1/Rational Design of Enzymes: Employing methods such as molecular dynamics, quantum chemistry, and machine learning to rationally design and modify enzymes in terms of their catalytic activity, structural stability, substrate specificity, and cofactor dependency.
2/Design of Biological Probes: By designing and modifying the substrate binding pocket and the elastic network of transcriptional regulatory factors, develop biological probes specific for certain compounds.
3/Design of Biosynthetic Pathways: Utilizing the retrosynthetic approach from organic synthesis combined with deep learning algorithms to construct entirely new biosynthetic pathways.
1998-2002, College of Chemistry, Nankai University, Chemistry, Bachelor’s
2002-2005, State Key Laboratory of Elemento-Organic Chemistry, Pesticide Science, Master’s
2005-2011, State Key Laboratory of Elemento-Organic Chemistry, Pesticide Science, Ph.D.
2012-2015, College of Life Sciences, Nankai University, Drug Design, Postdoctoral
2015 to present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Enzyme Design
Copyright ©, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China
Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
