Name: Wang Meng
Title: Professor
E-mail: wangmeng@tib.cas.cn
The traditional paradigm of synthetic biology research has significant flaws such as manual operation, low throughput, and non-standardized data, which cannot meet the needs of the new era. Our group are interested in developing following solutions: 1) replacing manual experiments with robotic automation; 2) partially replacing human with software/AI algorithms for design and data analysis. We have initially developed a cutting-edge automated strain engineering and screening technology system and build the Tiangong-1 strain engineering facility.
2015-Present Principle Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2010-2015 Postdoctoral associate, University of Illinois at Urbana-Champaign, IL,USA
August 2005-December 2009 Doctor of Philosophy
Department of Chemistry
Syracuse University, Syracuse, NY
Thesis title: Characterizing Structure and Function of Thioesterase from Polyketide Synthase
Advisor: Professor Christopher N. Boddy (currently at University of Ottawa,
September 2001-July 2005 Bachelor of Science
Department of Chemistry
Zhejiang University, Hangzhou, Zhejiang,
Minor in Bioinformatics
Advisor: Professor Lin XianFu
Famous Craftsman of Science of Chinese Academy of Sciences
1. Lili Chang, Jin Wang, Meng Wang*, Yue Zhang*.(2025) Emerging strategies to develop novel genetically encoded biosensors. Trends Biotechnol, 2025, In press. https://doi.org/10.1016/j.tibtech.2025.04.014
2. Longqian Zhao,Shixin Li,Yi Yang,Linin Qi,Qinyuan Zhu,Yue Zhao,Hui Qi,Xiaoping Liao, Yue Zhang*,Meng Wang*. (2025)Biosensor-based dual-color droplet microfluidic platform for precise high-throughput screening of erythromycin hyperproducers. Biosens Bioelectron. 2025 Jun 15;278:117376. doi: 10.1016/j.bios.2025.117376. Epub 2025 Mar 13. PMID: 40090258.
3. Jiao Liu, Xiaojia Zhao, Haijiao Cheng, Yanmei Guo, Xiaomeng Ni, Lixian Wang, Guannan Sun, Xiao Wen, Jiuzhou Chen, Jin Wang, Jingjing An, Xuan Guo, Yu Wang*, Ping Zheng1*, Meng Wang*, Jibin Sun. (2025).Comprehensive screening of industrially relevant components at genome scale using a high-quality gene overexpression collection of Corynebacterium glutamicum,Trends Biotechnol. 2025 Jan;43(1):220-247. doi: 10.1016/j.tibtech.2024.09.020. Epub 2024 Oct 24. PMID: 39455323.
4. Jin Wang , Ning Xue, Wenjia Pan, Ran Tu , Shixin Li, Yue Zhang, Yufeng Mao, Ye Liu, Haijiao Cheng, Yanmei Guo, Wei Yuan, Xiaomeng Ni, Meng Wang*. (2023) Repurposing conformational changes in ANL superfamily enzymes to rapidly generate biosensors for organic and amino acids. Nat Commun.14(1):6680
5. Yang Liu, Haijiao Cheng, Haoni Li, Yingzhe Zhang, Meng Wang*. (2023) A programmable CRISPR/Cas9 toolkit improves lycopene production in Bacillus subtilis. Appl Environ Microbiol.
6. Yue Zhang*，Xuemei Zhang, Meng Wang*，(2023）Product-driven high-throughput screening of industrial filamentous actinomycetes，Trends Biotechnol, 41(9):1109-1112
7. Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang，Meng Wang *, Han Xiao *，Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast，(2022）Nat Commun. 13(1):7740
8. Siwei Li, Jingjing An, Yaqiu Li, Xiagu Zhu, Dongdong Zhao, Lixian Wang, Yonghui Sun, Yuanzhao Yang, Changhao Bi*, Xueli Zhang* & Meng Wang*, Automated high-throughput genome editing platform with an AI learning in situ prediction model. (2022), Nat Commun 13(1):7386
9. Ye Liu, Ruoyu Wang, Jiahui Liu, Hui Lu, Haoran Li, Yu Wang, Xiaomeng Ni, Junwei Li, Yanmei Guo, Hongwu Ma, Xiaoping Liao*, Meng Wang*，(2022) Base editor enables rational genome-scale functional screening for enhanced industrial phenotypes in Corynebacterium glutamicum，Sci Adv，8(35):eabq2157
10. Ran Tu, Yue Zhang, Erbing Hua, Likuan Bai, Huamei Huang, Kaiyue Yun, Meng Wang*,(2021) Droplet-based microfluidic platform for high-throughput screening of Streptomyces. Commun Biol, 31;4(1):647
11. Yu Wang*, Haijiao Cheng, Yang Liu, Ye Liu, Xiao Wen, Kun Zhang, Xiaomeng Ni, Ning Gao, Liwen Fan, Zhihui Zhang, Jiao Liu, Jiuzhou Chen, Lixian Wang, Yanmei Guo, Ping Zheng*, Meng Wang*, Jibin Sun and Yanhe Ma，(2021) In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nat Commun, 12(1):678.
12. Yu Wang*, Ye Liu, Ping Zheng, Jibin Sun and Meng Wang*,(2020) Microbial Base Editing: A Powerful Emerging Technology for Microbial Genome Engineering. Trends Biotechnol, 39(2):165-180
13. Xiaoting Lan, Wei Yuan, Meng Wang*, Han Xiao*. (2019). Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase. Biotechnol Bioeng 116(12):3301-3311
14. Han Xiao*, Yue Zhang#, Meng Wang*，（2018）Discovery and engineering of cytochrome P450s for terpenoid biosynthesis，Trends Biotechnol. pii: S0167-7799(18)30318-4
15. Yu W, Ye L, Jiao L, Yanmei G, Liwen F, Xiaomeng N, Xiaomei Z , Meng W*, Ping Z*, Jibin S*, Yanhe M，（2018）MACBETH: multiplex automated Corynebacterium glutamicum base editing method. Metabolic Engineering. May 47:200-210
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