Associate Professor/Senior Engineer
Lin Yuping

Title:Lin Yuping

E-mail:lin_yp@tib.cas.cn

Research Interest

Dedicated to researches on synthetic microbial consortium, yeast genome engineering and omics, investigating the bottlenecks in microbial protein synthesis as well as the interactions between synthetic microbial communities, thus enhancing the ability of individual strain and the synergy of synthetic microbial consortium to produce microbial proteins.

Education & Professional Experience

Education

Ph.D., 2005.09 – 2010.06, Biochemistry and Molecular Biology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

M.S., 2002.09 – 2005.06, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou, China

B.S., 1997.09 – 2001.06, Pomology of Horticulture, Shandong Agricultural University, Tai'an, China

Work Experience

2021.04 – Present, Tianjin Institute of Industrial Biotechnology, CAS, Project Manager/Associate Professor

2015.10 – 2021.03, Qinhong Wang group, Tianjin Institute of Industrial Biotechnology, CAS, Associate Professor

2019.08 – 2020.02, Chalmers University of Technology in Sweden, Visiting Scholar

2015.07 – 2015.09, Tianjin Institute of Industrial Biotechnology, CAS

2011.04 – 2015.06, University of California, Berkeley, Postdoc

2010.08 – 2011.03, Chalmers University of Technology in Sweden, Research associate

2002.03 – 2002.08, Laiwu Forestry Bureau of Shandong Province, Engineer assistant

Honors and Awards

2017, Core member of Industrial Synthetic Biological Innovation Team, Innovation team in key areas of the Tianjin Innovation Talent Promotion Program

Selected Publications

Published 28 SCI papers in journals of Microbiology Spectrum, Biotechnology for Biofuels and Bioproducts, ACS Synthetic Biology, Molecular & Cellular Proteomics, eLife, etc., 5 Chinese Core Journals papers, and applied 6 patents of China including authorized 3 patents.

(#first author, *corresponding author)

1. Guokun Wang*, Yuping Lin, Qinhong Wang, Xin Wu*, Yulong Yin*, Yanhe Ma*. Microbial protein manufacturing: The developing trend and challenge. Science Bulletin. 2023;68(21):2779-2789.

2. Huiling Yuan, Ying Zhou, Yuping Lin, Ran Tu, Yufeng Guo, Yuanyuan Zhang, Qinhong Wang*. Microfluidic screening and genomic mutation identification for enhancing cellulase production in Pichia pastoris. Biotechnology for Biofuels and Bioproducts. 2022;15(1):50.

3. Zhen Wang, Yuping Lin#, Zongjie Dai, Qinhong Wang*. Modulating DNA repair pathways to diversify genomic alterations in Saccharomyces cerevisiae. Microbiology Spectrum. 2022;e0232621.

4. Yanfang Liu, Yuping Lin#*, Yufeng Guo, Fengli Wu, Yuanyuan Zhang, Xianni Qi, Zhen Wang, Qinhong Wang*. Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae. Biotechnology for Biofuels. 2021;14(1):155.

5. Zhen Wang#, Qi Qi#, Yuping Lin*, Yufeng Guo, Yanfang Liu, Qinhong Wang*. QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast. Biotechnology for Biofuels. 2019;12:59.

Project

1. National Key R&D Plan Project, Frontier Technologies and New Product Innovation in Feed Protein Bioengineering Manufacturing, 2021.11-2024.11, ongoing,Task Leader

2. Chinese Academy of Sciences Strategic Leading Science and Technology Project (Class A), Black Land Protection and Utilization Technology Innovation, 2021-2026, ongoing, Subtask Leader

3. Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project, 2021.03-2024.02, ongoing, Project Manager

4. National Science Foundation of China, No. 31700077, Exploring Effects and Mechanisms of DNA Repair Proteins Mre11 and Sae2 on Genome Editing in Saccharomyces cerevisiae, 2018.01-2020.12, Completed, Leader

5. Science and Technology Foundation for Selected Overseas Chinese Scholar of Tianjin, No. 2016003, Key Technologies and Application of Genome Editing in Breeding High Performance Saccharomyces cerevisiae, 2016, Completed, Leader

6. National Science Foundation of Tianjin, No. 16JCYBJC43100, Toward a Science of Improving Diversified Mutations by Genome Editing in Saccharomyces cerevisiae, 2016.10-2019.09, Completed, Leader

7. National Science Foundation of Tianjin, No. 31470214, Towards a Science of Multiple Stress Tolerance Improvement in Saccharomyces cerevisiae by Multiplex Genome Editing, 2015.01-2018.12, Completed, participant

8. National Science Foundation of Tianjin, No. 31270098, Study on Glucose Repression and Its Regulatory Mechanism in Natural Xylose-utilizing yeast Candida maltosa, 2013.01-2016.12, Completed, participant