Design and construction of synthetic pathways, followed by pathway.
Optimized synthetic pathways through coordinated gene expression, cofactor engineering and metabolic evolution.
Optimization of cell physiology through adaptive evolution, followed by characterization of their genetic mechanisms.
2006/9–2009/12， Doctor's Dgree, College of Life Science, Nankai University. Major: Microbiology.
2002-09--2005-07 Bachelor's degree, College of Life Science, Northeast A&F University. Major: Botany.
2016/10- present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences。Associate professor.
1. Meng Zhang+, QingYan Li*, Feiyu Fan, Fuping Lu, XueLi Zhang*. Combinatorial metabolic engineering and tolerance evolution of Yarrowia lipolytica for improved γ-decalactone synthesis, Process Biochem. 2023, 132:248-254
2. Meng Zhang+, Zhongkuo Gong+, Jinlei Tang， Fuping Lu, QingYan Li* and XueLi Zhang*. Improving astaxanthin production in Escherichia coli by co-utilizing CrtZ enzymes with different substrate preference，Microb Cell Fact. 2022, 21:71
3. Jie Wang, Dongdong Zhao, Ju Li, Muzi Hu, Xiuqing Xin, Marcus A Price, Qingyan Li, Li Liu, Siwei Li, Susan J Rosser, Chunzhi Zhang, Changhao Bi*, Xueli Zhang*. Helicase-AID:A novel molecular device for base editing at random genomic loci. Metab Eng. 2021,67: 396-402
4. Zhongkuo Gong+; Honglei Wang*; Jinlei Tang; Qingyan Li*; Xueli Zhang*; Coordinated Expression of Astaxanthin Biosynthesis Genes for Improved Astaxanthin Production in Escherichia coli, J. A gric. Food Chem. 2020, 68(50): 14917-14927
5. Tao Wu, Siwei Li, Lijun Ye, Dongdong Zhao, Feiyu Fan, Qinyan Li, Bolin Zhang, Changhao Bi*, Xueli Zhang*. Engineering an Artificial Membrane Vesicle Trafficking System (AMVTS) for the Excretion of β-Carotene in Escherichia coli. ACS Synth Biol. 2019. 17;8(5):1037-1046
6. Jinying Guo, Kunle Hu, Changhao Bi, Qingyan Li*, Xueli Zhang*. Construction of an alternative glycerol-utilization pathway for improved β-carotene production in Escherichia coli. J Ind Microbiol Biotechnol. 2018.45(8):697-705
7. Qingyan Li, Feiyu Fan, Xiang Gao, Chen Yang, Changhao Bi, Jinlei Tang, Tao Liu, Xueli Zhang*. Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli. Metab Eng. 2017. 44:13-21
8. Tao Wu, Lijun Ye, Dongdong Zhao, Siwei Li, Qinyan Li, Changhao Bi*, Xueli Zhang*. Membrane engineering - A novel strategy to enhance the production and accumulation of β-carotene in Escherichia coli. Metab Eng. 2017, 43:85-91.
9. Lijun Ye, Ping He, Qinyan Li, Xueli Zhang*, Changhao Bi*. Type IIs restriction based combinatory modulation technique for metabolic pathway optimization. Microb Cell Fact. 2017, 16:47.
10. Lijun Ye, Chunzhi Zhang, Changhao Bi, Qinyan Li*, Xueli Zhang*. Combinatory Optimization of Chromosomal Integrated Mevalonate Pathway for β-carotene Production in Escherichia coli. Microb Cell Fact. 2016, 15:202.
11. Tao Sun, Liangtian Miao, Qinyan Li*, Guanping Dai, Fuping Lu, Tao Liu, Xueli Zhang*, Yanhe Ma. Production of lycopene by metabolically-engineered Escherichia coli. Biotechnol Lett, 2014, 36(7): 1515–1522.
12. Jing Zhao, Qingyan Li, Tao Sun, Xinna Zhu, Hongtao Xu, Jinlei Tang,Xueli Zhang*, Yanhe Ma. Engineering central metabolic modules of Escherichia coli for improving β-carotene production. Metab Eng. 2013, 17: 42-50.（并列一作）
1. The National Key R&D Program of China (No.2019YFA0905704,2020-2024), “Production Enhancement and Industrial Application of Natural Product Cell Factories”.720 000 RMB,Sub-project leader.
2. The National Key R&D Program of China (No.2019YFA0905301, 2020-2024),“Design and validation of steroid hormone biosynthesis pathways”.1354 000 RMB,Sub-project leader.
3. National Natural Science Foundation of China (No.31770059, 2018-2021 ), “Artificial regulation of the key precursor supplies of the MEP pathway for terpenoid compounds”.600 000 RMB. Project leader.
4. National Natural Science Foundation of China (No.31770105, 2018-2021 ),“Regulation of carotenoids accumulation in Escherichia coli”. 600 000 RMB. Project participant.
5. Zhejiang Zhenyuan Pharmaceutical Co.,Ltd.“Production Technology of Astaxanthin from Fermentation”.2017/12- 2021/12，3000 000 RMB. Project participant.
6. The Tianjin Commission of Science and Technology as key technologies R&D projects. (No.15JCYBJC49400,2015/04-2017/03)，“Research on MEP Metabolic Pathways and Construction of Terpene Cell Factories in Escherichia coli” 100 000 RMB.Project leader.
7. Tianjin Key Technology R&D program of Tianjin Municipal Science and Technology Commission (No.12ZCZDSY14700,2012/10-2014/09)，“Production of Lycopene by Recombinant Escherichia coli from Fermentation”.750 000 RMB.Project participant.
8. National Natural Science Foundation of China (No.31100047,2012/01-2014/12), “Study on the directed evolution and catalytic mechanism of phosphoenolpyruvate carboxylation kinase”.220 000, Project leader.
9. The “863” Program of China (No. 2011AA02A203,2011-2015)，“Biochemical combination synthesis technology of polybutylene succinate”.1663 000 RMB.Sub-project leader.
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