The Systems Biology Center is one of the core facilities of Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. We are oriented towards the research and service of systems biology for industrial life and processes. We have comprehensive capabilities in multi-omics instrument analysis, data analysis, and digital cell modeling, including genomics, transcriptomics, proteomics, metabolomics, environmental genomics, and molecular interactomics. Equipped with advanced gene sequencers, liquid chromatography-mass spectrometers, gas chromatography-mass spectrometers, nuclear magnetic resonance spectrometers, surface plasmon resonance instruments, and other large-scale analytical equipment, the total asset value of us exceeds 130 million RMB. We are devoted ourself to provide standardized/customized, quantitative, high-throughput systems biology analysis services, supporting the deepen understanding of life processes and promoting the development and application of industrial biological systems.
The Systems Biology Center provides services cover genomic, transcriptomic, proteomic, metabolomic, and molecular interaction analyses. We are equipped with advanced instruments, including (first, second and third generation) gene sequencers, liquid chromatography-mass spectrometry (e.g. Thermo Eclipse、Bruker timsTOF pro2、SCIEX EchoMS, etc), gas chromatography-mass spectrometry (Thermo Exploris GC240、Agilent 7010B, etc), nuclear magnetic resonance (NMR) systems (LC-SPE-NMR/MS), and biomolecular interaction analyzers (Cytiva SPR 8K、NanoTEMPER MST、MicroCal PEAQ-ITC, etc). Focusing on industrial biology, we provide various services for sample analysis and methodology developing, including genome and transcriptome sequencing, ChIP-seq, amplicon sequencing, insertion-site sequencing, qualitative and quantitative proteomics, protein post-translational modifications identification, biomolecular interaction analysis, target molecule ligand screening, affinity measurement, non-targeted and targeted metabolomics, high-throughput metabolomics, isotope labeling analysis, cation/anion, organic acid, and sugar analysis, metal element analysis, amino acid quantification, small molecule structure identification, and analysis of functional groups and molecular bond changes. We have established a "one-stop" testing and analysis technical system from sample preparation to acquisition of multi-omics data. Enables low-cost, high-throughput, multi-dimensional, and accurate cross-omics data acquisition and analysis evaluation, as well as diagnostic services. We aims providing comprehensive technical support for the understanding, development, and application of artificial cell factories.
Under the leadership of Professor, PhD Jibin Sun,the Systems Biology Center has a team of 18 staff members, including 7 individuals with senior titles (2 Professors), 24 graduate students. Our research interests include: Genomics and Transcriptomics (Yu Lei, Engineer ) Proteomics (Qichen Cai, Associated Professor, PhD) Metabolomics (Zhidan Zhang, Senior Engineer for liquid chromatography; Yonghong Yao, Senior Engineer for gas chromatography; Yi Cai, Senior Engineer for NMR) Biomolecular Interactions (Jie Shen/Senior Engineer, PhD) Data Integration and Analysis (Lifu Song/Associated Professor, PhD) Digital Cells (Yan Zhu/Professor, PhD) Group Web