The development and application of genome editing technology and synthetic biology technology, Specialize in: Genome editing technology in mammalian cells, gene therapy research, the development of delivery vector for genome editing tools.

1. Education

2009-09-2014-06, Doctor of Philosophy in Biochemistry and molecular biology, Nankai University

2005-09-2009-06, Bachelor of Science in Life sciences, Tangshan Normal University 

2. Professional Experience

2014.07-2022.7, Research Associate, Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences

2022.7-present, Associate Investigator, Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences

(1) Li Siwei; An Jingjing; Li Yaqiu; Zhu Xiagu; Zhao Dongdong; Wang Lixian; Sun Yonghui; Yang Yuanzhao; Bi Changhao; Zhang Xueli; Wang Meng ; Automated high-throughput genome editing platform with an AI learning in situ prediction model, Nature Communications, 2022, 13(1)

(2). Zhao, Dongdong; Li, Ju; Li, Siwei; Xin, Xiuqing; Hu, Muzi; Price, Marcus A.; Rosser, Susan J.; Bi, Changhao; Zhang, Xueli ; Glycosylase base editors enable C-to-A and C-to-G base changes, Nature Biotechnology, 2021, 39(1): 35-40

(3) Wu, Tao; Li, Siwei; Ye, Lijun; Zhao, Dongdong; Fan, Feiyu; Li, Qinyan; Zhang, Bolin; Bi,Changhao; Zhang, Xueli ; Engineering an Artificial Membrane Vesicle Trafficking System (AMVTS) for the Excretion of beta-Carotene in Escherichia coil, ACS Synthetic Biology, 2019, 8(5): 1037-1046

(4)Xie Qianwen; Li Siwei; Zhao Dongdong; Ye Lijun; Li Qingyan; Zhang Xueli; Zhu Li; Bi Chang hao ; Manipulating the position of DNA expression cassettes using location tags fused to dCas9 (Cas9-Lag) to improve metabolic pathway efficiency, Microbial Cell Factories, 2020, 19(1)

(5) Wu Tao; Li Siwei; Zhang Bolin; Bi Changhao; Zhang Xueli ; Engineering Saccharomyces cerevisiae for the production of the valuable monoterpene ester geranyl acetate, Microbial Cell Factories, 2018, 17(1): 85