1. Development and application of genome editing and high-throughput screening technologies in actinomycetes.
2. Discovery and biosynthesis of value-added natural products in actinomycetes.
Website: https://orcid.org/0000-0002-4383-6313
Education
2011-2017: School of Chemical Engineering, Tianjin University, Ph.D. in Pharmaceutical Engineering
2007-2011: School of Chemistry, Nankai University, B.S. in Chemistry
Professional Experience
2021-present: Associate Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2017-2021: Assistant research fellow, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (No. 2023187)
1. Yue Zhang*, Xuemei Zhang, Meng Wang*. Product-driven high-throughput screening of industrial filamentous actinomycetes. Trends in Biotechnology, 2023, 41(9): 1109-1112.
2. Jin Wang, Ning Xue, Wenjia Pan, Ran Tu, Shixin Li, Yue Zhang, Yufeng Mao, Ye Liu, Haijiao Cheng, Yanmei Guo, Wei Yuan, Xiaomeng Ni, Meng Wang*. Repurposing conformational changes in ANL superfamily enzymes to rapidly generate biosensors for organic and amino acids. Nature Communications, 2023, 14(1): 6680.
3. Yan Wang, Shixin Li, Ning Xue, Lixian Wang, Xuemei Zhang, Longqian Zhao, Yanmei Guo, Yue Zhang*, Meng Wang*. Modulating sensitivity of an erythromycin biosensor for precise high-throughput screening of strains with different characteristics. ACS Synthetic Biology, 2023, 12(6): 1761-1771.
4. Xuemei Zhang, Yan Wang, Yue Zhang*, Meng Wang*. CRISPR/Cas9-Mediated Multi-Locus Promoter Engineering in ery Cluster to Improve Erythromycin Production in Saccharopolyspora erythraea. Microorganisms, 2023, 11: 623.
5. Erbing Hua#, Yue Zhang#*, Kaiyue Yun, Wenjia Pan, Ye Liu, Shixin Li, Yan Wang, Ran Tu*, Meng Wang*. Whole-cell biosensor and producer co-cultivation-based microfludic platform for screening Saccharopolyspora erythraea with hyper erythromycin production. ACS Synthetic Biology, 2022, 11(8): 2697-2708.（Cover story）
6. Kaiyue Yun#, Yue Zhang#, Shixin Li, Yan Wang, Ran Tu, Hao Liu*, Meng Wang*. Droplet-Microfluidic-Based Promoter Engineering and Expression Fine-Tuning for Improved Erythromycin Production in Saccharopolyspora erythraea NRRL 23338. Frontiers in Bioengineering and Biotechnology, 2022, 10: 864977.
7. Yue Zhang, Kaiyue Yun, Huamei Huang, Ran Tu, Erbing Hua, Meng Wang*. Antisense RNA interference-enhanced CRISPR/Cas9 base editing method for improving base editing efficiency in Streptomyces lividans 66. ACS Synthetic Biology, 2021, 10(5): 1053-1063.（Cover story）
8. Ran Tu#, Yue Zhang#, Erbing Hua, Likuan Bai, Huamei Huang, Kaiyue Yun, Meng Wang*. Droplet-based microfluidic platform for high-throughput screening of Streptomyces. Communications Biology, 2021, 4: 647.
9. Xiao Wen, Yue Zhang, Haijiao Cheng, Jingjing An, Yanmei Guo, Lixian Wang, Meng Wang. A CRISPR/dCas9-assisted system to clone toxic genes in Escherichia coli. Biochimica et Biophysica Acta (BBA) - General Subjects, 2021, 1865(11): 129994.
10. Chun-Yan Lin#, Yue Zhang#, Ji-Hua Wu, Rong-Hui Xie, Jianjun Qiao, Guang-Rong Zhao*. Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis. Microorganisms, 2020, 8(2): 271.
11. Chun-Yan Lin, Ai-Ping Pang, Yue Zhang, Jianjun Qiao, Guang-Rong Zhao*. Comparative Transcriptomic Analysis Reveals the Significant Pleiotropic Regulatory Effects of LmbU on Lincomycin Biosynthesis. Microbial Cell Factories, 2020, 19(1): 30.
Han Xiao#*, Yue Zhang#, Meng Wang*. Discovery and engineering of cytochrome P450s for terpenoid biosynthesis. Trends in Biotechnology, 2019, 37(6): 618-631.
1. National Natural Science Foundation of China (Youth fund).
2. National Key R&D Program of China (Sub-project).
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