Understanding the molecular foundation and regulatory mechanisms underlying the synthesis of metabolites in industrial microorganisms. Employing techniques such as metabolic engineering, synthetic biology, and biosensor technology to establish efficient microbial cell factories for the production of amino acids, organic acids, and high-value-added chemicals

2008.09-2012.07, Shandong Agricultural University, Bioengineering, Bachelor;

2012.09-2015.07, Tianjin University, Biochemical Engineering, Master;

2015.09-2019.07, Institute of Industrial Biotechnology, Chinese Academy of Sciences, Microbiology, Ph.D.;

2019.07-2022.07, Postdoctoral research at the Institute of Industrial Biotechnology, Chinese Academy of Sciences;

2022.09-present, Associate Researcher at the Institute of Industrial Biotechnology, Chinese Academy of Sciences.

[1] Yun Ju, Hongyu Zhang, Xiaocong Du, Jingxuan Wei, Jun Liu, Liang Wei*, Qingdai Liu*, Ning Xu*. DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum[J]. Metabolic Engineering, 2023, 79: 182-191.

[2] Huanmin Du, Yuting Qi, Jinfang Qiao, Lingcong Li, Ning Xu, Li Shao, Liang Wei*, and Jun Liu*. Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum[J]. Journal of Agricultural and Food Chemistry, 2023, 71(37): 13848-13856. 

[3] Huanmin Du, Jinfang Qiao, Yuting Qi, Lingcong Li, Ning Xu, Li Shao, Liang Wei*and Jun Liu*. Reprogramming the sulfur recycling network to improve l-cysteine production in Corynebacterium glutamicum[J]. Green Chemistry, 2023, 25(8): 3152-3165.

[4] Jinshan Gao, Muhua Du, Jinhua Zhao, Yue zhang, Ning Xu, Huanmin Du, Jiansong Ju, Liang Wei*, Jun Liu*. Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction[J]. Metabolic Engineering, 2022, 73: 144-157.

[5] Liang Wei, Jinhua Zhao, Yiran wang, Jinshan Gao, Muhua Du, Yue zhang, Ning Xu, Huanmin Du, Jiansong Ju, Qingdai Liu*, Jun Liu*. Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control[J]. Metabolic Engineering, 2022, 69: 134-146.

[6] Liang Wei, Qian Wang, Ning Xu, Jian Cheng, Wei Zhou, Guoqiang Han, Huifeng Jiang*, Jun Liu*, and Yanhe Ma.Combining protein and metabolic engineering strategies for high-level production of O-acetylhomoserine in Escherichia coli[J]. ACS Synthetic Biology, 2019, 8(5): 1153-1167.

[7] Liang Wei, Hao Wang, Ning Xu, Wei Zhou, Jiansong Ju*, Jun Liu*, Yanhe Ma. Metabolic engineering of Corynebacterium glutamicum for L-cysteine production[J]. Applied microbiology and biotechnology, 2019, 103: 1325-1338.

[8] Liang Wei, Ning Xu, Yiran Wang, Wei Zhou, Guoqiang Han, Yanhe Ma & Jun Liu*. Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum[J]. Applied microbiology and biotechnology, 2018, 102: 4117-4130.

[9] Liang Wei, Jiao Liu, Haishan Qi, Jianping Wen. Engineering Scheffersomyces stipitis for fumaric acid production from xylose[J]. Bioresource technology, 2015, 187: 246-254.

National Natural Science Foundation of China (NSFC), Tianjin Natural Science Foundation, China Postdoctoral Fund Project, and the Tianjin Synthetic Biology Innovation Capability Enhancement Action Project.