Engaged in extensive research involving the systematic design and construction of efficient biological conversion pathways guided by computational systems biology. My work focuses on various research directions, including the construction of metabolic network models, the development of model quality control methods, algorithms for designing non-natural pathways, and the prediction of targets for metabolic engineering. Notably, I have conducted significant research in the rational design of pathways guided by models, leading to the development of the comb-FBA pathway design algorithm. In recent years, I have shifted my focus to model quality control and the development of user-friendly online tools for pathway design, with a commitment to providing experimental biologists with accessible and reliable online tools.

1、Education Background

2006.09-2011.06, Harbin Medical University, Bioinformatics, Bachelor's Degree.

20011.09-2013.06, Tianjin University, Biochemical Engineering, Master's Degree

.2013.07-2017.06, Tianjin University, Biochemical Engineering, Ph.D.

2、Work Experience

2017.07-2020.04, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. Postdoctoral Researcher

2020.04 to Present, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences.，Biodesign Centre，Associate Researcher

In 2022, selected as a member of the Youth Promotion Association of the Chinese Academy of Sciences; in 2023, selected as a member of the "Scientific Master (Team)" of the Chinese Academy of Sciences as part of the Engineering Microbial Strain Casting Scientific Facility Team.

Published over 40 articles in domestic and international journals, with over 1070 citations and an h-index of 14. As the first or corresponding author, published 10 SCI research papers. Applied for 3 invention patents, granted 3 patents, and registered 3 software copyrights.

[1] Mao Zhitao^#, Yuan Qianqian ^#, Li Haoran ^#, Zhang Yue, Huang Yuanyuan, Yang Chunhe, Wang Ruoyu, Yang Yongfu, Wu Yalun, Yang Shihui, Liao Xiaoping*, Ma Hongwu*. CAVE: a cloud-based platform for analysis and visualization of metabolic pathways. Nucleic Acids Research, 2023, gkad360.

[2] Yuan Qianqian^#, Wei Fan ^#, Deng Xiaogui, Li Aonan, Shi Zhenkun, Mao Zhitao, Li Feiran*, Ma Hongwu*. Reconstruction and metabolic profiling of the genome-scale metabolic network model of Pseudomonas stutzeri A1501. Synthetic and Systems Biotechnology, 2023.

[3] Luo Jiahao; Yuan Qianqian^#; Mao Yufeng; Wei fan; Zhao Juntao; Yu Wentong; Kong Shutian; Guo Yanmei; Cai Jingyi; Liao Xiaoping; Wang Zhiwen*, Hongwu Ma*. Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems. Frontiers in bioengineering and biotechnology, 2022, 10: 913077-913077.

[4] Mao Yufeng^#; Yuan Qianqian^#; Yang Xue; Liu Pi; Cheng Ying; Luo Jiahao; Liu Huanhuan; Yao Yonghong; Sun Hongbing; Cai Tao; Ma Hongwu*; Non-natural Aldol Reactions Enable the Design and Construction of Novel One-Carbon Assimilation Pathways in vitro, Frontiers in Microbiology, 2021, 12(1360): 677596.

[5] Yuan, Xiao-Jie^#; Chen, Wen-Jing^#; Ma, Zeng-Xin^#; Yuan, Qian-Qian^#; Zhang, Min; He, Lian; Mo, Xu-Hua; Zhang, Chong; Zhang, Chang-Tai; Wang, Meng-Ying; Xing, Xin-Hui; Yang, Song*; Rewiring the native methanol assimilation metabolism by incorporating the heterologous ribulose monophosphate cycle into Methylorubrum extorquens, Metabolic Engineering, 2021, 64: 95-110.

[6] Cai, Tao; Sun, Hongbing; Qiao, Jing; Zhu, Leilei; Zhang, Fan; Zhang, Jie; Tang, Zijing; Wei, Xinlei; Yang, Jiangang; Yuan, Qianqian; Wang, Wangyin; Yang, Xue; Chu, Huanyu; Wang, Qian; You, Chun; Ma, Hongwu; Sun, Yuanxia; Li, Yin; Li, Can; Jiang, Huifeng; Wang, Qinhong; Ma, Yanhe*; Cell-free chemoenzymatic starch synthesis from carbon dioxide, Science, 2021, 373(6562): 1523.

[7] Wen, Mao^#; Yuan, Qian-Qian ^#; Hongge, Qi; Zhiwen, Wang; Hongwu, Ma; Tao, Chen*; Recent progress in metabolic engineering of microbial formate assimilation, Applied Microbiology and Biotechnology, 2020, 104(16): 6905-6917.

[8] Yang, Xue^#; Yuan, Qian-Qian ^#; Luo, Hao; Li, Feiran; Mao, Yufeng; Zhao, Xin; Du, Jiawei; Li,vPeishun; Ju, Xiaozhi; Zheng, Yangyang; Chen, Yang; Liu, Yuwan; Jiang, Huifeng; Yao, Yonghong; Ma, Hongwu*; Ma, Yanhe ; Systematic design and in vitro validation of novel one-carbon assimilation pathways, Metabolic Engineering, 2019, 56: 142-153.

[9] Yuan, Qian-Qian; Huang, Teng; Li, Peishun; Hao, Tong; Li, Feiran; Ma, Hongwu*; Wang, Zhiwen*; Zhao, Xueming; Chen, Tao*; Goryanin, Igor; Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models. PLos One, 2017, 12(1): e0169437. 

I have led two sub-projects of the National Key Research and Development Program by the Ministry of Science and Technology, one project funded by the National Natural Science Foundation of China for Young Scientists, and one project supported by the Talent Fund of Tianjin Municipality.