We are interested in the mechanisms of LysR-type transcriptional regulators (LTTRs) and their applications in industrial biology. LTTRs compose the largest group of regulators in prokaryotes and participate in diverse cell functions, such as metabolism, cell division, nitrogen fixation and motility. Our works focus on their oligomerization, ligand reorganization, operator binding and interactions with RNA polymerase.
We also have interests in transporters. Though several models were proposed , the mechanisms of transporters still is a puzzle. We developed several methods to screen mutants with different phenotypes which will be helpful for understanding the transportation mechanisms. We also put efforts on crystallization of several transporters.
Education
2000-2004 Bachelor's Degree, school of life sciences, Nanjing Agricultural University
2004-2010 Master and Ph.D.Degree, department of microbiology, school of life sciences, Nanjing Agricultural University
Professional Experience
2007-2011 Visiting scholar, medical school, University of Pennsylvania.
2012-2021 Associate professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science
2021-present Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science
Copyright ©, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China
Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
