The Intelligent Bio-Manufacturing Center is one of the six core platform laboratories at the Institute, dedicated to advancing intelligent manufacturing technologies for industrial bioprocesses. The laboratory focuses on critical aspects such as strain production capacity validation, fermentation process development and optimization, product separation and purification process development and optimization, and the pilot scale-up of biomanufacturing processes. By integrating big data and artificial intelligence technologies, the Center develops innovative methods, technologies, and equipment to significantly enhance the efficiency of existing biomanufacturing processes, which aims at shortening the time required to transition high-performance strains from the laboratory to industrial production. The Center boasts over 100 units of fermentation optimization and separation purification equipment and has established a comprehensive pilot platform for biomanufacturing. This platform integrates high-throughput strain performance verification, intelligent medium selection and optimization, efficient fermentation process development, and product separation and purification. It also includes eight pilot-scale digital fermentation lines, and a flexible, digital fermentation product separation and purification workshop. The Center’s interdisciplinary team comprises 22 experts, including 4 senior specialists and 18 professionals with master's degrees or higher, with expertise in fermentation engineering, biochemistry, separation engineering, automation, and artificial intelligence. Committed to modernizing traditional fermentation industries through automation and intelligence, the Center provides comprehensive support for the efficient industrialization of synthetic biology innovations.