann,F.*,Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids. ACS Catalysis 2022,12 (8),4554-4559.
11. Wang,P.;Han,X.;Liu,X.*;Lin,R.;Chen,Y.;Sun,Z.*;Zhang,W.*,Synthesis of Enantioenriched Sulfoxides by an Oxidation-Reduction Enzymatic Cascade. Chemistry-A European Journal2022,28 (61),e202201997.
12. Shen,Q. Q.;Zhang,C.;Chen,L.;Huang,B. Q.;Yu,Y. S.;Zhang,Z. X.*;Zhang,W. Y.*,Characterization of Pt/g-C3N4-Catalyzed Methanol Oxidation to Drive Peroxygenase-Catalyzed Oxyfunctionalization of Hydrocarbons. ACS Sustainable Chemistry & Engineering2022,10,12156−12164.
13. Sang,X.;Tong,F.;Zeng,Z.*;Wu,M.;Yuan,B.;Sun,Z.;Sheng,X.;Qu,G.;Alcalde,M.;Hollmann,F.*;Zhang,W.*,A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines. Organic Letters 2022,24 (23),4252-4257.
14. Guo,X.;Xia,A.*;Li,F.;Huang,Y.;Zhu,X.;Zhang,W.*;Zhu,X.;Liao,Q.,Photoenzymatic decarboxylation to produce renewable hydrocarbon fuels: A comparison between whole-cell and broken-cell biocatalysts. Energy Conversion and Management2022,255,115311.
15. Chen,B.-S.;Zeng,Y.-Y.;Liu,L.;Chen,L.;Duan,P.;Luque,R.*;Ge,R.;Zhang,W.*,Advances in catalytic decarboxylation of bioderived fatty acids to diesel-range alkanes. Renewable and Sustainable Energy Reviews2022,158,112178.
16. Zhang,W.*;Li,H.;Younes,S. H. H.;Gomez de Santos,P.;Tieves,F.;Grogan,G.;Pabst,M.;Alcalde,M.;Whitwood,A. C.;Hollmann,F.*,Biocatalytic Aromaticity-Breaking Epoxidation of Naphthalene and Nucleophilic Ring-Opening Reactions. ACS Catalysis2021,11 (5),2644-2649.
17. Lin,R.;Deng,C.*;Zhang,W.*;Hollmann,F.;Murphy,J. D.*,Production of Bio-alkanes from Biomass and CO2. Trends in Biotechnology2021,39 (4),370-380.
18. Li,Y.;Yuan,B.;Sun,Z.;Zhang,W.*,C–H bond functionalization reactions enabled by photobiocatalytic cascades. Green Synthesis and Catalysis2021,2 (3),267-274.
19. Alagumalai,A.;Mahian,O.*;Hollmann,F.;Zhang,W.*,Environmentally benign solid catalysts for sustainable biodiesel production: A critical review. Sci Total Environ2021,768,144856.
20. Yuan,B.;Mahor,D.;Fei,Q.;Wever,R.;Alcalde,M.;Zhang,W.*;Hollmann,F.*,Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions. ACS Catalysis2020,10 (15),8277-8284.
21. Zhang,W.#;Lee,J.-H.#;Younes,S. H. H.;Tonin,F.;Hagedoorn,P.-L.;Pichler,H.;Baeg,Y.;Park,J.-B.*;Kourist,R.*;Hollmann,F.*,Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids. Nature Communications2020,11 (1),2258.
22. Zhang,W.#;Ma,M.#;Huijbers,M. M. E.#;Filonenko,G. A.;Pidko,E. A.;van Schie,M.;de Boer,S.;Burek,B. O.;Bloh,J. Z.;van Berkel,W. J. H.;Smith,W. A.;Hollmann,F.,Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids. Journal of the American Chemical Society2019,141 (7),3116-3120.
23. Zhang,W.;Fernández-Fueyo,E.;Ni,Y.;van Schie,M.;Gacs,J.;Renirie,R.;Wever,R.;Mutti,F. G.;Rother,D.;Alcalde,M.;Hollmann,F.*,Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations. Nature Catalysis2018,1 (1),55-62.
24. Huijbers,M. M. E.#;Zhang,W.#;Tonin,F.;Hollmann,F.,Light-Driven Enzymatic Decarboxylation of Fatty Acids. Angewandte Chemie International Edition2018,57 (41),13648-13651.
25. Dong,J.;Fernández-Fueyo,E.;Hollmann,F.;Paul,C. E.;Pesic,M.;Schmidt,S.;Wang,Y.;Younes,S.;Zhang,W.,Biocatalytic Oxidation Reactions: A Chemist's Perspective. Angewandte Chemie International Edition2018,57 (30),9238-9261.
Copyright ©, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China
Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
