My research focuses on in vitro synthetic biology, including the design of multi-enzymatic reaction pathways, the construction of in vitro synthetic enzymatic biosystems, and optimization of the systems for high-efficient production of value-added chemicals.
1. Education
2015 Doctor of Philosophy, The Hong Kong Polytechnic University
2006 Bachelor of Science in Applied Biology with Biotechnology, The Hong Kong Polytechnic University
2. Professional Experience
2022-Present Associate Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
2016-2022 Research Associate, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
2015-2016 Postdoctoral Fellow, The Hong Kong Polytechnic University
1. Y. Qin, Q. Li, L. Fan, X. Ning, X. Wei*, C. You*, Biomanufacturing by In Vitro Biotransformation (ivBT) Using Purified Cascade Multi-enzymes, In: Y. Lu, M.C. Jewett (eds) Cell-free Production. Advances in Biochemical Engineering/Biotechnology, Springer, 2023, 186: 1-28.
2. G. Li#, X. Wei#, R. Wu, W. Zhou, Y. Li, Z. Zhu, C. You*, Stoichiometric conversion of maltose for biomanufacturing by in vitro synthetic enzymatic biosystems, BioDesign Research, 2022, Article ID 9806749.
3. C. Hu, X. Wei*, Y. Song*, A thermophilic phosphatase from Methanothermobacter marburgensis and its application to in vitro biosynthesis, Enzyme and Microbial Technology, 2022, 159: 110067.
4. X. Wei, Q. Li, C. Hu, C. You*, An ATP-free in vitro synthetic enzymatic biosystem facilitating one-pot stoichiometric conversion of starch to mannitol, Applied Microbiology and Biotechnology, 2021, 105 (5): 1913-1924.
5. T. Cai#, H. Sun#, J. Qiao#, L. Zhu#, F. Zhang, J. Zhang, Z. Tang, X. Wei, J. Yang, Q. Yuan, W. Wang, X. Yang, H. Chu, Q. Wang, C. You, H. Ma, Y. Sun, Y. Li, C. Li, H. Jiang, Q. Wang, Y. Ma*, Cell-free chemoenzymatic starch synthesis from carbon dioxide, Science, 2021, 373(6562): 1523-1527.
6. X. Wei, D. Meng, C. You*, Chapter 8 In vitro metabolic engineering: current status and recent progress, In: L. Liu, G.C. Du, Y.F. Liu (eds) Systems and Synthetic Metabolic Engineering, Elsevier Inc., 2020, 183-206.
7. X. Wei, P. Han, C. You*, Facilitation of cascade biocatalysis by artificial multi-enzyme complexes — A review, Chinese Journal of Chemical Engineering, 2020, 28 (11): 2799-2809.
8. X. Wei, L. Xie, Y.-H.P.J. Zhang, C. You*, Stoichiometric regeneration of ATP by a NAD(P)/CoA-free and phosphate-balanced in vitro synthetic enzymatic biosystem, ChemCatChem, 2018, 10 (24): 5597-5601.
The National Natural Science Foundation of China, The National Key Research and Development Program of China
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Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh@tib.cas.cn
