Dr. Liu's research interest includes automated high-throughput editing and screening of industrial strains. She has developed advanced gene editing and regulation technologies for industrial microorganisms such as Bacillus subtilis. Establishing an automated high-throughput synthetic biology biofoundry for Bacillus subtilis engineering strains is ongoing. She is also interested in the biosynthesis of secondary metabolites from microorganisms, and metabolic engineering by genetic and combinatorial strategies.

2006-9 to 2010-6, BSc, Faculty of Forestry, Southwest Forestry University, China

2011-9 to 2016-6, Ph.D., Key Laboratory of Marine Drugs, Ministry of Education School of Medicine and Pharmacy, Ocean University of China, China

2016-7 to 2023-9, Assistant professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences: Tianjin, CN

2023-9 to present, Associate Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences: Tianjin, CN

2016, The second prize of Outstanding Scientific and Technological Innovation Achievements of graduate students in Shandong Province

2016, The 17th Excellent Doctoral Dissertation Award, Ocean University of China

2016, Excellent Graduates in Ocean University of China

1. Wang, Y. ^#*, Cheng, H. ^#, Liu, Y. #, Liu, Y., Wen, X., Zhang, K., Ni, X., Gao, N., Fan, L., Zhang, Z., Liu, J., Chen, J., Wang, L., Guo, Y., Zheng, P.^*, Wang, M.^*, Sun, J., & Ma, Y. (2021). In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nature communications, 12(1), 678.

2. Liu, Y., Cheng, H., Li, H., Zhang, Y., &Wang, M.^* (2023). A Programmable CRISPR/Cas9 Toolkit Improves Lycopene Production in Bacillus subtilis. Applied and environmental microbiology, 89(6), e0023023.

3. Liu, Y., Liu, Y., & Wang, M.^* (2017). Design, Optimization and Application of Small Molecule Biosensor in Metabolic Engineering. Frontiers in microbiology, 8, 2012.

4. Liu, Y. ^#, Liu, Y. #, Zheng, P., Wang, Y., & Wang, M.^* (2023). Cytosine Base Editing in Bacteria. Methods in molecular biology, 2606, 219-231.

5. Xiao, F., Dong, S., Liu, Y., Feng, Y., Li, H., Yun, C. H., Cui, Q., & Li, W. ^* (2020). Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. Journal of the American Chemical Society, 142(37), 16031-16038.

6. Liu, Y., Qin, W., Liu, Q., Zhang, J., Li, H., Xu, S., Ren, P., Tian, L., & Li, W. (2016). Genome-wide identification and characterization of macrolide glycosyltransferases from a marine-derived Bacillus strain and their phylogenetic distribution. Environmental microbiology, 18(12), 4770-4781.

7. Qin, W.^#, Liu, Y.#, Ren, P., Zhang, J., Li, H., Tian, L., & Li, W. (2014). Uncovering a glycosyltransferase provides insights into the glycosylation step during macrolactin and bacillaene biosynthesis. Chembiochem, 15(18), 2747-2753.

8. Liu, Y., Zheng, H., Zhan, G., Qin, W., Tian, L., & Li, W. (2014). Establishment of an efficient transformation protocol and its application in marine-derived Bacillus strain. Science China. Life sciences, 57(6), 627–635.

9. Yu, S. ^#, Price, M. A. ^#, Wang, Y., Liu, Y., Guo, Y., Ni, X., Rosser, S. J., Bi, C., & Wang, M. (2020). CRISPR-dCas9 Mediated Cytosine Deaminase Base Editing in Bacillus subtilis. ACS synthetic biology, 9(7), 1781–1789.

10. Liu, Q. ^#, Ren, P. ^#, Liu, Y., Qin, W., Li, H., & Li, W. (2018). Exploration of the Glycosyltransferase BmmGT1 from a Marine-Derived Bacillus Strain as a Potential Enzyme Tool for Compound Glycol-Diversification. Journal of microbiology and biotechnology, 28(6), 931–937. 

National Natural Science Foundation of China, Research on the fine-tuning of multi-gene expression in the hyperproduction of lycopene in Bacillus subtilis, 2022.01-2024.12

National Key R&D Program of China, Ministry of Science and Technology of PR China, High-throughput Raman-activated cell sorting instrument, 2023.05-2027.04

The Key Project of Chinese Academy of Sciences, Construction of a high-throughput automation technology platform and its application in natural product mining and screening, 2016.08-2020.12