Senior engineer Xu Han is mainly engaged in the research of structural biology, using structure biology technique to solve the three-dimensional structure and illustrate the structure and function relationship of Industrial important enzymes.

Study experience:

2003.09-2007.06, Bachelor in Biological Sciences, School of Life Sciences, Northeast Forestry University

2007.09-2010.06, Master in Microbiology, School of Life Sciences, Northeast Forestry University

Work experience:

2010.07-2014.04, Research Assistant, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2014.04-2020.07, Assistant Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2020.07-Now, Senior engineer, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Tianjin Natural Science Foundation, Second prize 6/8, 2019

(1) Chen, C.C.^#; Han, X.^#; Li, X.^#; Jiang, P.; Niu, D.; Ma, L.; Liu, W.; Li, S.; Qu, Y.; Hu, H.; Min, J.; Yang, Y.; Zhang, L.; Zeng, W.; Huang, J.-W.*; Dai, L*.; Guo, R.-T*. General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis. Nat Catal, 2021, 4(5):425-430.

(2) Chen, C.C.^#; Malwal S.R^#. ; Han, X.^#; Liu, W.; Ma, L.; Zhai, C.; Dai, L.; Huang, J.-W.; Shillo, A.; Desai, J.; Ma, X.; Zhang, Y.; Guo, R.-T; Oldfield, E. Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action. ACS Catal., 2020, 11(1):290-303.

(3) Han, X.^#; Liu, W.^#; Huang, J.-W.^#; Ma, J.; Zheng, Y.; Ko, T.-P.; Xu, L.; Cheng, Y.-S.; Chen, C.-C.; Guo, R.-T. Structural insight into catalytic mechanism of PET hydrolase. Nat. Commun. 2017, 8, 2106.

(4) Li, Z.^#; Zhao, Y.^#; Wu, P.^#; Wang, H.; Li, Q.; Gao, J.; Qin, H.; Wei, H.; Bornscheuer, U.T.; Han, X.*; Wei, R.*; Liu, W.*, Structural insight and engineering of a plastic degrading hydrolase Ple629.Biochemical and Biophysical Research Communications, 2022,626,100-106

(5) GHaugwitz, G; Han, X.; Pfaff, L.; Li Q.; Wei, H.; Gao, J.; Methling K.; Ao Y.; Brack Y. ; Mican J.; Feiler G. C.; Weiss M. S.; Bednar D.; Palm G. J.; Michael Lalk; Lammers M.; Damborsky J.; Weber G.; Liu, W.*; Bornscheuer,U.T.*; Wei, R.*, Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization. ACS Catal. 2022, 12 (24), 15259-15270.

1. Sub project of National Key Research and Development, Heterologous efficient expression and formulation of PET depolymerase, 2023.12-2027.11

2. Sub project of National Key Research and Development, Key technologies for efficient biopolymerization of plastics, 2021.12-2024.12

3. National Natural Science Foundation of China, Youth Science Foundation Project, Study on the molecular mechanism of novel PET hydrolase, 2019.01-2021.12