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CAS Key Laboratory of Systems Microbial Biotechnology


The Laboratory focuses on applied basic research in the field of microbial biotechnology. Targeting at the national need on energy, environment and sustainability, we combine genomics, systems biology and synthetic biology to elucidate the molecular basis of microbial physiology and metabolic regulation, develop new methods and tools for biological networks modeling, biological design, metabolic pathway engineering, genomic engineering, evolutionary engineering, physiological engineering, rebuild the technology chain from genome to products, create highly efficient microbial cell factories and optimal processes for production of bio-based materials, biofuels, fine and bulk chemicals.

Main research area

1.   Genomics and functional genomics of industrial microorganisms and bioprocesses

2.   Simulation and design of biological networks

3.   Discovery, improvement and creation of functional biological parts

4.   Construction and optimization of efficient cell factory

5.   Design and optimization of in vitro biosystems


Principal Investigator

Research area

Zugen Chen

Genome analysis

Chaoguan Tian

Microbial functional genomics and genetics of filamental fungi

Wenqing Shui

Biological mass spectrum

Dawei Zhang

Proteomics and Bacillus engineering

Jibin Sun

Systems biology of industrial microbes

Hongwu Ma

Reconstruction and design of biological network

Tao Liu

Natural products

Huifeng Jiang

Evolutionary genetics and enzyme design

Jingdong Tian

Artificial synthesis of DNA

Weimin Gong

Chemical biology

Jiangyun Wang

Chemical biology

Xueli Zhang

Microbial metabolic engineering

Qinhong Wang

Microbial evolution engineering

Jiangning Song

Systems biology and protein design

Ruiging Guo

Protein crystallography and structure biology

Wenxia Jiang

Fermentation engineering

Academic Committee




Shengli Yang, chairman


CAS member

Shanghai Institutes for Biological Sciences, CAS

Pingkai Ouyang


CAS member

Nanjing University of Technology

Zixin Deng


CAS member

Shanghai Jiao Tong University

Guoping Zhao


CAS member

Shanghai Institutes for Biological Sciences, CAS

Zhu’an Cao


Tsinghua University

Yanhe Ma


Tianjin Institute of Industrial Biotechnology, CAS

Jian Chen


Jiangnan University

Yingjin Yuan


Tianjin University

Siliang Zhang


East China University of Science and Technology

Jianjiang Zhong


Shanghai Jiao Tong University

Huimin Zhao


University of Illinois at Urbana-Champaign

Guoqiang Chen


Tsinghua University

Weihong Jiang


Shanghai Institutes for Biological Sciences, CAS

Guowang Xu


Dalian Institute of Chemical Physics, CAS

Haiyan Liu


University of Science and Technology of China

Wen Liu


Shanghai Institute of Organic Chemistry, CAS

Yin Li


Institute of Microbiology, CAS

Director of the Academic Committee:  Shengli Yang, PhD, Professor, CAS Member

Deputy Director of the Lab: Xueli Zhang, PhD, Professor

Secretary: Ms Ru Liu

Contact: Tel/Fax +86-(0)22-84861969


32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China
Tel: 022-84861997/84861977 Fax: 022-84861926 E-mail: tib_zh(AT)
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