His main research interests are the biosynthesis of vitamin B12, the use of metabolic engineering to engineer bacteria to achieve high chemical yields, and the development of synthetic biology-enabling tools such as CRISPR-dependent gene editing. He was selected as a member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences in 2020 and has successively presided over projects such as the National Natural Science Youth Foundation of China and the National Key R&D Program, and has published more than 20 articles in Nature Communications, Microbial Cell Factories, and other journals in recent years, and obtained 3 authorized patents.

2020-present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Associate Professor.

2018-2020, Assistant Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences.

2013-2018, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Ph.D., Microbiology;  

2009-2012, Zhengzhou University, M.S., Biophysics;                 

2005-2009, Binzhou University, B.S., Biological Sciences

Tianjin Science and Technology Progress Award, First Prize, 2020

China Light Industry Federation Science and Technology Progress Award, Second Prize, 2020

1. Jing Zhao#, Huan Fang#, et al. Expanding application of CRISPR-Cas9 system in microorganisms. Synthetic and Systems Biotechnology 5 (2020) 269–276

2. Fang, H., Li, D., Kang, J. et al. Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12. Nature Communications 9, 4917 (2018).

3. Dong Li#, Huan Fang#. et al. Bioprocess and Biosystems Engineering (2020) 43:1735–1745

4. Pingtao Jiang#, Huan Fang #. et al. Microbial Cell Factories: 2020, 19:118.

5. Fang H, Kang J, Zhang D: Microbial production of vitamin B12: a review and future perspectives. Microbial Cell Factories 2017, 16:15.

6. Fang H, Dong H, Cai T, Zheng P, Li H, Zhang D, Sun J: In Vitro Optimization of Enzymes Involved in Precorrin-2 Synthesis Using Response Surface Methodology. PLOS ONE 2016, 11:e0151149.

Synthesis Mechanism of adenosylcobinamidephosphate in Sinorhizobium meliloti, PI, 2020-01--2022-12

Biochemical Reaction Design of New Molecules and Reconstruction of Core Life Pathways, 2019-07--2024-06

Project of Youth Innovation Promotion Association of Chinese Academy of Sciences, Principal Investigator, 2020-01--2023-12

Construction and Application of Next-Generation Network Models for Biomanufacturing Strains of Important Industrial Chemicals, PI, 2021-07--2024-06