Differential Scanning Calorimeter----Tianjin Institute of Industrial Biotechnology

Structural biology research platform Laboratory

Shared Equipment

Differential Scanning Calorimeter

Time：2024-12-19

Model: Nano DSC

Manufacturer: TA

Acquisition Date: 2011

Contact: Jie Zhang

Phone Number: 15022142553

Email: zhang_j@tib.cas.cn

Main configuration and technical specifications:

Cell volume: 300 µl;
Temperature range: -10°C to 130°C;
Sample cell material: Platinum;
Short-term noise level: 0.015 uW;
Baseline repeatability: 0.028 uW;
Scanning speed: 0.001 to 2℃/min.

Application and characteristics:

Nano DSC technology is specifically designed for measuring the thermal stability and heat capacity of proteins and other macromolecules in dilute solutions. It features a dual capillary design, which delays protein aggregation and precipitation until the unfolding process is complete, thus allowing the detection of pure structural changes during heating.This equipment is widely applied in the following areas:

Analyzing protein stability in dilute solutions, including data on molar heat capacity (ΔCp), phase transition temperature (Tm), and enthalpy changes;
Studying protein-ligand interactions, especially effective in characterizing tight or slow-binding interactions;
Characterizing advanced structures and homogeneity of biomacromolecules.

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