(1) Development of scalable microbial protein synthesis systems and green production processes for low-value raw materials, including the development of functional feed/food protein, and the research and industrialization of key application technologies.
(2) Key technologies for the biological synthesis of functional peptides, functional proteins, antioxidant products, and other nutritional substances, and the research and industrialization of key application technologies.
Le Gao, Associate Professor, Ph.D., graduated from Shandong University National Key Laboratory of Microbial Technology, currently serves as Associate Professor at Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of Sciences (CAS). Her research focuses on exploring the highly efficient conversion mechanisms of methanol and agricultural residues like straw by yeast and filamentous fungi. She has constructed a functional component library and regulatory element library of low-value feedstock metabolism through omics data mining. This involves omics data mining and the construction of functional component and regulatory element libraries for the metabolism of low-value feedstocks. Her innovative work includes the development of unsupervised machine learning models that accurately solve the optimal enzyme system composition based on lignocellulosic structural characteristics. This breakthrough significantly contributes to the production of functional nutrients, such as functional proteins/peptides, enzymes, and natural products, from low-value feedstocks. Her innovative work includes the development of unsupervised machine learning models that accurately solve the optimal enzyme system composition based on lignocellulosic structural characteristics. This breakthrough significantly contributes to the production of functional nutrients, such as functional proteins/peptides, enzymes, and natural products, from low-value feedstocks. She has authorized 23 national invention patents, among which 8 were licensed or transformed, and has published over 30 papers as first/corresponding author in journals like Bioresour. Technol., Crit Rev Biotechnol., Biotechnol. Biofules, J.B.C., etc., and participated in publishing 1 English monograph. She has undertaken over 10 projects including National Key R&D Program, NSFC, 863 Program, Tianjin Science and Technology Program, and cooperation projects with Jilin Province.
Outstanding Award, 8th China Innovation Contest, Biological Manufacturing Technology
1. Le Gao, Zhuohang Yu, Shengjie Wang, Yuejie Hou, Shouchang Zhang, Chichun Zhou*, Xin Wu*. A new paradigm in lignocellulolytic enzyme cocktail optimization: Free from expert-level prior knowledge and experimental datasets. Bioresource Technology. 2023, 388,12975.
2. Le Gao, Yi Jiang, Kai Hong, Xiaoyi Chen*, Xin Wu*. Glycosylation of cellulase: a novel strategy for improving cellulase. Critical Reviews in Biotechnology. 2022, 1:11.
3. Le Gao, Jiao Meng, Wuling Dai, Zhaokun Zhang, Haofan Dong, Qianqian Yuan, Wuyuan Zhang, Shuguang Liu, Xin Wu*. Deciphering cell wall sensors enabling the construction of robust P. pastoris for single-cell protein production. 2023. DOI: 10.1186/s13068-023-02428-7
4. Le Gao, Qi Guo, Ruinan Xu, Haofan Dong, Chichun Zhou, Zhuohang Yu, Zhaokun Zhang, LixianWang; Xiaoyi Chen*, Xin Wu*. Loop-optimization of Trichoderma reesei endoglucanases for balancing the activity–stability trade-off through cross-strategy between machine learning and the B-factor analysis. GCB bioenergy. 2022,0:1-15.
5. Le Gao, Dongyuan Zhang, Feng Gao, Zhiyong Liu, Yuyong Hou, Demao Li, Shulin Chen*. Hydroxyl radical-aided thermal pretreatment of algal biomass for enhanced biodegradability. Biotechnology for biofuels. 2015,8:194.
6. Feng Gao#, Le Gao#, DongYuan Zhang, Nehao Ye, Shulin Chen, Demao Li*. Enhanced hydrolysis of Macrocystis pyrifera by integrated hydroxyl radicals and hot water pretreatment. Bioresource Technology. 2015, 179:490–496.
7. Le Gao, Feng Gao, Dongyuan Zhang, Can Zhang, Gaihong Wu, Shulin Chen*. Purification and characterization of a new β-glucosidase from Penicillium piceum and its application in enzymatic degradation of delignified corn stover. Bioresource Technology. 2013, 147:658-661.
8. Le Gao, Feng Gao, Lushan Wang, CunliangGeng, Jian Zhao, Yinbo Qu*. N-glycoform Diversity of CBHIs and the new features of a non-enzymatic glycoform from Penicillium decumbens. J. Biol. Chem. 2012, 287:15906-15915.
9. Le Gao, Fenghui Wang, Feng Gao, Lushan Wang, Jian Zhao, Yinbo Qu*. Purification and characterization of a novel cellobiohydrolase (PdCel6A) from Penicillium decumbens JU-A10 for bioethanol production. Bioresource Technology. 2011. 102, 8339-8342.
1. National Key R&D Program “Green Manufacturing of Livestock and Poultry Green Anti-inflammatory and Disease Resistance Efficacy Products”, 2022YFC2105000, PI
2. Key Program of Governmental International Science and Technology Innovation Cooperation, National Key R&D Program, “Development of High Value-added Products from Lignocellulose Based on Process Biomimesis”, 2018YFE0107100, PI
3. National Natural Science Foundation of China, “Mechanism of biomass degradation involving novel reducing factors-dehydrogenases”, 21460260, PI
4. 863 Program, “Key Technologies for Integrated High Efficiency Whole Component Utilization of Non-grain Cassava”, 2014AA021906, PI
5. CAS Technology Achievements Transfer and Transformation Project in Henan Province, “Preparation Process of Amino Acid Complex Salts and Protein Complex Salts”, 2023101, PI
6. Jilin Province and CAS Cooperation Project for High-tech Industrialization, “Industrial Application and Extension of Alcohol-specific Enzymes in Starch Ethanol”, 2022SYHZ0015, PI
7. Jilin Province and CAS Cooperation Project for High-tech Industrialization, “Application of Cellulase in Starch Ethanol and Extension of Cellulase”, 2019SYHZ0012, PI
8. Tianjin Science and Technology Support Program, “Key Technologies for Whole Component Utilization of Corn Stover”, 18ZXYENC00150, PI
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