Name: Wu Xin
Title: Professor
Tel: 022-24828794
E-mail: wuxin@tib.cas.cn
1. Utilizing the concepts and technologies of synthetic biology to conduct foundational innovation design of animal feed and human food, developing microbial protein sources and functional nutritional resource technologies for applications like single carbon feedstock and biomass utilization.
2. Based on human and animal nutritional metabolism and physiological functions, developing key technologies for biological synthesis and application of new microbial proteins, functional peptides, nucleotides, trace elements and other nutrients.
Xin Wu, born in 1979, member of CPC, Professor, Ph.D., Doctoral supervisor, researcher at National Synthetic Biology Innovation Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (TIB, CAS), PI of Biological Synthesis of Nutritional Resources Research Group. He obtained a Ph.D. from University of Chinese Academy of Sciences in 2010, and successively served as Assistant Professor, Associate Professor, and Professor at Institute of Subtropical Agriculture, CAS. He was a visiting scholar at French National Institute for Agricultural Research (INRA) and Erasmus University Medical Center in the Netherlands. Since 2021 he has been working as a Professor at TIB, CAS. He was selected into the “National High-level Personnel of Special Support Program”, “National Program for Support of Youth Scientific and Technological Innovation Leaders” and other programs.
His research focuses on microbial and nutritional resource development and their application in animal feed and food. He undertakes national key R&D projects, provincial and ministerial scientific and technological innovation projects. He has authorized 53 invention patents and published over 200 papers in journals like Bioresource Technology, Microbiome, Food & Function, Animal Nutrition, etc., with over 180 papers indexed in SCI. As the first three contributors, he has won 8 national, ministerial and provincial awards, including the National Natural Science Award Second Prize, the Chinese Academy of Sciences Science and Technology Advancement Award, the Chinese Agricultural Science and Technology Award, and the Provincial Invention Award First Prize. His main social positions include Council Member of Chinese Society of Animal Science, Secretary General of Trace Element and Food Chain Branch, etc.
1. Second Prize, National Natural Science Award (No.2 contributor), 2026
2. Second Prize, National Natural Science Award (No.3 contributor), 2016
3. First Prize, Hunan Provincial Technology Invention Award (No.2 contributor), 2017
4. Second Prize, CAS Science and Technology Promotion Development Award (No.2 contributor), 2018
5. First Prize, China Agricultural Science and Technology Award (No.3 contributor), 2015
6. First Prize for Innovation Team, China Agricultural Science and Technology Award (No.4 contributor), 2021
7. Excellent Graduate Supervisor Team, provincial level, 2018
8. Excellent Young Scientific and Technological Talent of Changsha, municipal level, 2019
1. Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao*, Xin Wu*. Cross-Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production. Advanced Science, 2026: e17703
2. Tiantian Zhou, Xinyi Chen, Yuehan Wang, Yuehan Wang, Xutao Zhang, Lingchao Miao, Rui Tian, Yumeng Li, Wai San Cheang*, Wu, Xin*. Amelioration of obesity-induced endothelial dysfunction by a synthetic ocean-derived peptide via regulating PPARα/γ pathway. Food Research International, 2026, 236: 119215
3. Changyu Pi, Jinyang Li, Fangting Jiang, Le Gao*, Xin Wu*. Closing Loop: Systems-Level Integration of Synthetic Consortia and Process Engineering for Lignocellulosic Microbial Lipid Biomanufacturing. Journal of Bioresources and Bioproducts, 2026: 100254
4. Le Gao*, Khoo Shing Ching, Zhaokun Zhang, Xin Wu*. Trends in Sustainable Production of Advanced Single-Cell Protein Manufacturing from Non-grain Feedstocks. Trends in Biotechnology, 2026, 44(1): 65–78
5. Yumeng Li, Tongtong Bao, Lumin Gao, Xutong Tian, Junyu Xue, Caike Jin, Shujin Wang, Xin Wu*. Aging triggers an intestinal energy crisis and HDL3 deficiency disrupting gut–liver axis homeostasis. Aging Cell, 2026, 25(3): e70445
6. Feng Yingying, Jialu Wang, Jinyang Li, Zhaokun Zhang, Yuying Wu, Gao Le*, Xin Wu*. Biosynthesis and nutritional evaluation of iron-enriched Aspergillus oryzae as a novel iron supplement. Food Research International, 2026, 227:118259
7. Chia Hau Lee, Bemgba Bevan Nyakuma, Tiantian Zhou, Junyu Xue, Theng Ho Cheong, Yumeng Li, Syie Luing Wong, Le Gao, Xin Wu*. Dietary geroprotective peptides: Structural determinants, AI-driven discovery, and synthetic biology production for healthy ageing. Food Research International, 2026, 236: 119189
8. Lumin Gao, Xudong Yang, Shufan Liu, Lu Liu, Xiaofan Ma, Shuguang Liu, Xin Wu*. One-carbon-derived bioactive peptides improve reproductive performance via regulating placental nutrient transport and offspring glycolipid metabolism. npj Science of Food, 2026, 10: 120.
9. Gao Le, Tiantian Zhou, Jie Yuan, Shouchang Zhang, Kai Hong, Zhaokun Zhang, Lee Chia Hau, Wai San Cheang, Chichun Zhou*, Wu Xin*. AI-Powered De Novo Architecturing of Marine-Mimetic Antioxidant Peptides in Yeast Synbio Factories. Chemical Engineering Journal, 2025, 169604
10. Le Gao, Jie Yuan, Kai Hong, Xin Wu*. Advancing Pichia pastoris: A Next-Generation Platform for Sustainable Biomanufacturing. Biotechnology advances, 2025, 82(6):108593
11. Changyu Pi, Jinyang Li, Tongtong Bao, Le Gao*, Xin Wu*. Integrated Base Editing and Microfluidics Boost Microbial Lipid Production from Lignin. Bioresource Technology, 2025: 133441
12. Gao L, Meng J, Wuling Dai, Zhaokun Zhang, Haofan Dong, Qianqian Yuan, Wuyuan Zhang, Liu SG, Wu Xin*. Deciphering cell wall sensors enabling the construction of robust P. pastoris for single-cell protein production. Biotechnology for Biofuels and Bioproducts,2023 DOI: 10.1186/s13068-023-02428-7
13. Meng Jiao, Liu Shufan, Gao Le, Hong Kai, Liu Shuguang, Wu Xin*. Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale. Microbial Cell Factories, 2023, 22: 198
14. Le Gao, Zhuohang Yu, Shengjie Wang, Yuejie Hou, Shouchang Zhang, Chichun Zhou*, Wu Xin*. A new paradigm in lignocellulolytic enzyme cocktail optimization: free from expert-level prior knowledge and experimental datasets. Bioresource Technology, 2023, (388): 29758
15. Yingying Feng, Teketay Wassie, Renyou Gan*, Xin Wu*. Structural Characteristics and Immunomodulatory Effects of Sulfated Polysaccharides Derived from Marine Algae. Critical Reviews in Food Science and Nutrition, 2023, 63: 7180–7196
16. Le Gao, Yi Jiang, Kai Hong, Xiaoyi Chen*, Wu, Xin*. Glycosylation of cellulase: A novel strategy for improving cellulase. Critical reviews in biotechnology, 2023, Doi:10.1080/07388551.2022.2144117
17. Shujin Wang*, Wei Fu, Xueya Zhao, Xiaojiao Chang, Hujun Liu, Lin Zhou, Jian Li, Rui Cheng, Xin Wu*, Xi Li*, Changpo Sun*. Mycotoxin disturbs the reproductive-immune axis: the role of gut microbial metabolites. Microbiome, 2022, 10:234
18. Teketay Wassie, Xinyi Duan, Chunyan Xie, Ruxia Wang, Xin Wu*. Dietary Enteromorpha polysaccharide-Zn supplementation regulates amino acid and fatty acid metabolism by improving the antioxidant activity in chicken. Journal of Animal Science and Biotechnology, 2022, 13: 18
19. Lumin Gao, Gangyi Liu, Hongling Wang, Wassie Teketay, Xin Wu*. Maternal pyrimidine nucleosides supplementation regulates fatty acid, amino acid and glucose metabolism of offspring. Animal Nutrition, 2022, 11: 309-321
20. Chunyan Xie, Yumei Zhang, Kaimin Niu, Xiaoxiao Liang, Haihua Wang, Junwei Shan, Xin Wu*. Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets. Animal Nutrition, 2021, 7(3): 641-649
21. Yin Jie, Yuying Li, Hui Han, Shuai Chen, Jing Gao, Gang Liu, Xin Wu*, Jinping Deng, Xingguo Huang, Rejun Fang, Tiejun Li*, Russel J. Reiter, Guoqiang Zhu, Wenkai Ren*, Yulong Yin. Melatonin improves lipid metabolism by reprograming gut microbiota and microbiota-derived acetic acid. Journal of Pineal Research, 2018, 65: e12524
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