Microbial physiological and metabolic engineering to improve the robustness and efficient production of bio-based chemicals of industrial microbial cell factories.
2018.11-Present Associate professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2014.07-2018.11 Assistant professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2009.09-2014.07 Ph.D. Microbiology, College of Life Sciences, Nankai University, China;
2005.09-2009.07 B.S. Biotechnology, College of Life Sciences, Shandong Normal University, China
1. Papers
[1] Ju Y#, Zhang H#, Du X, Wei J, Liu J, Wei L*, Liu Q*, Xu N*. DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum. Metab Eng, 2023, 79: 182-191.
[2] Wang T, Zhang J, Wei L, Zhao D, Bi C, Liu Q, Xu N*, Liu J*. Developing a PAM-Flexible CRISPR-Mediated Dual-Deaminase Base Editor to Regulate Extracellular Electron Transport in Shewanella oneidensis. ACS Synth Biol, 2023, 12 (6): 1727-1738.
[3] Ding C#, Zhang J#, Qiao J, Ma Z, Liu P, Liu J, Liu Q*, Xu N*. Identification and engineering efflux transporters for improved L-homoserine production in Escherichia coli. J Appl Microbiol, 2023, 134 (4): lxad075.
[4] Wang J, Yang J, Shi G, Li W, Ju Y, Wei L, Liu J, Xu N*. Transcriptome profiles of high-lysine adaptation reveal insights into osmotic stress response in Corynebacterium glutamicum. Front Bioeng Biotechnol, 2022, 10: 933325.
[5] Liu G, Ding C, Ju Y, Ma Z, Wei L, Liu J, Liu Q*, Xu N*. Directed evolution of an EamB transporter for improved L-cysteine tolerance and production in Escherichia coli. FEMS Microbiol Lett, 2022, 368 (21-24): fnac008.
[6] Xu N#, Wang TL#, Li WJ#, Wang Y, Chen JJ*, Liu J*. Tuning Redox Potential of Anthraquinone-2-Sulfonate (AQS) by Chemical Modification to Facilitate Electron Transfer From Electrodes in Shewanella oneidensis. Front Bioeng Biotechnol, 2021, 9: 705414.
[7] Xu N#, Liu Y#, Jiang H*, Liu J*, Ma Y. Combining protein and metabolic engineering to construct efficient microbial cell factories. Curr Opin Biotechnol, 2020, 66: 27-35.
[8] Shi X, Yang M, Chu A, Zhang F, Feng J, Xu N*, Jiang Y, Li H*. Separation of α‐ketoglutaric acid by salting-out extraction coupled with solar-driven distillation. AIChE J, 2022, 68 (10): e17814.
[9] Guo J#, Ma Z#, Gao J, Zhao J, Wei L, Liu J, Xu N*. Recent advances of pH homeostasis mechanisms in Corynebacterium glutamicum. World J Microbiol Biotechnol, 2019, 35 (12): 192.
[10] Xu N#, Lv H#, Wei L, Liang Y, Ju J, Liu J*, Ma Y. Impaired oxidative stress and sulfur assimilation contribute to acid tolerance of Corynebacterium glutamicum. Appl Microbiol Biotechnol, 2019, 103 (4): 1877-1891.
2. Patents
[1] 刘君, 徐宁, 杜焕敏. 生产L-半胱氨酸的基因工程菌. 中国专利, 授权号: ZL 2022 1 0686536.8, 2023-09-05.
[2] 刘君, 魏亮, 徐宁. 一种生产L-高丝氨酸的基因工程菌及其应用. 中国专利, 授权号: ZL 202110061057.2, 2021-04-06.
[3] 刘君, 徐宁. 一种谷氨酸脱羧酶突变体及其在生产γ-氨基丁酸中的应用. 中国专利, 授权号: ZL 202011514707.6, 2021-03-02.
[4] 刘君, 魏亮, 徐宁. 高丝氨酸乙酰转移酶突变体及其在生产O-乙酰高丝氨酸中的应用. 中国专利, 授权号: ZL 202110139085.1, 2021-04-20.
[5] 刘君, 徐宁, 周威. 谷氨酸氧化酶突变体、双酶共表达载体及其应用. 中国专利, 授权号: ZL 201910787949.3, 2019-11-05.
Hosted or participated in more than 10 scientific research projects such as the National Key Research and Development Program of China, the National Natural Science Foundation, and Youth Innovation Promotion Association of the Chinese Academy of Sciences.
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